<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14515

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQESVEFTTLVSRAVEESYLSLKELVEKSKGADMSDSEKKISILKYLVKTQQRMLRLNVLAQWCQQVPLIQYCQQLASTLSSHETCFTQAADNMFFMHEGLQQARAPIYDVPSAIEVLLTGTYQRLPKCTEDVGIQSSLTEKQQKPVLKKLDTIVRSKLLETTLPKEFSEVKIFDGTVNLCVPGEFNVLLTLGYRGHLSMWRILHLEILVGEKSGPVKLEETRRFVLGDDLERRMAASDTPFAILYSILHEFCVALIMDTVIRQVREIRVGRWKDAIRFELISDGNSGQSQSNAAGPMQVSQDGETDSGGLRTPGLKIIYWLDCDKNPGTSDSVSCPFIKIEPGPDLQIKCIHSSFVIDPVTNREAEFSVDHSCIDVEKLLLRAICCNKYTRLLEIYKELGRNSHIYRSGGDVILHRQVDQRGAEFNKDDNLDSDGQEEVLRVRAFGSSFFTLGINIRTGRYLLHSSRNIIASSSLRECEEALNQGSMTAAEAFISLRSKSLLHLFACIGRFLGLQVYEHGFSPVKVPKHALNGSNMLLLGFPDCGSSYFLLMQLEEDFRPLFKLLETQPDQSGKPDSSVTRVKNVDISHKHMLEGEPNLSLLDYNAPTSSANSSSDRSLLSDLVVESSGLSGFSSLVDEIFEQERRSSASSFSVQSYNHASGAMSSHIDNPNWNGSLYPMSNYKGWVASGSTSSITSRSTTMKKMAASKSDQDLASGSPHSVEVGSYITGGPRVSAASARGNAFRNPASTSDSTPDSHITHISRENGSRKRTLSDMLNLLPSLKSQNILEQTSKRRKLTNTTSTQNQLGSVSNVEKYSYVNLIAEANKGDAASSIYVSALLHVVRHCSLCIKHARLTSQMDALDIPYAEEAGLRTPSSNIWFKVPFASNDTWEHICLRLGKPGSMYWDVKISDQHFIDLFDLQKGSTSTPWGSNVRIANTSDIDSHIRYDADGVVLTYNSVEVDSVKKMVADIQRLFNARTFALGMRKLLIVRPDEKTEESRSNGDIRYSEQMRKAFKIEAVGLMSLWFSFGSGVSGVLARFVVEWESGKSGCTMHVSPDQLWPHTKFLEDFINGTEVSSLLDCIRLTAGPLHALAAATRPARAAPVSGVPGAASSVSTLSKPNAYGQMPNGSNPNAVHGPGSGANPGASAMLTAATVAGRGGPGIVPSSLLPIDVSFVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPTVGGSLPCPQFRPFIMEHVAQELNGLDPNFTGGQSTVGPTNSNNSVASSSPQLSTANGNRVGLAGPTMSRPGSQPVGFNRATNAMSASPNSPLVRRAPGTVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHNAQQQQNTSVTGQDELSQTEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQAQGSDIPPAQRSRIELCLENHTGLVTDGSLENSSASKSNIHYDRPHNAVDFGLTVVLDPAHIPHINAAGGAAWLPYCVSVRLKYSFGENPNVCFLGMEGSHGGMSCWLRVEDWELCKQRVIRTVDGSSGGDLNQGRLRTVADNVQKTLHNCLQGLRTGGGGVAGANST
Length1673
PositionTail
OrganismHelianthus annuus (Common sunflower)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Heliantheae alliance> Heliantheae> Helianthus.
Aromaticity0.07
Grand average of hydropathy-0.209
Instability index45.66
Isoelectric point7.12
Molecular weight182783.31
Publications
PubMed=28538728

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14515
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.80|      45|     280|     303|     374|       1
---------------------------------------------------------------------------
  311-  363 (67.90/90.37)	DSGGLRTPGLKIiyWLdcdKNP.GTSDSVSCPFIKI.EPGP...DLQIKCIHssFvID
  874-  923 (71.90/32.34)	EEAGLRTPSSNI..WF...KVPfASNDTWEHICLRLgKPGSmywDVKISDQH..F.ID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     362.20|      96|     280|    1212|    1313|       2
---------------------------------------------------------------------------
  676-  747 (87.04/37.68)	................................PNWNGsLYPmsNYKGWVAS.GSTSSITSRSTTMKKMAASKSDQDLASGsPHSVEVGS.YITGGPRVS.AASARGN
 1100- 1179 (113.22/53.55)	LAAATrPARAAPVSG....VPGAASSVSTLSKPNAYG.QMP..NGSNPNAVHGPGSGANPGASAMLTAATVAG.R...GG.PGIV.PSSlLPI..............
 1213- 1313 (161.95/91.64)	LQPAT.PPKGGPTVGgslpCPQFRPFIMEHVAQELNG.LDP..NFTGGQSTVGPTNSNNSVASSSPQLSTANGNRVGLAG.PTMSRPGS.QPVGFNRATnAMSASPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     340.05|     109|     566|     936|    1052|       4
---------------------------------------------------------------------------
  936- 1052 (165.60/157.55)	WGSNVRIANTSDID....SHIRY...DADGVVlTYNSVEVDSVKKMVADIQRLFNARTFALgmrkLLIVRPDEKTEESRSNGD..IRY..SEQMRKAF.KIEAVGLMSLWFSFGsGVSGVLaRfVVEWE
 1499- 1619 (174.45/133.51)	WKKGLAQAQGSDIPpaqrSRIELcleNHTGLV.TDGSLENSSASKSNIHYDRPHNAVDFGL....TVVLDPAHIPHINAAGGAawLPYcvSVRLKYSFgENPNVCFLGMEGSHG.GMSCWL.R.VEDWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.68|      58|     419|     100|     184|       5
---------------------------------------------------------------------------
   36-   98 (86.71/41.53)	ADMSDSEKKISILkyLVKTQQRMLRL..NVLAQWC....QQVPLIqycQQLASTLSSH..ETCFTQAADNM
  110-  175 (82.97/93.68)	APIYDVPSAIEVL..LTGTYQRLPKCteDVGIQSSltekQQKPVL...KKLDTIVRSKllETTLPKEFSEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.30|      25|     357|    1075|    1099|      10
---------------------------------------------------------------------------
 1075- 1099 (43.60/30.93)	EDFINGTEVSSLLDCI..RLTAGPLHA
 1447- 1473 (39.69/27.43)	QDELSQTEISEICDYFsrRVASEPYDA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14515 with Med14 domain of Kingdom Viridiplantae
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