<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14340

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSQINSQTTQATVMATVPLHIEPLQGAQSLVGIKSILDRVLERIHGEFDVLLQHGPSLNDSDRKRNLLLHLHATRQQLMRLLALVQWSPKAKALTECVDQDKVLDQAAGHARLIHAAVDDMCAAHLERLGRFNPMSDVQTALEVLSTGNYRDLPSSIEKLRPEGPIPLSAKRVRLRRITHIIYSQLMKTQLPDRVQVVEVLDGYVILRAPGLYEAKVHRYSSYEAKMTLSPLLEVPDAPSIRGKLKTELPLKHVTDTDVAAQVGHPPASAADNNHDEEEDGVTSGPKPQRWLWVLISFELLPNSLRRKPLGNAQVTHLLENLNMRMSLAADAAAYEKLRRNSYRSATPAAVSVAEDAMDADERVDTAAPSSSAMAAGLSESHALSGHSSRSRSLASSAPATGTSSMMAGAAGCTGQFKANVESMRLHAADESTMPVLVAHSLLSDISMRLLLDAIRAAAEGLLAERWSGDHLEIQPAVTLMPGIRLMYWRQATPLTILLTPDSIPAVVASTVNLGNTQSRYSSQLLSSSLTGGGLHHLEIGIDQSGSPIVTHLPQLQHVNLKHGDKWSGALTSATMHEVQQMGAVSEASQSEPVVVQAPELSLNSAAVNVDELLLLASAHVACLELSILRAGIQACLQKGATASAPLFTLRIAALPLPWIRRQVGDMVRETLTEAAVKAGHSPAAADVGGGFEGAVSTHPHLVDFASASSRGPPPLHPHHFIVECPVLEVHVEDMLLMKVSKNLITGRILLHAGTAVSSDFHISSHQATFKMEEEINKLAADAYREASTLPPSSASSSASITPDSLAEVGAAKAVRVISLYLARIFLEQYRRVGLIRFISMARRLQLHSQGVGKAMMADQIKHFPWLNPSRSSLDWASVPILLPPSYPPLPARHTEPLNHHASTPTGEARGLYWLLSTEHPSGSFSTGTRPSYYLIILSCTLQGEPLQVLKVVSVPPAIYMTSPPGRLPHVSEIEGVKSEHTSFEDQDEDVRNRRGSVLCASELVLGSGDSLASLQELQMQPMSSSLIQHPTTLSGHDWTPVMTSPSPGLPSEPAAGSTIPLSALPLSYPHGQPEGDSSTFIKNGFEGEVKSVIAWCKSHMQWETMLCQFQSLGVRFVESMSGASPNTVVLESLLGDVPLPHVISRACLHSTEDEGAGSTLATSSLSIHFVHVRLDTHSISQQSSFSSVTSTSGSEAHGFIATISGRFLADSSSSSSLITRRGAVGEDQWRSLGSEQTVPCHAHSSGRTWQAELRGAMHCMCTTANMVLAGRDSCLSSSLPPLQLVYSFHHGHSVLDLLQDLASILRMQEMLSELERMGKVSRVLRVVNHGMETIPWSKDAPTLPRTQEDFMDSDVDGSVSLRRVHVAANGLDSFRDTIIKAEEVNVKLEESPCNMLSRKRGREDSWPHENGNGENHHPHHPVVSTEKVKPMLNDTSLEVNMSREKAFSKEPYPHTLFWMWPKNGSVELLHYGYFSAVLQYKPPDDIPTSEHTPLVSSASRALHLFFHWRPATQPKILVPFQEGEAGVSTSSASSCCAVSCCIRATFSANMEACNGLDQQMSALPEVVLSSYQDMADMGEFGLMMDALVITVSPMSQLVASAAKTTQSSSHSSSGYLPQPVLLQSHPPFQHRMLISLPCADSSSPSHSAYITVDLFCTATGQSWLKLCEANCLDNVEGQDYLLRAKREEAGLRAVRKVLAGYPQEYLTLGRARSYETDMSAPLTREWGISSTANRGLWVLVHTQRLQEVLQSVKEVISCLQG
Length1762
PositionTail
OrganismChlamydomonas eustigma
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Chlorophyceae> CS clade> Chlamydomonadales> Chlamydomonadaceae> Chlamydomonas.
