<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14516

Description Putative mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHATNCTSAVNNSAVGGSLGRDTSRAESSALPANFQSNRRPSQLAPYKLRCEKDPLNSRLPPPDFHPPTTNCPEETLTKDYVLAGYRETVEGLEESREISLSQISTFTKPVILKCKEAIRKYHRAINESRAQKRKAGQVYGVPLTGNLLSKPGVFPEQKASGEDFRKKWIEGLSQQHKRLRSLADHVPHGYRKKALFEVLIRNNVPLLRATWFIKVTYLNQVRPGSSSTSSGSPDRTRFSRSEQWTKDVIEYLQHLLDEFVQKSNSHSTLHIKDRSPQFAYGGSIQHKNDLVSAVDSDEPSLHFKWWYVVRIIQWHYAEGLLLPSLIIDWVLNQLQEKELLVILQLLLPIIYVVIESMVLSQNYVHILVGIAVRFIQEPSPGGSDLVDNSRRAYTITALVEILRYLLLAVPDTFVAQNCFPLPSCVVLNAPNDGSLITRVTGEQQLSINSVVYSIRKRATNLSKVAKPDYSGHNVAKVVHELDKALIHGDITIAYKCMFEDFCDETFDKRWIADVSTCLRSSLKWIGTVGSSFMCSVFFICEWATCDFRDFRVGPPRGIKFSGKRDFSQVYVATRLLEMKTRNMRSSSRPKAGVRKVKDLSQFFQSPGPLHDIIVCWIDQHQAQSGEGFKRVQLLINELIRSGIFYPQAYVRELIVSGIMGMVDFDRKRRHFKLLKHLPGLYIQDALQEAQIAETSLITEAMHIYSNERRLLLHELVDHPKNNIVSNKPKNHQKFVKDQWPVPSPSNANRKIEEVMNSIAVLLHFSNSQSTIGNGSEESRDVKRTTGPMVISEMTPGCEECRRAKRQKVEEKSPYPYLSDDEDIWWLKKGQTLKSMESFRAIEPPVKPVKQATRGRQKTVRKTSSLAQLAAARIEGSQGASTSHVCDSRVNCPHHRNGISNNDSDVPKTTDSVTTVHLGDASSIGNVLKRVPLDEKRVVVVWLMGTVRQLVDEAGKITETAPKVGHFGRNSSPVDDKGSAKWKLGEDELSTILYLMDVCDDLVSAARFLVWLLPKIPINPIPTVHGGRNVMIVPRNVENQLCSVGETFVLSSLRRYENILAAANLIPETLSSMMNRASVVMASNGRVSGSAALVFARQMLKKYGHVATVGDWIKNFKTTADKRLVMELESGRSSDGEFGLPLGVPAGVQDFDEFLLKKISGVRISRVGLSMRDIVQRLVDEAISAFYGQEKKSFTGGPMKKPTVQKPDDGYLTAQQVVKGLMDCMRQTGGAAQEGDPTLVAFAVSAIVSNVGQVIAKITEITPVSLTFSRHIIRVHLTCLSLLKDALGERQSRVFEIALATEASSALSQVFSPPKASRGQLQLSPETRDPMSNENPTFSKAAKTTGAISALVIEAVLQGITSLERMVTVLRLKDGINVIQFLKSTRSNSNGNVRSIGDLKAENLVEVSVHWFRVLVGNCRTVSDGFIVDLLGESSIVALSRIQRVLPINLVFPPAFAIFGFLVWKRFIFNANIMARDNISQLFHSLRSAISDAIKHLPFRDVCLRECATLYDLVAADTSDSEFAEMLDLSGPDMHSKISAFVPLRARIFLNSIIDCQLPNEIISHDDGNRADLNEMKLLDRLVHILDTLQPAKFHWQWVELRLLLNEQALIGKVEARDTSLAEALRSFSPNNENVSDNENNFIQMVLTRLLVRPDAAPLFSEVVHLLGRSLEDEVLQQAKWFLRGHDVLFGRKSIRQRLINIAESKSLSTKIQFSKPWGWCNNNLSPMPGPVKKGNKRKFESVSLEEGEVVDDGNGTGPDTKRHSSRTFGPVSDVEAFIVSQQHVTEKALVELLLPCIDQSSNDSRFTFASDLIKQMNDIEQQISNVTHGVNKLLPVVSGGIEGPVTKVNTRKGLRGSSPGLARRLAGPVEMMLPSPSALRASISLRLQLLLRLLPVICADGEPSFRSLRHMLASVVLRLLGSRVVHEDADLYNPTSASVDLGESLYDRLLLVLHALLSTSQPYWLRPKSSSKATSEGSRDSNPYDREVAEKLQNELDGMQLPDAVRWQIQTVMPFVFHTARFSISCQPPNVPLSALGLLQPSVSIPIPHPGNHRNSQGPSSRAMSNGPGKASNSKPVSSQPDSDIEIDPWTLLEDGAGSGPSSINAAAIAGTDHANLKASSWLKGAVRVRRMDLTYIGAIDDDS
Length2148
PositionKinase
OrganismHelianthus annuus (Common sunflower)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Heliantheae alliance> Heliantheae> Helianthus.
