<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14512

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLHQVSWFQLLPNESDPILSDRSLKSNQKDTGAQLVISSHLQLQKDGFLSTWGNSFVGPWDPSQGLHNPDEKIKLWLFIPGRHSSVVDKAKAAVSKLRVFASGLWLAPGDSEEVAAALSQALRNCIERALMGLSYVRFGDVFSRYHSSSQGEELFRRGQPVLEFIFTATEEAVFVHVIISAKHVRALTNGDMETILKRTSSHSGVKLPVIVAPHGMRGRITGICPGDLVKQLYISSGKFKAINGIVGLPNQFSQSSGCQLRGQNCYIEVTLGCENAESEKSLPPNSNTSSKNHVSESSSVAKENEKTFIYPAEAVLVPLVQTSSARSSLKRFWLQNWMGQSLSSSSFSMQCDAFGTMDGSWHDNDMQTQHGYNSSGNSNSSSISTSSSSDSDYRMTGETGDLEADADSLSCMKSGLTTADQMHIDGSKLGSKRSRTGMTESYGQAGAIGNASMQEGYNSMEINNDQGGSQWDWDDDDKGVVMDIQALLSEFGDFGDFFENDVLPFGEPPGTEESQTPMFSATDGGDASSSPFTGMIDSSDPMILPVGFSSFESFNPPSTVVEESISKNQETTKDALSSGSMNYNPPPPPTSTEFDYLIKAEALMTFAPEYGAVETPTTDLLSSVIKSPYVPKSRTAESANSSTSSYVYSAIPPHHDASDDKSKPTIGVNSKDKYLLQSRKYYTHVESGKNDKKDEKPPSRDNIVDDVAPSALSLSGFNSSNAGLRASTRNKITESFLVSSKMAIANELECIMFQAFMCKIRHTLLTPTSSLQMNRLSGSNVLYQMHGESNVLSDNISNKYDIKKKETIPVRIAGDLDSGLLDGPLNPPVGVWRTVGVTKGSKSMTQGMEPFGSLPHNSFNEEGMLSYGQRQPLFELLDGLPLLFQQATSFVDVTLDADCGDGPYGWLAMQEQLRRGFSCGPSLVHAGCGGVLSSCHALDIAGVELADPLSADVHASYAITLLQSDIKSALKSAFGTFDGPLTVSDWCKGRNGQTDVFSAESSASINDSSVEPISPSQSADGTRVDDISESEQQLGLRPALLVIPIPAILVGYQDDWLKTSATSLQHWEKAPFEPYAMQKHMNYCVICPDIDPLTTAAADFFQQLETVYETCKLGTHSPQNFGNQTAKDSGKWSSSGFVLLDCPQSMKIESDSASLVGSISDYFLSLSNGWDLTSFLKSLSKVLKALKLGSCFAPNSKEGNSTPCTVIYVVCPFPEPVAVLKTIVESCVAIGSVVFPSSDKERRTAMQNQVGKALSCSTAVDEASISNVVTISGFSIPKLVLQIVTVDAIFRVTSPSLNEPVILKEIAFTVYNKARRISRGSSADVIPSVSVSGRSQSHSSMMQMNSPVPGMWKDSIGSRMGSREGELDASLRAGVWDNSWQMSRSDRPGEYYFQDELKYMFEPLFILAEPGSSERGVSPESLKLLTDDGTSSDTGLGSQMDGSDDGFGSGHQKQPPSLHCCYGWTEDWRWLVCIWTDSRGELLDSCTFPFGGISSRQDTKGLQFLFVQILQQGCQILQACSSDTNTARPHDFVITRIGSFFELECQEWQKALYSIGGSEVKKWSLQLRRSVPDGIAASSNGGPLQQQEMSMIQDRSLQSHGKGSNYMKGGLGQPMSRKQLLSGGSGGSHIAMDNSKGLLQWVQSITFVSVSVDHSLQLVYQADSSPGTTQGSGIMGQSCYVEGFTPVKSLGSASTSYIFVPSPSMRFLPPNPLQLPTCLTSESQPLAHLLHSKGSAIPISTGFVVSKAVPSMRKDSRSNCKEEWPSVLSVGLFDYYGGNSNNNNNNGSNNNNNNEKAKNIGKSGMENHLILERVAAELHALSWMTVSPGYLERRTALPFHCDMVLRLTRLLHFADKELSQLSVKSEV
Length1876
PositionKinase
OrganismHelianthus annuus (Common sunflower)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Heliantheae alliance> Heliantheae> Helianthus.
