<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14357

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSTLVSRAAEESFLSLKELVDKSKSSDQSDSDKKLSLLKYLVKTQQRMLRLNVLAKWCQQVPLIQYCQQLQSTLSSHEACFTQTADSLFFLHEGLQQARAPIYDVPSAIEVLLTGSYQRLPKCIEDVGMQSTLTEEQQKPALKKLDTLVRSKLLEVTLPKEISEVKISDGTALLRVNGEFKVLVTLGYRGHLSMWRILHLELLVGERSGPVKLEELRRHALGDDLERRMAGAENPFMILYSVLHELCISLIMDTVIRQVQVLRQGRWKDAIRFELISDGSSGSTQLNQDGETDSAGLRTPGLKIVYWLDLDKNSGTSDSGTCPFIKIEPGSDLQIKCVHSTFVIDPINGREAEFSLDQSCIDVEKLLLRTICCNRYTRLLEIQKELGKNAQVFRAAGDVVLQSHMEEPDVDSKKKEIKNDGREYEGQEALLVRAYGSSFFTLGINIRTGRFLLRSSQSMLSPATLVEYEEALNQGSMTAAEVFINLRSKSILHLFASIGRFLGLEVYEQGFTIVKMPKTLLSGSTMLIMGFPDCGNLYFLHVQLDKDFKPLFKLLETQADPSAKSHSFNDSNHVMRIKKVDVSQMQIFEDELNLSLLDSGKLTGCLPAGGSSQTSEHGLLSEFSLEGPMQIAGCPPSSFSSVVDEIFEHEKGAAAPSFPLQNLTSYNASPASRFGSVPMNLHTAKAGTPSPKWEGGLQVSQMNNVVKVSNVASHYNGSLYPSNNVKGPMHSNSYSSLSSGLGRGTTVKKLSASKSDQDLASLRSPHSVEVGSSSSVDEDHLRLLNDTSMDALSGSRSSRLLSPSQSTGSRASTPGGKHSGLRSSPTGPLAGSVRGTGSSSLATTPVSQAAGDTAVFHGSGHNVSKPDKNPRKRTVSDMLNLIPSLQDTDSKAGFSKRKKTSESALSQQHSSQMLLASEMMFKNEGYSYGNLIAEANKGNAPSNIYVSALLHVVRHCSVCIKHARLTSQMDALEIPYVEEVGLRNASSNIWFRLPFARGDSCQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSSTTPWGSGVRIANTSDVDSHIRYDPEGVVLSYQSVEADSIKKLVADIRRLSNARMFALGMRKILGVRPDEKSDENSANSDVKLPAGCKSGVEATDKLSEQMRRAFKIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAGPAPGVPGVTSAIASMPKQAGYVQSQGVLGSSSANNVSQPTSVPVGNAVASSGTVPMGNISLHGSAMLAGAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKEGPKVGGSLPCPQFRPFIMEHVAQELNGLDPGFTGGQQTAGLANSNPSNPGSGSQLSGANGNRVNLPSSAVLSRAATQVAALNRVGNAVPGSSNLAVVSSGLPIRRPPGAGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNSATSQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLTQVQGGEIAPGQKPRIELCLENHAGINENDNSENSSAAKSNIHYDRPHSCVDFALTVVLDPAHIPHVNAAGGAAWLPYCVSVRLRYSFGENTNVTFLGMEGSHGGRACWLRVDDWEKCKQRVIRTVEINGCSTGDVTQGRLKMVADSVQRTLHLCLQGLRDGSGVAASSGAA
Length1825
PositionTail
OrganismManihot esculenta (Cassava) (Jatropha manihot)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Malpighiales> Euphorbiaceae> Crotonoideae> Manihoteae> Manihot.
Aromaticity0.06
Grand average of hydropathy-0.202
Instability index43.24
Isoelectric point7.96
Molecular weight197863.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14357
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.52|      19|      19|     761|     779|       1
---------------------------------------------------------------------------
  741-  758 (16.48/ 6.31)	..SNSYSSLSSgLGRGTTVK
  761-  779 (30.65/19.59)	SASKSDQDLAS.LRSPHSVE
  782-  800 (29.39/18.41)	SSSSVDEDHLR.LLNDTSMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.01|      20|      21|     632|     651|       2
---------------------------------------------------------------------------
  603-  622 (29.86/14.39)	NLSLLDSGKLTGCLPAGGSS
  632-  651 (37.87/20.39)	EFSLEGPMQIAGCPPSSFSS
  670-  686 (20.28/ 7.22)	...LQNLTSYNASPASRFGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.19|      13|      18|     806|     818|       3
---------------------------------------------------------------------------
  806-  818 (22.99/11.19)	RSS...RLLSPSQSTG
  832-  847 (18.21/ 7.28)	RSSptgPLAGSVRGTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.02|      11|      36|     397|     407|       4
---------------------------------------------------------------------------
  397-  407 (19.64/12.00)	GKNAQVFRAAG
  436-  446 (19.38/11.75)	GQEALLVRAYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.59|      15|     612|     687|     701|       7
---------------------------------------------------------------------------
  687-  701 (31.07/15.77)	VPM...NLH....TAKAGTPSP
 1289- 1310 (19.52/ 7.41)	VPMgniSLHgsamLAGAGRGGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     223.60|      65|     110|     155|     236|       8
---------------------------------------------------------------------------
  155-  219 (107.44/59.89)	LDTLVRS.KLLEVTLPKEISEVK.ISDGTA...LLRVNGEFKV..LVTL..GYRGHLSMWRI.LHLELLVGER.SG
  262-  330 (82.18/61.63)	MDTVIRQvQVLRQGRWKDAIRFElISDGSSgstQLNQDGETDSagLRTP..GLK..IVYW...LDLDKNSGTSdSG
 1540- 1580 (33.99/11.17)	..........................EG.A...LLNLDQEQPA..LRFFvgGYVFAVSVHRVqLLLQVLSVKR...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.42|      15|      18|    1396|    1413|      11
---------------------------------------------------------------------------
 1397- 1412 (24.68/15.26)	GQQTAGlANSNPSNPG
 1414- 1428 (27.74/12.40)	GSQLSG.ANGNRVNLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.83|      17|      18|    1226|    1243|      12
---------------------------------------------------------------------------
 1226- 1243 (27.26/20.88)	AAATRPARAGPAPGvPGV
 1246- 1262 (30.57/18.58)	AIASMPKQAGYVQS.QGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.71|      29|      43|     949|     977|      13
---------------------------------------------------------------------------
  949-  977 (51.88/26.58)	NAPSNIYVSALLHVVRHCS.VCIKHARLTS
  994- 1023 (50.84/25.92)	NASSNIWFRLPFARGDSCQhICLRLGRPGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.29|      19|     261|    1463|    1498|      16
---------------------------------------------------------------------------
 1479- 1498 (35.12/44.83)	GElNTAIIGLGDDGGYGG..GW
 1742- 1762 (36.17/10.65)	GE.NTNVTFLGMEGSHGGraCW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14357 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSLYPSNNVKGPMHSNSYSSLSSGLGRGTTVKKLSASKSDQDLASLRSPHSVEVGSSSSVDEDHLRLLNDTSMDALSGSRSSRLLSPSQSTGSRASTPGGKHSGLRSSPTGPLAGSVRGTGSSSLATTPVSQAAGDTAVFHGSGHNVSKPDKNPRKRTVSDMLNLI
727
892










Molecular Recognition Features






MoRF SequenceStartStop




NANANA