<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14516

Description Putative mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHATNCTSAVNNSAVGGSLGRDTSRAESSALPANFQSNRRPSQLAPYKLRCEKDPLNSRLPPPDFHPPTTNCPEETLTKDYVLAGYRETVEGLEESREISLSQISTFTKPVILKCKEAIRKYHRAINESRAQKRKAGQVYGVPLTGNLLSKPGVFPEQKASGEDFRKKWIEGLSQQHKRLRSLADHVPHGYRKKALFEVLIRNNVPLLRATWFIKVTYLNQVRPGSSSTSSGSPDRTRFSRSEQWTKDVIEYLQHLLDEFVQKSNSHSTLHIKDRSPQFAYGGSIQHKNDLVSAVDSDEPSLHFKWWYVVRIIQWHYAEGLLLPSLIIDWVLNQLQEKELLVILQLLLPIIYVVIESMVLSQNYVHILVGIAVRFIQEPSPGGSDLVDNSRRAYTITALVEILRYLLLAVPDTFVAQNCFPLPSCVVLNAPNDGSLITRVTGEQQLSINSVVYSIRKRATNLSKVAKPDYSGHNVAKVVHELDKALIHGDITIAYKCMFEDFCDETFDKRWIADVSTCLRSSLKWIGTVGSSFMCSVFFICEWATCDFRDFRVGPPRGIKFSGKRDFSQVYVATRLLEMKTRNMRSSSRPKAGVRKVKDLSQFFQSPGPLHDIIVCWIDQHQAQSGEGFKRVQLLINELIRSGIFYPQAYVRELIVSGIMGMVDFDRKRRHFKLLKHLPGLYIQDALQEAQIAETSLITEAMHIYSNERRLLLHELVDHPKNNIVSNKPKNHQKFVKDQWPVPSPSNANRKIEEVMNSIAVLLHFSNSQSTIGNGSEESRDVKRTTGPMVISEMTPGCEECRRAKRQKVEEKSPYPYLSDDEDIWWLKKGQTLKSMESFRAIEPPVKPVKQATRGRQKTVRKTSSLAQLAAARIEGSQGASTSHVCDSRVNCPHHRNGISNNDSDVPKTTDSVTTVHLGDASSIGNVLKRVPLDEKRVVVVWLMGTVRQLVDEAGKITETAPKVGHFGRNSSPVDDKGSAKWKLGEDELSTILYLMDVCDDLVSAARFLVWLLPKIPINPIPTVHGGRNVMIVPRNVENQLCSVGETFVLSSLRRYENILAAANLIPETLSSMMNRASVVMASNGRVSGSAALVFARQMLKKYGHVATVGDWIKNFKTTADKRLVMELESGRSSDGEFGLPLGVPAGVQDFDEFLLKKISGVRISRVGLSMRDIVQRLVDEAISAFYGQEKKSFTGGPMKKPTVQKPDDGYLTAQQVVKGLMDCMRQTGGAAQEGDPTLVAFAVSAIVSNVGQVIAKITEITPVSLTFSRHIIRVHLTCLSLLKDALGERQSRVFEIALATEASSALSQVFSPPKASRGQLQLSPETRDPMSNENPTFSKAAKTTGAISALVIEAVLQGITSLERMVTVLRLKDGINVIQFLKSTRSNSNGNVRSIGDLKAENLVEVSVHWFRVLVGNCRTVSDGFIVDLLGESSIVALSRIQRVLPINLVFPPAFAIFGFLVWKRFIFNANIMARDNISQLFHSLRSAISDAIKHLPFRDVCLRECATLYDLVAADTSDSEFAEMLDLSGPDMHSKISAFVPLRARIFLNSIIDCQLPNEIISHDDGNRADLNEMKLLDRLVHILDTLQPAKFHWQWVELRLLLNEQALIGKVEARDTSLAEALRSFSPNNENVSDNENNFIQMVLTRLLVRPDAAPLFSEVVHLLGRSLEDEVLQQAKWFLRGHDVLFGRKSIRQRLINIAESKSLSTKIQFSKPWGWCNNNLSPMPGPVKKGNKRKFESVSLEEGEVVDDGNGTGPDTKRHSSRTFGPVSDVEAFIVSQQHVTEKALVELLLPCIDQSSNDSRFTFASDLIKQMNDIEQQISNVTHGVNKLLPVVSGGIEGPVTKVNTRKGLRGSSPGLARRLAGPVEMMLPSPSALRASISLRLQLLLRLLPVICADGEPSFRSLRHMLASVVLRLLGSRVVHEDADLYNPTSASVDLGESLYDRLLLVLHALLSTSQPYWLRPKSSSKATSEGSRDSNPYDREVAEKLQNELDGMQLPDAVRWQIQTVMPFVFHTARFSISCQPPNVPLSALGLLQPSVSIPIPHPGNHRNSQGPSSRAMSNGPGKASNSKPVSSQPDSDIEIDPWTLLEDGAGSGPSSINAAAIAGTDHANLKASSWLKGAVRVRRMDLTYIGAIDDDS
Length2148
PositionKinase
OrganismHelianthus annuus (Common sunflower)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Heliantheae alliance> Heliantheae> Helianthus.
Aromaticity0.07
Grand average of hydropathy-0.229
Instability index46.52
Isoelectric point9.01
Molecular weight238773.74
Publications
PubMed=28538728