Aromaticity0.07
Grand average of hydropathy-0.229
Instability index46.52
Isoelectric point9.01
Molecular weight238773.74
Publications
PubMed=28538728

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14516
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.59|      13|      29|     505|     521|       1
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  505-  521 (22.48/23.51)	F.CDETFDKRWiadvSTC
  536-  549 (23.10/13.11)	FmCSVFFICEW....ATC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     369.80|     121|    1179|     558|     684|       2
---------------------------------------------------------------------------
  559-  684 (198.31/147.15)	PRGIKFSGKRDFSQVYVAT.RLLE....MKTRNMRSSSRPKAGVRKVKD..LSQFFQSPGPLHDIIV.CwIDQHQAQSgeGFKRVQLLINEL..IRSGIFYPQAYVREL..IVS.GIMGMVDFDRKRRHFKllKHLPGL
 1732- 1865 (171.49/106.84)	PGPVKKGNKRKFESVSLEEgEVVDdgngTGPDTKRHSSRTFGPVSDVEAfiVSQQHVTEKALVELLLpC.IDQSSNDS..RFTFASDLIKQMndIEQQISNVTHGVNKLlpVVSgGIEGPVTKVNTRKGLR..GSSPGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     249.06|      52|     129|    1158|    1209|       3
---------------------------------------------------------------------------
 1102- 1153 (61.58/41.85)	MLKKYG..H.....VATV.GDWIKNFKttadKRLVMELES...GRSSDG........EFGLPL..GVPAgVQD
 1158- 1209 (84.17/60.51)	LLKKISGVR.....ISRV.GLSMRDIV....QRLVDEAISAFYGQEKKS........FTGGPM..KKPT.VQK
 1214- 1262 (49.15/31.58)	YLTAQQVVKglmdcMRQT.GGAAQEGD....PTLVAFAVSAIV.....S........NVGQVI..AKIT....
 1285- 1343 (54.17/35.73)	LLKDALGER.....QSRVfEIAL........ATEASSALSQVFSPPKASrgqlqlspETRDPMsnENPT.FSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.47|      46|     516|     227|     273|       4
---------------------------------------------------------------------------
  227-  273 (74.69/63.25)	PGSSSTSSGSPDRTRFSRsEQW.......TKDVIEYLQHLLDEFVQKSNSHSTL
  723-  775 (71.77/55.17)	PKNNIVSNKPKNHQKFVK.DQWpvpspsnANRKIEEVMNSIAVLLHFSNSQSTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.47|      94|     341|    1547|    1662|       9
---------------------------------------------------------------------------
 1497- 1606 (142.42/114.26)	IKHLPFRDVCLRECATLYDLVAADTSDSE..FAEML...DLSGPDMHskisafvpLRARIFLNSIIDcQLPNEIISHDD..GNRAdlnemkLLDRLVHILDT......LQPAKfHWQWVELRL
 1614- 1728 (134.05/91.65)	IGKVEARDTSLAEALRSFSPNNENVSDNEnnFIQMVltrLLVRPDAAplfsevvhLLGRSLEDEVLQ.QAKWFLRGHDVlfGRKS......IRQRLINIAESkslstkIQFSK.PWGWCNNNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.44|      70|    1179|     880|     951|      10
---------------------------------------------------------------------------
  880-  951 (118.00/75.97)	SQGASTSHVCDSRVNCPHHRNGISNNDSDVPktTDSVTTVHLGDAS..SIGNVLKRVPLDEKRV.VVVWLMGTVR
 2060- 2132 (111.44/66.22)	SQGPSSRAMSNGPGKASNSKPVSSQPDSDIE..IDPWTLLEDGAGSgpSSINAAAIAGTDHANLkASSWLKGAVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14516 with Med12 domain of Kingdom Viridiplantae
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