<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14566

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMEKSFSKLTSRPILCFRCRINLLTIYSTLVDRLKDVERDCMASGQEIDDSSNKNSSPKKVYKDPDDGRQRFLLELEFVQCLANPTYIHYLAQNRYFEDEAFIGYLKYLQYWQRPEYIKYIMYPHCLYFLELLQNASFRNAMAHPANKELTHRQQFYFWKNYRNNRLKHILPRPLPEPTAAPPSNALPPPLPPSATTMATSSAPVSAPPVPSPMQYGVPSGPPLVKNDPRNAIDRRKRKKDG
Length241
PositionMiddle
OrganismHelianthus annuus (Common sunflower)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Heliantheae alliance> Heliantheae> Helianthus.
Aromaticity0.11
Grand average of hydropathy-0.665
Instability index58.29
Isoelectric point9.41
Molecular weight27972.81
Publications
PubMed=28538728

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364129
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP14566
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.11|      18|      18|     187|     204|       1
---------------------------------------------------------------------------
  171-  185 (27.38/12.06)	PRPLPEPT...AAPPSNA
  187-  204 (33.84/16.52)	PPPLPPSATTMATSSAPV
  206-  221 (26.89/11.71)	APPV.PSPMQYGVPSGP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.97|      20|      27|      71|      90|       2
---------------------------------------------------------------------------
   71-   90 (37.17/25.37)	FLLELEFVQCLANPTYIHYL
  101-  120 (39.81/27.66)	FIGYLKYLQYWQRPEYIKYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.15|      13|      27|     126|     138|       4
---------------------------------------------------------------------------
  126-  138 (21.61/12.51)	LYFLELLQNASFR
  155-  167 (25.54/15.87)	FYFWKNYRNNRLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14566 with Med31 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPTAAPPSNALPPPLPPSATTMATSSAPVSAPPVPSPMQYGVPSGPPLVKNDPRNAIDRRKRKKDG
176
241










Molecular Recognition Features






MoRF SequenceStartStop




1) PLVKNDPRNAIDRRK
222
236