Aromaticity0.08
Grand average of hydropathy-0.310
Instability index49.17
Isoelectric point5.32
Molecular weight203583.07
Publications
PubMed=28538728

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14512
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1146.24|     344|     409|     269|     637|       1
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  271-  637 (555.21/368.44)	GQNCYIEVTLGCENAESEKslPPnsntsSKNHVSESSSVAKENEKTFiYPAEAVLvplvqTSSARSSL.KRFWLQNWM..GQSLSSSSF.SMQCDAFGTMDGSWHDNDMQTQHG....YNSSGNSNSSSISTSSSSDSDYRMTGETgDLEADADSLSCMKSGLT.TADQMH.IDGSKLGSKRSRTGMtESYGQAGaiGNASMQEGYnsmeINNDQGGSQWDWDD......DDKGVVMDIQALLSEFGD..FGDFFENDVLPFG.EP......PGTEE...SQTPMFSATDGGDASSSPFTGM..IDSSDPMILPVGFSSFESFNPPSTVveESISKNQETTKD...ALSSGSMNYNPPPPPTSTEFDYLIKAEALMTFAPEYGAVETPTTDLLSS...........VIKSP
  687- 1055 (510.17/297.85)	SRKYYTHVESGKNDKKDEK..PP.....SRDNIVDDVAPSALSLSGF.NSSNAGL.....RASTRNKItESFLVSSKMaiANELECIMFqAFMCKIRHTLLTPTSSLQMNRLSGsnvlYQMHGESNVLSDNISNKYDIKKKETIPV.RIAGDLDS.GLLDGPLNpPVGVWR.TVGVTKGSKSMTQGM.EPFGSLP..HNSFNEEGM....LSYGQRQPLFELLDglpllfQQATSFVDV.TLDADCGDgpYGWLAMQEQLRRG.FS......CG........PSLVHAGCGGVLSSCHALDIagVELADPLSADV.HASYAITLLQSDI..KSALKSAFGTFDgplTVSDWCKGRNGQTDVFSAESSASINDSSVEPISPSQSADGTRVDDISESeqqlglrpallVIPIP
 1349- 1466 (80.87/35.29)	..........................................................................................................................................................SMMQMNSPVP...GMWKdSIGSRMGS...REG..................................ELDA......SLRAGVWDNSWQMSRSDR..PGEYYFQDELKYMfEPlfilaePGSSErgvSPESLKLLTDDGTSSDTGLGSQ..MDGSDD.....GFGSGHQKQPPS....................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     274.65|      87|     409|    1060|    1212|       2
---------------------------------------------------------------------------
 1110- 1212 (138.39/144.03)	FQQLETVYETCKLGTHS..PQNF.....GnqtakdsgkwsssGFVLLDCPQSMK.........IESDSASLVGSISDYFLSLSNGWDLTSFLKSL..SKVLKALKLGSCFApnsKEGNSTP
 1519- 1623 (136.26/52.29)	LQQGCQILQACSSDTNTarPHDFvitriG.............SFFELECQEWQKalysiggseVKKWSLQLRRSVPDGIAASSNGGPLQQQEMSMiqDRSLQSHGKGSNYM...KGGLGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.29|      25|     407|    1280|    1306|       3
---------------------------------------------------------------------------
 1280- 1306 (33.90/30.30)	ISGFSiPKLVLQIVTVDAIFrVTSPSL
 1690- 1714 (45.39/29.62)	VEGFT.PVKSLGSASTSYIF.VPSPSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.78|      11|      27|      84|      95|       4
---------------------------------------------------------------------------
   84-   95 (18.10/14.05)	LWLfIPGRHSSV
  113-  123 (21.67/11.22)	LWL.APGDSEEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.86|      24|      29|     176|     199|       5
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  176-  199 (38.23/25.77)	TATEEAVFVHVIISAKHVRALTNG
  208-  231 (41.63/28.75)	TSSHSGVKLPVIVAPHGMRGRITG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14512 with Med13 domain of Kingdom Viridiplantae
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