<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14322

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDPVVLSNGGGPSHHGHGHGHGHGHGHGQGHGQGQGHGPSPTTASSSNPHIHSSSSSSSSWSLSSPAQPRSQPQPPLRVDSLSPSTSTTTTIPTLKLIHAQQHSRAQDDRSLDDELPTVTHDLIPLSHIVQRLVAQVHADLLNLTETQVAHKSHRLRAIVDYVLQTRRQLLKLLVLVRWSSQADALHKCMNIIGFLARQNFEFDHSVQGLHEVKEVLGGARVRNYDLTSALTVLSTGHYPFLPSVIPESFTQPLPLSDSTVLETLTQVDQILAYRLACLEKLPRAMQTYWIKDGRVGFRVERMWEAVFTYGGEQGKEEWYLLGVKFGFNVKDARGGERIRHCASLQRNIVVRLTCPSCSVHLVWSSEPSGPMKETILQLCNQELARHPATDSTSPPKSAHLVRAYNFLQRIALSYQLEAIASQASVLAQTKSIACVRCVRELDGRGLRVDYWLPKEGSSSTSGNAGSGSSAGGGGPRPIPTSTAPCLRFAYGQRDETRGTERIELMRRRALEKLLKSGGKEGKRKKATSAQTTASETRQEESMEEQEDVDDALSITWTVPPSTDAAVPIDTTAVDLTLDDSLDLETLLRRVTTRHVRSNVLELYEQLVNELDPNDLELVSSTNSNGPSIVDRDEEAQDEGVPQIKVHLYSSHYIVVSLSTLSGKLEFKAVGEATSLREARLRGAAEKVDRSRRLLGETLLRVRATTILDEVDTKAGYLGLTTTKRLPLKSNDMARFGSTTRGLLFIQLKGVSNGSNHGSQALAPASSFGWMSSAPSYYLVLVMNESGFRFALIGTREEADQMSAWTTIDEMGWIERGSVAAAGQQEGRTGFDVGIDDLGDLYAYCIKRIKFYIIESQLHLRRIPYQHVAPSVPPSSATASAPAATSLTPTSPYLVIHSSDLISSPTPVAHRNIAIHFLPPRSNSSTGRLGDAQDDQVVFLLKLKATLSPPSQHSYGARTHDDAPSQDLWPPNVLYSPLTNLLEFRFDDLETCVQNFLTAYGLVVKSVVMKRHRLLQIKRQDHAVSLVKAVMEAKVGGGEATTMTTTMTTTMTTTTTAATAGGARNR
Length1066
PositionTail
OrganismMicrobotryum intermedium
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.06
Grand average of hydropathy-0.336
Instability index47.08
Isoelectric point7.49
Molecular weight116622.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14322
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.03|      71|     255|     537|     627|       1
---------------------------------------------------------------------------
  537-  627 (104.07/94.02)	TRQE.ESMEEQEDVDDalsITWTVPPSTDAAVPIDT.TAVDLTLDDSLDLETL...............LRRVTTRHVRSNVlelyeqlvnelDPndlelvSSTNSNGP
  795-  882 (109.96/64.26)	TREEaDQMSAWTTIDE...MGWIERGSVAAAGQQEGrTGFDVGIDDLGDLYAYcikrikfyiiesqlhLRRIPYQHVAPSV...........PP......SSATASAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.15|      21|      22|     182|     203|       2
---------------------------------------------------------------------------
  183-  203 (36.48/31.33)	ADALHKCMNIIGFLARQNFEF
  207-  227 (32.67/20.97)	VQGLHEVKEVLGGARVRNYDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.49|      12|      23|      87|      98|       3
---------------------------------------------------------------------------
   87-   98 (19.99/10.85)	STTTTIPTL..KLI
  111-  124 (15.50/ 6.83)	SLDDELPTVthDLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.39|      45|     842|      40|     109|       4
---------------------------------------------------------------------------
   40-  109 (58.95/64.26)	SPTTASSSNPHIH..SSSSSSSSWSLSSpAQPrSQ.pqpplrvdSLSPststtttiptlklihAQQHS...RAQDD
  904-  962 (66.44/38.04)	SPTPVAHRNIAIHflPPRSNSSTGRLGD.AQD.DQvvfllklkaTLSP...............PSQHSygaRTHDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.64|      15|      18|     275|     289|       5
---------------------------------------------------------------------------
  275-  289 (26.79/14.61)	RLAC.LEKLPRAMQTY
  295-  310 (21.86/10.80)	RVGFrVERMWEAVFTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.09|      35|     725|     235|     274|       6
---------------------------------------------------------------------------
  235-  274 (49.92/41.34)	STGHYPflPSVIPESFTQPLPLS.DStvLETLTQvDQILAY
  965- 1000 (61.17/33.81)	SQDLWP..PNVLYSPLTNLLEFRfDD..LETCVQ.NFLTAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.25|      15|     161|     325|     339|       8
---------------------------------------------------------------------------
  325-  339 (28.08/17.94)	KFGFNVKD.ARGGERI
  488-  503 (24.17/14.40)	RFAYGQRDeTRGTERI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.93|      27|     522|     152|     178|      11
---------------------------------------------------------------------------
  152-  178 (43.56/25.32)	KSHRLRAIVDYVLQTRRQLLKLLVLVR
  677-  703 (43.38/25.18)	REARLRGAAEKVDRSRRLLGETLLRVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14322 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KSGGKEGKRKKATSAQTTASETRQEESMEEQEDVDDALSITWTVPPS
2) LPKEGSSSTSGNAGSGSSAGGGGPRPIPTSTAPCLRFAY
3) MDPVVLSNGGGPSHHGHGHGHGHGHGHGQGHGQGQGHGPSPTTASSSNPHIHSSSSSSSSWSLSSPAQPRSQPQPPLRVDSLSPST
4) TTTTIPTLKLIHAQQHSRAQDDRSLDDELP
516
453
1
88
562
491
86
117










Molecular Recognition Features






MoRF SequenceStartStop




NANANA