<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14390

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLHQISWFQFLPHDSELIPQPDKSSVKDAATQLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPDEKIKLWLFLPGRHSSYADPAQAAVSKLRVVASGLWMSPGDSEEVATALSQALRNRIERALSGLAYMRFGDVFSKFHASQSEELLRRGQPTVEFIFAATEEGIFVHALVSAKHIRALSSDDLERVQKHSSQNSCYGLPVIVSPHGICGRLTGCCPGDLVKQVYFSSSKLKTSNFIGLPNHVSQGSGSQLTWQNCYVEVTLGCPRPRSDRALQSNSNSFRNVVKHHPVESPSLGRGDQKGSLDNISVYEKTFVYPAEAVLVPSLQVAGSSLKRFWLQNWIGPSMPGSSFFMLCSDSIEPMEECNETNGIRTQRGYNSSSNSNSSSISSISSSSSDSDDKMATGASELEADADSLTCRQSGLSFNNRLGNDISKLGFKRPRDGMAESFAEVGTATSASLQDTYNSDFGSMEVNNSAITVVTNDQIGSLWDWDGDDRYGTDIHALINEFGDFGDLFESDVLPFGEPPGTTESQALMFSAPDFGDVVDNPVGVMDVSDQLLLSEGFASFESFIPPPPAAMEETLIKNQEAINSALSSGPVNCSSASNISEFDHIIKAEALMTFAPEYGAVETPTSEVSSSIFRSPYLPKSRKAESSNSSPSIYTYGPTPPSSCFDGFDEKTGIPSNSKPFAGKKDASNIFRSKNYYTHVESGKEQQDRRLLTSSNGIVVAHDGVAQSPFPVLNSTNAVKAAQRKMTEGTFESENSFLSMRTIPATEIECILFQASMCRIRHTLLSSSSLSSIGFSRLPGDQTVMPENISGKYEARRKESIPVRIAGDIDGGMIDGHLNAPVGVWRSVGAPRVPKPTSSSSMEISSSLPHTSFNDESMLSYGRQPLQELLDGLSLLVQQATSFVDLALDSDCSDGPYGWLALQEQWRKGFSCGPSMVHAGCGGTLASCHSLDIAGVELVDPLSADVHASSVISLLQSDIKTALKSAFGILDGPLPVTDWCRGRNQSGESTVDGYSAESTISECKDSSSIVAPSIIEPLSPSPSCSAGSTCLKVSSAMDGAKVDETSQRRSNQENCTSESDLQMSSRLRPTLFVIPLPAILVGYQDDWLKTSASSLQLWEKAPLEPYALQKPITYYVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHLPQSFGSQMEVDSGRRPSSGFVLLDCPQAMKIESRNASLVGSLSDYFLSISNGWDLTSYLKSLSKALKALKLGHCLSTNAKEGSSGPSTVIYVVCPFPEPIAILQTVIESSVAIGSVIFQSDRERRSILYSQVSKALSYSATVDEASISNILVLSGFGIPKLVLQIVTVDAIFKVTSPSLNELVILKETAFTVYNKARRISRGASSDAVQSSLSSRSHTVLSQMSSPTPGTWKDCGGPRITGHSLPREGEMDASLRTGSWDSSWQTTRTGAANCDPNRIGDFFSQDETRYMFEPLFILAEPGSLERAFSPLAFGNLPSEPSKALSDDISGGFMQSTSLGGSADSGSGSQADGSELDKIPPSLHCCYGWTEDWRWLICIWTDSRGELLDSHIFPFGGISSRQDTKGLECLFVQVLQQGCQILQACSSDTGVAKPRDFVIARIGSFYELEYQEWQKAINSVGGSEVKKWHLQLRRSVSDGVSASSNGPSLQQQEMSLIQERTLPSSPGPLYGSSHSKISGFMKGGLGQPSVRKQLMGTQLIDSSRSLLQWVQSISFITIAIDHSLHLVFPADTQSPGAQGGVGVGSSGYLEGFTPVKSLGSTPAAYILIPSPSMRFLPPTPLQLPTCLTAESPPLAHLLHSKGSAIPLSTCFVVSKAVPTMRRDYRSNLKEEWPSTLLVSLIDHYGGNNFSQEKLMRGNTKQVGRSPSSEARELEIETHVILESLAAELHALSWMTVSPAYLERRTALPFHCDMVLRLRRLLHFADKDLSRHQEKP
Length1962
PositionKinase
OrganismPrunus persica (Peach) (Amygdalus persica)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Rosaceae> Amygdaloideae> Amygdaleae> Prunus.
