<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14427

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASELGQQTVEFSTLVNRTAEESFLSLKELVEKSKAAQDQSDTDKKIGLLKYLAKTQQRMLRLNVLAKWCQQVPLIQYCQQLSSTLSSHDTCFTQAADSLFFMHEGLQQACAPVYDVPSAIDILLTGSYQRLPKCVEDVGVQSSLSEDKQQPALKKLDTLVRSKLLEVSLPKEISEVKVSDGTAVLRVNGEFKVLVTLGYRGHLSMWRILHLELLVGERCGLVKLEESRRHALGDDLERRMAAAENPFTTLYSVLHELCVALVMDTVIRQVQALRQGRWKDAIRFELISDGSTSHGGSTASAQLNQDGENDSSGLRTPGLKILYWLDFDKNNGISDSASCPSIKIEPGPDLQIKCLHSTFVIDPLTGKEAEISLDQNCIDVENLLLRAICCNRYTRLLEIQKDLGKNAQIYRGKGDVSLESHVEDVDVDHKKKDDNSNVREYEGQEVLRVRAYGSSFFTLGINIRNGRFRLQSSPNILASSEFLSECEDALNQGSMTAAEVFINLRSKSILHLFASIGRFLGLEVYEHGFPAVKVPKNILNGSTELLMGFPDCGSSYFLLMQLDKDFKPLFKLLETQPGPSGKADSCHDLNHVIRIKKIDVSQMQMHEDDMNLSLLDWGKLHSFLPSAGGSNRSSENGLLSDISHGGSMPIAGCAPSSFSSVVDEVFELEKGLSVPSYSIPNVSSSLNASPASHFGSGPMNLHTIKAGSASPKWEGGMQLSQLNNSVNVSSMPTHYNGSLYSSNNLKGPIQSASLGSLSSGPGRSASVKKIPISKSDQDLASLRSPQSVEYGSCTSMDEDQLRFLNDTSKGALYGNRSSLILSPTRSTGPRISGPGVRPNGAITGSFRVVGLNSCATTPGSQAPDSGVCHSPNQDVSNRKPRKRTLSDMLNLIPSLQCVEANPGFCRRRKISEVARPQQSSSQMLMPRDIISKSEVYSYGDLISEANKGNAPSSIYVSALLHVVRHCSLGIKHARLTSQMGALDIPYVEEVGLRSISSNIWFRLPFARGDSWQHLCLRLGRPGSIYWDVKINDQHFRDLWELQKGSNSTPWGSGVRIANTSDIDCHIRYDPEGVVLSYQSVEADSIKKLVADIQRLSNARMFALGMRKLLGVRADEKPEESNTHSDFKAPGVKGSFEAADRLSEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARASPIPGVPGGAVLSSIPKLVGQSPSQGLMPTSSTTNASQSPSGPMGNSVSSTATGPLANHSLHGAAVLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLDTNFTAGQQTGLASSISQNPTSGSQLSAVNGNRVNLPGSAAMSRTGNQVAVLNRVGNASPVSSNLAVVSSGMPLRRSPGPGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQQQPNSTTAQEELSPSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQAQGGDGAPAQKPRIELCLENHAGSSMDENSDNSSVAKSNIHYDRPHNSVDFALTLVLDPAHIPHINAAGGAAWLPYCVSVRLRYAFGENPNVSFLGMEGSHGGRACWLRIDDWEKCKNKVARTVELNGSSGGDSSQGRLRIVADYVQRTLHMWLQGLRDGGGVSASSGAT
Length1826
PositionTail
OrganismPrunus persica (Peach) (Amygdalus persica)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Rosaceae> Amygdaloideae> Amygdaleae> Prunus.
Aromaticity0.06
Grand average of hydropathy-0.221
Instability index45.99
Isoelectric point7.69
Molecular weight198192.76
Publications
PubMed=23525075

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14427
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     110.96|      26|      72|     738|     763|       1
---------------------------------------------------------------------------
  749-  785 (31.04/13.24)	PIQSASL.GS.......LSSGPGrsasvkkipisksDQD.L..A...S..LRS
  786-  811 (27.72/10.94)	P.QSVEY.GS.......CTS.............mdeDQLrF..L...NDTSKG
  824-  845 (31.56/13.60)	PTRST...GP.......RISGPG..................vrP...NGAITG
 1289- 1327 (20.63/ 6.03)	PLANHSLhGAavlaaagR.GGPG..........ivpSSL.L..PidvSVVLRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     246.67|      96|     353|     287|     384|       2
---------------------------------------------------------------------------
  287-  343 (70.74/42.07)	..............................................................LISDGSTS...HGGSTAS...........................................................................................................................................................................................................................aQLNQDGENDSSgLRTPGLKILYW...LDFDKNNGISDSASCPSI
  344-  384 (45.16/18.81)	KIEPGPDLQIK.CLHSTF..VIDPLTGKEAEISLDQNCIDVENL............................................................................................................................................................................................................................................................................................................
  605-  639 (24.73/ 6.83)	................................................................................llraiccnrytrlleiqkdlgknaqiyrgkgdvsleshvedvdvdhkkkddnsnvreyegqevlrvraygssfftlginirngrfrlqsspnilasseflsecedalnqgsmtaaevfinlrsksilhlfasigrflglevyehgfpavkvpknilngstellmgfpdcgssyfllmqldkdfkplfklletqpgpsgkadschdlnhvirikkidvsqmQMHEDDMN.........LSLLDWgklHSFLPSAGGSNRSSENGL
  642-  745 (106.04/55.69)	DISHGGSMPIAgCAPSSFssVVDEVFELEKGLSVPSYSIPNVSSslnaspashfgsgpmnlhTIKAGSASpkwEGGMQLS............................................................................................................................................................................................................................QLN.NSVNVSS.MPTHYNGSLY.......SSNN...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.55|      31|     353|     919|     949|       3
---------------------------------------------------------------------------
  919-  949 (54.98/32.01)	QSSSQMLMPRDII...SKSEVYSYGDLISEANKG
 1255- 1288 (50.56/28.79)	QSPSQGLMPTSSTtnaSQSPSGPMGNSVSSTATG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.86|      20|     353|    1160|    1205|       4
---------------------------------------------------------------------------
 1181- 1205 (31.87/64.43)	EGCTMHVspDQLWPHTKFledFING
 1538- 1557 (35.99/ 9.97)	EGALLNL..DQEQPALRF...FVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.12|      37|     353|     991|    1048|       5
---------------------------------------------------------------------------
  386-  425 (61.40/29.56)	LRAICCNRYTRLLEIQKD........LGKNAQIYRgkgDVSL.ESHVED
  993- 1038 (59.72/67.02)	LRSISSNIWFRLPFARGDswqhlclrLGRPGSIYW...DVKInDQHFRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.73|      18|     230|    1219|    1241|       6
---------------------------------------------------------------------------
 1224- 1241 (33.44/27.61)	ALAAATRPARASPIPGVP
 1455- 1472 (35.29/15.52)	AVVSSGMPLRRSPGPGVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.67|      10|      36|     132|     141|       8
---------------------------------------------------------------------------
  132-  141 (18.79/13.34)	LPKCVEDVGV
  170-  179 (16.88/11.07)	LPKEISEVKV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14427 with Med14 domain of Kingdom Viridiplantae
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