<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14593

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceMSEEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGDARQVEEYVFAKCMSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSQFHSPPCTTAVLGGTTPVGSTPGYRAPVPPDPQPTSAQARNPPSTVATTQASTTPSSQSTAPAGTVSASAAVAAAVANFPSPDTALRVGGQTTPGSQSSGQSSAPNVPFPNGGPQQGSVPMNGGGGPAMGQPPPQMGAPNMGMGGPPGGYGGYGMMNGPPGGGPMGGNPYNQQMKKEMEQNRPWDPQGHMYQQPQWGGMPPQQGHGYANRPMNGQQTTPTGTSSVLESLINQPQQYPGHHNQMGPPGPDRNMPGNRPGAGPGGPQRPGMPVNQAMMSVEDQNVYSMKLRNMRGSCESLRTRARQCRQEGNHEAAHKLEVMLSVLEGKRVVSLEYLNHLETWIARKQDFLNINQMAQNPNHMGMNDPVMNGDHGMMGNGQVHNPYGGHPGYNHGQYMGGPPPHMQQQMHPSQMWHQQQQQQRMMSSQEHMMMSGGGPMHGMYRGDMGHDQMTSPVNNHRHAPYQNPAMRNNMRQMPNGPGQIGRDRNSMSGSMSGPSSGAPSMNPMGTPNQKMGTPGSIGGLSGLDDFTYDDFLPNPIDALQPTLHVGNPSNSMNSGQPVQRASLTETARKELQALEARFEIDPNHQRHDANHILVSCKLRNQPYPPLRLVVPTTYPAGNVTVDRAVIDLDAYLYDDLQNVVNERLSRPGLSSLTDYLNAWEEQVNQYLQQNQSDMGPSFGVSNDFFYENLNLSNAF
Length779
PositionTail
OrganismCaenorhabditis latens
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.06
Grand average of hydropathy-0.819
Instability index57.97
Isoelectric point6.60
Molecular weight84311.21
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14593
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     304.98|      34|      34|     177|     210|       1
---------------------------------------------------------------------------
   82-  112 (40.45/ 8.82)	P.SQ.F..HSPPCTT.A..V.LGGT...........TPVG....STP...GYR..A.PVP
  113-  145 (33.70/ 6.08)	PDPQpTSAQARNP...P..S.TVAT...........TQAS....TTP...SSQ..S.TAP
  177-  210 (67.61/19.85)	PGSQ.SSGQSSAPNV.P..F.PNGG...........PQQG....SVP...MNG..G.GGP
  211-  247 (51.92/13.48)	AMGQ.PPPQMGAPNM.G..M...GG...........PPGG....YGGygmMNGppG.GGP
  252-  301 (36.87/ 7.37)	PYNQ.QMKKEMEQNR.P..WdPQGHmyqqpqwggmpPQQGhgyaNRP...MNG..Q.QTT
  302-  331 (38.71/ 8.12)	PTGT.SSVLESLINQ.PqqY.PGHH...........NQMG....P.P...........GP
  544-  578 (35.72/ 6.90)	PY.Q.NPAMRN..NMrQ..M.PNGP...........GQIGrdrnS.....MSG..SmSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     224.37|      47|      69|     424|     470|       2
---------------------------------------------------------------------------
  351-  394 (61.44/17.60)	GMPVNQAMMSVED..QNVYSMKLR..N..MRGScESLRTRARQCRQEGNH
  424-  470 (88.82/28.16)	WIARKQDFLNINQMAQNPNHMGMN..DPVMNGD.HGMMGNGQVHNPYGGH
  496-  540 (74.11/22.49)	WHQQQQQ....QRMMSSQEHMMMSggGPMHGMY.RGDMGHDQMTSPVNNH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.14|      36|     132|     592|     631|       3
---------------------------------------------------------------------------
  592-  631 (62.11/45.51)	NQKMGTPgsigGLSGLDDF......TYDDFLPNPIDALQPTLHVGN
  725-  766 (56.02/31.74)	NERLSRP....GLSSLTDYlnaweeQVNQYLQQNQSDMGPSFGVSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.02|      14|     132|     336|     350|       7
---------------------------------------------------------------------------
  336-  350 (26.98/11.60)	PGNRPGAGPGGPQrP
  471-  484 (33.04/11.48)	PGYNHGQYMGGPP.P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14593 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DALQPTLHVGNPSNSMNSGQPVQRASLTETARKELQALEARFEIDP
2) MSEEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGDA
3) PSVLQPSQFHSPPCTTAVLGGTTPVGSTPGYRAPVPPDPQPTSAQARNPPSTVATTQASTTPSSQSTAPAGTVSASAAVAAAVANFPSPDTALRVGGQTTPGSQSSGQSSAPNVPFPNGGPQQGSVPMNGGGGPAMGQPPPQMGAPNMGMGGPPGGYGGYGMMNGPPGGGPMGGNPYNQQMKKEMEQNRPWDPQGHMYQQPQWGGMPPQQGHGYANRPMNGQQTTPTGTSSVLESLINQPQQYPGHHNQMGPPGPDRNMPGNRPGAGPGGPQRPGMPVNQAMMSVEDQNVYSMKLRNMRGSCESLRTRARQCRQEGNHEAAHKLEVMLS
4) QDFLNINQMAQNPNHMGMNDPVMNGDHGMMGNGQVHNPYGGHPGYNHGQYMGGPPPHMQQQMHPSQMWHQQQQQQRMMSSQEHMMMSGGGPMHGMYRGDMGHDQMTSPVNNHRHAPYQNPAMRNNMRQMPNGPGQIGRDRNSMSGSMSGPSSGAPSMNPMGTPNQKMGTPGSIGGL
621
1
77
429
666
39
405
604










Molecular Recognition Features






MoRF SequenceStartStop




1) KFREHVI
10
16