<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14389

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAESFAEVGTATSASLQDTYNSDFGSMEVNNSAITVVTNDQIGSLWDWDGDDRYGTDIHALINEFGDFGDLFESDVLPFGEPPGTTESQALMFSAPDFGDVVDNPVGVMDVSDQLLLSEGFASFESFIPPPPAAMEETLIKNQEAINSALSSGPVNCSSASNISEFDHIIKAEALMTFAPEYGAVETPTSEVSSSIFRSPYLPKSRKAESSNSSPSIYTYGPTPPSSCFDGFDEKTGIPSNSKPFAGKKDASNIFRSKNYYTHVESGKEQQDRRLLTSSNGIVVAHDGVAQSPFPVLNSTNAVKAAQRKMTEGTFESENSFLSMRTIPATEIECILFQASMCRIRHTLLSSSSLSSIGFSRLPGDQTVMPENISGKYEARRKESIPVRIAGDIDGGMIDGHLNAPVGVWRSVGAPRVPKPTSSSSMEISSSLPHTSFNDESMLSYGRQPLQELLDGLSLLVQQATSFVDLALDSDCSDGPYGWLALQEQWRKGFSCGPSMVHAGCGGTLASCHSLDIAGVELVDPLSADVHASSVISLLQSDIKTALKSAFGILDGPLPVTDWCRGRNQSGESTVDGYSAESTISECKDSSSIVAPSIIEPLSPSPSCSAGSTCLKVSSAMDGAKVDETSQRRSNQENCTSESDLQMSSRLRPTLFVIPLPAILVGYQDDWLKTSASSLQLWEKAPLEPYALQKPITYYVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHLPQSFGSQMEVDSGRRPSSGFVLLDCPQAMKIESRNASLVGSLSDYFLSISNGWDLTSYLKSLSKALKALKLGHCLSTNAKEGSSGPSTVIYVVCPFPEPIAILQTVIESSVAIGSVIFQSDRERRSILYSQVSKALSYSATVDEASISNILVLSGFGIPKLVLQIVTVDAIFKVTSPSLNELVILKETAFTVYNKARRISRGASSDAVQSSLSSRSHTVLSQMSSPTPGTWKDCGGPRITGHSLPREGEMDASLRTGSWDSSWQTTRTGAANCDPNRIGDFFSQDETRYMFEPLFILAEPGSLERAFSPLAFGNLPSEPSKALSDDISGGFMQSTSLGGSADSGSGSQADGSELDKIPPSLHCCYGWTEDWRWLICIWTDSRGELLDSHIFPFGGISSRQDTKGLECLFVQVLQQGCQILQACSSDTGVAKPRDFVIARIGSFYELEYQEWQKAINSVGGSEVKKWHLQLRRSVSDGVSASSNGPSLQQQEMSLIQERTLPSSPGPLYGSSHSKISGFMKGGLGQPSVRKQLMGTQLIDSSRSLLQWVQSISFITIAIDHSLHLVFPADTQSPGAQGGVGVGSSGYLEGFTPVKSLGSTPAAYILIPSPSMRFLPPTPLQLPTCLTAESPPLAHLLHSKGSAIPLSTCFVVSKAVPTMRRDYRSNLKEEWPSTLLVSLIDHYGGNNFSQEKLMRGNTKQVGRSPSSEARELEIETHVILESLAAELHALSWMTVSPAYLERRTALPFHCDMVLRLRRLLHFADKDLSRHQEKP
Length1505
PositionKinase
OrganismPrunus persica (Peach) (Amygdalus persica)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Rosaceae> Amygdaloideae> Amygdaleae> Prunus.
Aromaticity0.08
Grand average of hydropathy-0.194
Instability index58.05
Isoelectric point5.11
Molecular weight162556.98
Publications
PubMed=23525075

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14389
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1240.77|     325|     343|     527|     869|       1
---------------------------------------------------------------------------
  527-  817 (440.84/307.98)	........................................................SAD.VHASSV.ISLLQSDIKTALKSAFGI.........LDGPL......PVTDWCRG.......RNQ...SGESTVDGYSAESTISECKDS....SSIVAPS.IIEPLS...PSPSCSAGSTClkvssAMDGAKVDETSQRRSNQENCTSESDLQMSSRLRPTLFV.IPLPAI.LVGYQDDWLKTSASSlQLWEKAPL....EPYALQK....PI.TYYVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHLPQSFG....SQ...M...EVDS...GRRPSS.....GFV....LLDCPQAMKIESRNASLVGSLSDYFLSISNGWDlTSYLKSLSkALKALKLGHCLSTNAKEGSSG
  818- 1160 (422.31/298.83)	P.STVIYVVCPFPE.PIAILQTVIeSSVAiGSVIFQSDRE.RRSIlySQvskalsySAT.VDEASI.SNIL.......VLSGFGIpklvlqivtVDAIF......KVTS..PS.......LNElviLKETAFTVYNKARRISRGASSdavqSSLSSRShTVLSQM...SSPTPGTWKDC.......GGPRITGHSLPREGEMDASLRTGSWDSSWQTTRTGA.ANCDPN.RIG...DFFSQDETR.YMFE..PLfilaEPGSLER.afsPL.AFGNL.PS.EP.SKALSDDIS..GGFMQSTSLGGSADSGSG....SQ...AdgsELD.....KIPPSlhccyGWTedwrWLIC...IWTDSR.GELLDSHIFPFGGISSRQD.TKGLECL..FVQVLQQG.CQILQACSSDTG
 1164- 1481 (377.62/246.22)	PrDFVIARIGSFYElEYQEWQKAI.NSVG.GSEVKKWHLQlRRSV..SD..........gVSASSNgPSLQQQEMSLIQERTLPS.........SPGPLygsshsKISGFMKGglgqpsvRKQ..lMGTQLID..SSRSLLQWVQ.S....ISFITIA.IDHSLHlvfPADTQSPG........AQGGVGVGSSGY....LEGFTPVKSLGST....PAAYIlIPSPSMrFLPPTPLQLPTCLTA....ESPPL....AHLLHSKgsaiPLsTCFVVSKAVPTMRR...DYRSNLKEEWPSTLL.VSLIDHYGgnnfSQeklM...RGNTkqvGRSPSS.....EAR....ELEIETHVILESLAAEL.HALS..WMTVS.....PAYLERRT....ALPF.HC...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.71|      25|     398|      26|      80|       2
---------------------------------------------------------------------------
   52-   76 (43.47/54.15)	DRYGTDIHALINEFGDFGDLFESDV
   82-  106 (46.23/23.03)	PPGTTESQALMFSAPDFGDVVDNPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.50|      26|     124|      17|      42|       3
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   17-   42 (45.22/30.81)	QDTYNSDFGSMEVNNSAITVVTN.DQI
  143-  169 (40.28/26.50)	QEAINSALSSGPVNCSSASNISEfDHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.35|      16|      27|     211|     236|       4
---------------------------------------------------------------------------
  211-  229 (28.10/30.49)	SNSSPsiyTYGPTPPSSCF
  240-  255 (29.25/ 8.42)	SNSKP...FAGKKDASNIF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14389 with Med13 domain of Kingdom Viridiplantae
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