Aromaticity0.05
Grand average of hydropathy-0.144
Instability index53.27
Isoelectric point6.16
Molecular weight191391.57
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14340
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     394.34|     113|     161|     791|     911|       1
---------------------------------------------------------------------------
  446-  519 (46.50/17.90)	.................................................ISM..RLLLDAiRAAAEGLLAerwsgDH.LEIQPavT.....LMPGI.RLMYWrqaTPLTILLTP..DSIP....AvvASTVNLGN.TQS........
  791-  911 (181.40/119.21)	PPSSASSSasiTPDSLAEVGAAKAVRviSLYLAriFLEQYRRVGLIR.FISMARRLQLHS.QGVGKAMMA.....DQ.IKHFP..W.....LNPSR.SSLDW...ASVPILLPPSyPPLP....A..RHTEPLNH.HASTPTGEARG
  956- 1076 (166.43/90.86)	PPAIYMTS...PPGRLPHVSEIEGVK..SEHTS..FEDQDEDVRNRRgSVLCASELVL....GSGDSLAS.....LQeLQMQP..MsssliQHPTTlSGHDW...T..PVMTSPS.PGLPsepaA..GSTIPLSAlPLSYPHGQPEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     342.87|     101|     907|     621|     726|       2
---------------------------------------------------------------------------
  104-  185 (90.26/51.93)	...................................LDQAAGHA......RLIHAAVD...DMCAAHLE....RLGRFNP.MSDVQTALE...VLST.GNYRDLPSSIEKlrpeGPIPLSAKRvrlrritHIIYSQ
  195-  288 (84.62/49.16)	VQVVEVldgyVILRApGLyEAKVHRYSSYEA.....KMTLSPLlevpdaPSIRGKLKtelPLKHVTDTDVAAQVGHPPAsAADNNHDEEedGVTS..................GPKP..................
  621-  726 (167.99/120.26)	VACLEL....SILRA.GI.QACLQKGATASAplftLRIAALPL......PWIRRQVG...DMVRETLTEAAVKAGHSPA.AADVGGGFE..GAVSThPHLVDFASASSR....GPPPLHPHH.......FIVECP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.58|      42|      45|    1366|    1409|       3
---------------------------------------------------------------------------
 1368- 1409 (72.28/43.59)	AANGLDSF.RDTIIKAEEVNVKLEESPCNM.LSRKRG.REDSWPH
 1411- 1455 (61.29/30.49)	NGNGENHHpHHPVVSTEKVKPMLNDTSLEVnMSREKAfSKEPYPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.94|      39|      46|    1158|    1198|       4
---------------------------------------------------------------------------
 1158- 1198 (57.38/43.89)	GSTLATSSLSIHFVHvRLDTHSISQQSSFSSvTSTSGSEAH
 1206- 1244 (69.56/44.16)	GRFLADSSSSSSLIT.RRGAVGEDQWRSLGS.EQTVPCHAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.79|      32|     696|     533|     564|       5
---------------------------------------------------------------------------
  533-  564 (58.46/35.60)	GGLHHL....EIGIDQSGSPIVTHLPQLQHV.NLKHG
 1256- 1292 (50.33/29.49)	GAMHCMcttaNMVLAGRDSCLSSSLPPLQLVySFHHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.35|      25|     696|     921|     945|       6
---------------------------------------------------------------------------
  921-  945 (45.27/28.59)	PSGSFSTGTRPSYYLIILSCTLQGE
 1638- 1662 (46.08/29.25)	PCADSSSPSHSAYITVDLFCTATGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.11|      18|    1444|     289|     306|       8
---------------------------------------------------------------------------
  289-  306 (33.80/20.97)	QRWLWVLISFELLPNSLR
 1734- 1751 (32.31/19.71)	NRGLWVLVHTQRLQEVLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14340 with Med14 domain of Kingdom Viridiplantae
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