<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14498

Description Putative cyclin-dependent kinase E-1
SequenceMSNRGNNSGSGTNSNTNSPNRPEWLQQYDLIGKIGEGTYGLVFLAKIKSNRSKCIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLVNVHINHIDMSLYLAFSYAEHDLYEIIRHHRDKVNQAINQYTVKSILWQLLNGLNYLHSNWIMHRDLKPSNILVMGDGEEQGVVKIADFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKATPNPFQLDQLDKIFKVLGHPTVDKWPTLAHLPHWQTDQQHIQGHKYDSPGLYSVVHLSPKNPAYDLLCKMLEYDPRKRITAAQALEHEYFRMEPLPGRNALVPPQPGEKIVNYPIRPVDTNTDFEGTASLQPAQQASGNQMSGGSHVMANRNVQRPVHMVGGMQRMQQQQSMAAYNLASQAAGMGGGAMNPGNIPMQQRGVAAQPHQQQQQQQQKEGPNGDAWISATEVKAFLREYEVVK
Length486
PositionKinase
OrganismHelianthus annuus (Common sunflower)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Heliantheae alliance> Heliantheae> Helianthus.
Aromaticity0.08
Grand average of hydropathy-0.469
Instability index39.10
Isoelectric point8.82
Molecular weight54473.50
Publications
PubMed=28538728

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14498
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.17|      38|      42|     375|     416|       1
---------------------------------------------------------------------------
  357-  378 (23.57/ 8.64)	....................V...NYPIRPVDTNTDFEGTASLQP
  379-  420 (61.15/50.56)	AQQASGnqMSGGShvMANRNV...QRPVHMVGGMQRMQQQQSMAA
  424-  460 (51.45/30.50)	ASQAAG..MGGGA..MNPGNIpmqQRGVAAQPHQQQQQQQQ....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.02|      28|      42|     164|     193|       2
---------------------------------------------------------------------------
  164-  193 (43.82/34.84)	LVMGDGEEQGVVKIADFGLarIYQA..PLKPL
  209-  238 (45.20/29.44)	LLLGAKHYTSAVDMWAVGC..IFAEllTLKPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.18|      16|      41|     290|     308|       3
---------------------------------------------------------------------------
  290-  308 (26.75/21.67)	HKY....DSPGLYSVVhlsPKNP
  333-  352 (27.43/14.02)	HEYfrmePLPGRNALV...PPQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14498 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPLPGRNALVPPQPGEKIVNYPIRPVDTNTDFEGTASLQPAQQASGNQMSGGSHVMANRNVQRPVHMVGGMQRM
2) QQQSMAAYNLASQAAGMGGGAMNPGNIPMQQRGVAAQPHQQQQQQQQKEGPNGDAWISA
339
414
412
472










Molecular Recognition Features






MoRF SequenceStartStop




1) GDAWISATEVKAFLREYEVVK
466
486