<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14570

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQESVEFSTLVNRAAEESYLSLKELVEKSRSSEMSDSEKKISILKYLVKTQQRMLRLNVLAQWCQQVPLIQYCQQLASTLSSHETCFTQAADSMFFMHEGLQQARAPIYDVPSAIEILLTGTYERLPKCTEDVGIQSTLTEKQQKPVLKKLDTIVRSKLLETTLPKEFSEVKIFDGTVTLCVPGEFKVLLTLGYRGHLSMWRILHLEVLVGEKSGPVKLEETRRFVLGDDLERRMAASENPFAILYSILHEFCVALVMDTVIRQVRELRVGRWKDAIRFELISDGNSGQSQSNAIGSMQMGQDVETDSGGLRTPGLKIIYWLDFDKSTGTSDSVSCPFIKIEPGPDLQIKCIHSSFVIDPVTNREAEFSIDQSCIDVEKLLLRAICCNKYTRLLEIYKELGQNSHSCRAGGDVILHSPVDQTGADYNKDDILDSEGQEVLRMRAYGSSFFTLGINIRTGRFLLHSSKSTIASSALRECEEALNQGSMTAAEAFISLRSKSLLHLFACVGRFLGLQVYEHSFSPVKVPKHVLNGSNMLLMGFPDCGSSYFLLMQLEDDFRPIFKLLETQPDPSGKAESSVTRIKIVDINQMHLLEGELNSSLLDYNTLTVTSSENDSVPSQASDHGLLSDLTVQGSGLSGFSSLVDEIFEQERRSSASAGAGSNWNGSLYPANNSYRGRVPSASTSSITSRSTTMKKMSASKSDQDLASRSQHSAEVGSYITGGARVSASSARGNTFRNSVSTPDSPMTQVSRENGSRKRTLLDMLDFLPSLKSSDIVAQSSKRRNFSNTTATQNQLSNVSNIEKYRYVNLIAEANKGDAPSSIYVSALLLVVRHCSLCIKHARLTSQMDALDIPYAEEIGLRTASSNIWFKLPFARNDTWEHICLRLGKKLGSMYWDVKISDQHFIDLFELQKGSSDTAWGSNVRIANASDIDSHIRYDADGVVLTYNSVEADSIKKLVADIQRLSNARTFALGMRKLLVVKSDEKTEESRSKGSLEVGDKYIEQMRKAFKIEAVGLMSLWFSFGSGVSGVLARFVVEWESGKNGCTMHVSPDQLWPHTKFLEDFINGTEVSSLLDCIRLTAGPLHALAAATRPARAAPVSGAASAVPTLSRANVNGQMPNGTNPNVGHGSGPGTGPGGNPGASAMLTAATVASRGGPGIVPSSLLPIDVSFVLRGPYWIRIIYRKYFAVDMRCFAGDQVWLQPATPPKGGPTVGGSLPCPQFRPFIMEHVAQELNGLDPNFAGGQPSAGPTNSNNSAASPGPQLSATNGTRAGPTVMSRPGNQPVGFNRSTNAMSASPNSLLVRRATGTVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFNPSQQQQQNNSVIGQDELTQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKSLAQAQGSDIPPAQRSRIELCLENHSGLYTDGNSENSSASKSNIHYDRPHNAVDFGLTVVLDPAHIPHINAAGGAAWLPYCVSVRLKYSFGENPNVGFLGMEGSHGGRSCWLRVEDWELCKQRVIRTVDMNASSGGDVNQGRLRMVADNVQRTLHNSLQSLRTGGGGNTT
Length1662
PositionTail
OrganismHelianthus annuus (Common sunflower)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Heliantheae alliance> Heliantheae> Helianthus.
Aromaticity0.07
Grand average of hydropathy-0.206
Instability index44.72
Isoelectric point7.05
Molecular weight181700.18
Publications
PubMed=28538728

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14570
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.57|      13|      14|    1116|    1129|       1
---------------------------------------------------------------------------
 1112- 1128 (16.38/10.35)	PtlsRANVNGQMPNGtN
 1129- 1144 (22.18/10.11)	PnvgHGSGPGTGPGG.N
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.59|      16|     175|    1160|    1180|       3
---------------------------------------------------------------------------
 1160- 1180 (20.44/29.47)	GGpGIVPSsllpIDVSFVLRG
 1337- 1352 (31.15/20.69)	GG.GWVPL....VALKKVLRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     372.96|     113|     565|     887|    1044|       4
---------------------------------------------------------------------------
  568-  640 (62.78/24.06)	..........................LLE.....TQPDPSGKAESSVTRI.KIVDIN....QmHlLEG..ELNSSLLDYNtltvtSSENDSVPSQASDHGLLSDLTVQGSG..................................................................
  887- 1044 (156.60/194.06)	ICLRLGKKLGSMYWDV.KISDqhFIDLFE.....LQKGSSDTAWGSNVRIANASDID....S.H.IRY..DADGVVLTYN.....SVEADSIKKLVADIQRLSNARTFALGmrkllvvksdekteesrskgslevgdkyieqmrkafkieaVGLMSLWFSFGsGVSGVLaRfVVEWE
 1449- 1610 (153.58/104.70)	ICDYFSRRVASEPYDAsRVAS..FITLLTlpisvLREFLKLIAWKKSLAQAQGSDIPpaqrS.R.IELclENHSGLYTDG.....NSENSSASKSNIHYDRPHNAVDFGL...tvvldpahiphinaaggaawlpycvsvrlkysfgenpnVGFLGMEGSHG.GRSCWL.R.VEDWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.63|      23|      47|     732|     755|       5
---------------------------------------------------------------------------
  732-  755 (34.59/28.53)	ASSARGNTFRNSVSTPDSpMTQVS
  782-  804 (38.03/25.35)	AQSSKRRNFSNTTATQNQ.LSNVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.01|      14|      55|     657|     670|       7
---------------------------------------------------------------------------
  657-  670 (26.88/20.05)	RSSASAGAGSNWNG
  713-  726 (26.14/19.24)	RSQHSAEVGSYITG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.66|      19|      23|    1244|    1265|       8
---------------------------------------------------------------------------
 1244- 1265 (32.12/26.05)	PnfaGGQPSAGPTNSNNSAASP
 1285- 1303 (35.54/20.29)	P...GNQPVGFNRSTNAMSASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     279.20|      67|      71|     184|     250|       9
---------------------------------------------------------------------------
  115-  179 (82.51/48.63)	..VPSAIEILLTGTYERLPKCTE.DVGIQSTLTEKQQkPV.LKKLDTIVRSKLLETTLPKEFSE.VKIFD
  184-  250 (105.66/64.40)	LCVPGEFKVLLTLGYRGHLSMWR.ILHLEVLVGEKSG.PVKLEETRRFVLGDDLERRMAASENP.FAILY
  256-  324 (91.02/54.42)	FCVALVMDTVIRQVRELRVGRWKdAIRFELISDGNSG.QSQSNAIGSMQMGQDVETDSGGLRTPgLKIIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.56|      25|      48|     463|     490|      10
---------------------------------------------------------------------------
  463-  490 (34.17/32.60)	GRFL.LHSSKSTIasSALRECEEALNqGS
  513-  538 (41.40/26.75)	GRFLgLQVYEHSF..SPVKVPKHVLN.GS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.84|      15|     166|    1047|    1061|      11
---------------------------------------------------------------------------
 1047- 1061 (33.57/19.64)	KNGCTMHVS.P.DQLWP
 1213- 1229 (21.27/ 9.67)	KGGPTVGGSlPcPQFRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14570 with Med14 domain of Kingdom Viridiplantae
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