Function

Annotated function
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions

Repeat regions

Repeats

>MDP14516
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.59|      13|      29|     505|     521|       1
---------------------------------------------------------------------------
  505-  521 (22.48/23.51)	F.CDETFDKRWiadvSTC
  536-  549 (23.10/13.11)	FmCSVFFICEW....ATC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     369.80|     121|    1179|     558|     684|       2
---------------------------------------------------------------------------
  559-  684 (198.31/147.15)	PRGIKFSGKRDFSQVYVAT.RLLE....MKTRNMRSSSRPKAGVRKVKD..LSQFFQSPGPLHDIIV.CwIDQHQAQSgeGFKRVQLLINEL..IRSGIFYPQAYVREL..IVS.GIMGMVDFDRKRRHFKllKHLPGL
 1732- 1865 (171.49/106.84)	PGPVKKGNKRKFESVSLEEgEVVDdgngTGPDTKRHSSRTFGPVSDVEAfiVSQQHVTEKALVELLLpC.IDQSSNDS..RFTFASDLIKQMndIEQQISNVTHGVNKLlpVVSgGIEGPVTKVNTRKGLR..GSSPGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     249.06|      52|     129|    1158|    1209|       3
---------------------------------------------------------------------------
 1102- 1153 (61.58/41.85)	MLKKYG..H.....VATV.GDWIKNFKttadKRLVMELES...GRSSDG........EFGLPL..GVPAgVQD
 1158- 1209 (84.17/60.51)	LLKKISGVR.....ISRV.GLSMRDIV....QRLVDEAISAFYGQEKKS........FTGGPM..KKPT.VQK
 1214- 1262 (49.15/31.58)	YLTAQQVVKglmdcMRQT.GGAAQEGD....PTLVAFAVSAIV.....S........NVGQVI..AKIT....
 1285- 1343 (54.17/35.73)	LLKDALGER.....QSRVfEIAL........ATEASSALSQVFSPPKASrgqlqlspETRDPMsnENPT.FSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.47|      46|     516|     227|     273|       4
---------------------------------------------------------------------------
  227-  273 (74.69/63.25)	PGSSSTSSGSPDRTRFSRsEQW.......TKDVIEYLQHLLDEFVQKSNSHSTL
  723-  775 (71.77/55.17)	PKNNIVSNKPKNHQKFVK.DQWpvpspsnANRKIEEVMNSIAVLLHFSNSQSTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.47|      94|     341|    1547|    1662|       9
---------------------------------------------------------------------------
 1497- 1606 (142.42/114.26)	IKHLPFRDVCLRECATLYDLVAADTSDSE..FAEML...DLSGPDMHskisafvpLRARIFLNSIIDcQLPNEIISHDD..GNRAdlnemkLLDRLVHILDT......LQPAKfHWQWVELRL
 1614- 1728 (134.05/91.65)	IGKVEARDTSLAEALRSFSPNNENVSDNEnnFIQMVltrLLVRPDAAplfsevvhLLGRSLEDEVLQ.QAKWFLRGHDVlfGRKS......IRQRLINIAESkslstkIQFSK.PWGWCNNNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.44|      70|    1179|     880|     951|      10
---------------------------------------------------------------------------
  880-  951 (118.00/75.97)	SQGASTSHVCDSRVNCPHHRNGISNNDSDVPktTDSVTTVHLGDAS..SIGNVLKRVPLDEKRV.VVVWLMGTVR
 2060- 2132 (111.44/66.22)	SQGPSSRAMSNGPGKASNSKPVSSQPDSDIE..IDPWTLLEDGAGSgpSSINAAAIAGTDHANLkASSWLKGAVR
---------------------------------------------------------------------------




Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP14516 with Med12 domain of Kingdom Viridiplantae

Intrinsically Disordered Regions

IDR SequenceStartStop
1) AVNNSAVGGSLGRDTSRAESSALPANFQSNR
2) ESFRAIEPPVKPVKQATRGRQKTVRKTSSLAQLAAARI
3) IGNGSEESRDVKRTTGPMVISEMTPGCEECRRAKR
4) SIPIPHPGNHRNSQGPSSRAMSNGPGKASNSKPVSSQPDSDIEIDPWTL
5) TSHVCDSRVNCPHHRNGISNNDSDVPKTTDSVTT
12
840
775
2048
885
42
877
809
2096
918

Molecular Recognition Features

MoRF SequenceStartStop
NANANA