Aromaticity0.08
Grand average of hydropathy-0.233
Instability index56.87
Isoelectric point5.41
Molecular weight212639.53
Publications
PubMed=23525075

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14390
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     308.09|      79|     172|    1011|    1121|       1
---------------------------------------------------------------------------
 1011- 1089 (137.50/61.47)	LDGPLPVTDWCRGRNQSGESTVDGYSAEST.ISECKDSSSIVA..PSIIEPLSPS.PSCSAG...STCLK.VSSAMDGAKVDETSQR
 1185- 1261 (88.69/33.16)	LGTHLPQSFGSQMEVDSGRRPSSGF....V.LLDCPQAMKIESrnASLVGSLSDYfLSISNGwdlTSYLKsLSKALKALKLG.....
 1661- 1718 (81.91/31.54)	..................RSVSDGVSASSNgPSLQQQEMSLIQ..ERTL.PSSPG.P..LYG...SSHSK.ISGFMKGG.LGQPSVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.49|      25|      28|     500|     527|       2
---------------------------------------------------------------------------
  503-  527 (50.83/35.05)	WDWD....GDDRYGTDIHALINEFGDFGD
  529-  557 (41.67/19.83)	FESDvlpfGEPPGTTESQALMFSAPDFGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.85|      27|      28|      87|     113|       3
---------------------------------------------------------------------------
   83-  111 (42.46/20.16)	WLflPGRHSSYADP.AQAAVSKLRVVASGL
  112-  140 (38.39/17.61)	WM.sPGDSEEVATAlSQALRNRIERALSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     779.09|     267|     611|     659|     977|       4
---------------------------------------------------------------------------
  242-  498 (296.94/146.12)	SSKLKTSNfiglpnhvsqGSGSQLTW.....QNCY..VEVTLGCP...RPRSDRalQSNSNSFRNVVKHHPVESpslGRGDQKGSLDNISvyeKTFVYPAEAVLVPSLQVAGSS..LKRFWLQNWIGPSMPGSSFfmLCSDSIEPME.ECN..ETNGIRTQRGYNSssnsnSSSISSISSSSSDSDDK.MATGAS.ELEA.DADSLTCRQSGlsfnnrlgndisklgfkRPRDGMAESF..AEVGTATSASLQDTYN.SDFGSMEVNNSAITVVTNDQ.......................................................
  662-  951 (404.84/302.31)	SRKAESSN..........SSPSIYTYgptppSSCFdgFDEKTGIPsnsKPFAGK..KDASNIFRSKNYYTHVES...GKEQQDRRLLTSS...NGIVVAHDGVAQSPFPVLNSTnaVKAAQRKMTEGTFESENSF..LSMRTIPATEiECIlfQASMCRIRHTLLS.....SSSLSSIGFSRLPGDQTvMPENISgKYEArRKESIPVRIAG.................DIDGGMIDGHlnAPVGVWRSVGAPRVPKPTSSSSMEISSSLPHTSFNDESMLSYGRQPLQELLDGLSLLVQQATSFV.DLALDSDCSDgpYgWLALQEQWRKGF
 1774- 1863 (77.32/21.46)	.........................................................................................................................................................................................................................................GYLEGF..TPVKSLGSTPAAYILIP..SPSMRF...LPPTPLQLPTCLTAESPPLAHLLHSKGSAIPLSTCFVvSKAVPTMRRD..Y.RSNLKEEWPSTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.22|      26|     173|    1096|    1121|       5
---------------------------------------------------------------------------
 1096- 1121 (46.82/30.59)	CTSESDLQMSSRLRPTLFVI.PLP...AIL
 1263- 1292 (37.40/22.66)	CLSTNAKEGSSGPSTVIYVVcPFPepiAIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14390 with Med13 domain of Kingdom Viridiplantae
Unable to open file!