<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14328

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSTTHISLEPPAITAQDGLDDDLFAKPARLYEVTNEGKQVFTRQVGEDPNKAPTARLLRIWQERGDFSQLTSRSIGDEQHKDKDVATTTTTNDLIRDQDGDEDDVHGLGMTPEQMRELQVTMMQQLELARGELTTALDLLSIIAAPTVATTVDAEALPLPQQTLTIVPSAPPVPLPSSDDDSTNAASLLPLATSLSSLRESANSFFSASNQVLAFISTSTSTSTSTASTSTWTSSSSRNSTSTQWSTLLHLHSSTPFPLIPLGAQPNASFSGQGEHRLAKQVGVFFGCAEAAPAFRRVGVAQVEQVLQEVQERKDGKGKGKGKGKSRGRKLVVEVEMEGKGKDWCVWSGGDKDGKELDVEEVLRQRGRNVFAEELFTVLSNEARSDASVKSRLELGKRSQGDSVVTEGHGWKLKVTMVAVPNPNFEAPTPEPNAIAPLLVPLLRLLLIQEYTRRRSSTSSSASIPVLATLSAFLSHLYRLISLSQDLTALTSTIDPSIPTSTTYHPPLASAPLQAIRKILTPPTAATEIKELGGRIVLRIGSHPTSLFHISHSTLLPQPFSISTNTSSASPSMGVSAFALASHHGLVLQAPRSAPVVVGSVGQLQGFLKEQMGEVLRRYMGRKIQVELERQKNEGIEVDQGS
Length642
PositionHead
OrganismMicrobotryum intermedium
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.05
Grand average of hydropathy-0.283
Instability index43.23
Isoelectric point6.02
Molecular weight69227.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14328
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.36|      16|      25|      14|      30|       1
---------------------------------------------------------------------------
   14-   30 (23.99/15.97)	TAQDGLDDDLfAKPARL
   42-   57 (29.37/15.01)	TRQVGEDPNK.APTARL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.08|      51|      83|     163|     215|       2
---------------------------------------------------------------------------
  163-  213 (82.22/36.30)	TLTIVPSAPPVPLPSSDDDSTNA..ASLLPLATS....LSSLRESANSFFSASNQVL
  221-  271 (56.79/23.78)	STSTSTASTSTWTSSSSRNSTSTqwSTLLHLHSStpfpLIPLGAQPNASFS......
  551-  580 (37.07/13.38)	.....................SH..STLLPQPFS....ISTNTSSASPSMGVSAFAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.75|      44|      72|     296|     341|       3
---------------------------------------------------------------------------
  296-  338 (61.28/37.45)	RRVGVAQVEQVLQEvQERKDGKGKG....K...GKGKSRGRKLVVEVEME..
  339-  366 (22.03/ 8.31)	....................GKGKDwcvwS...G.GDKDGKELDVEEVLRQR
  368-  409 (56.43/34.76)	RNVFAEELFTVLSN.EARSDASVKS....RlelGK.RSQGDSVVT....EGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.38|      15|      15|     506|     520|       5
---------------------------------------------------------------------------
  506-  520 (25.43/14.62)	PPLASAPLQAI..RKIL
  522-  538 (19.96/ 9.98)	PPTAATEIKELggRIVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14328 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QLTSRSIGDEQHKDKDVATTTTTNDLIRDQDGDEDDVHGLGMTPEQMRELQVTMMQ
2) TVDAEALPLPQQTLTIVPSAPPVPLPSSDDDSTNAA
69
151
124
186










Molecular Recognition Features






MoRF SequenceStartStop




1) TARLLRIWQERG
54
65