<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14317

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAPHPLPARPVQSVAAVSSWPSLAQPPLSTGATMIQHGNLTPAARNQSGTGGSSTTLPSPPTAVPPMPRLPMPPPPPYSGPPASAAQQSQGWAHSQSQGQGPLPLPALGAARSSSFQGNATSPNGSNTPGSLPTSPKWGTPGQQLPQSYQQHHLATPSHTPTPASASMPSSAMPRAPMMRKRLTSKDVRVNSVQVNLPGQGRWKVHWRAWRGPALLDTSVTAPPTPPSSANVSNKSLCSQLGTPLHEHTPMTKYEPLESAAPTPTTTTTALKRARSALGEDDGTTSTPIPSTSSATGTSLRDRLQSLQELDHAKDPIELAVKQVQRVAAALTTPAPGTASSMLPSLFSYVKISAVRPIEDFKGKGKEEATVAHESAVGRMFWVFALSSDSIEHDPTREALSALEFADIIYTGVGKGHFAHRDVFPAMYESTTPTLTDPKTVPSQPTSVALPLAESASAYPSVLSLSSQFHADLPCPANAPQPQTRICSPCEAFLAGVGNAIRRSLVAREDVDSPSELRRQALPLGSAVVILPTASEPFGYSGRRVSAEAIKTTLHLSLNLQGVLVRSAVKDVAYRPYPASSATVTPVPTGSPVLLSPLGTPATFVKRMAISSHSLRSSQVSATLRQNWQNALDGSDLELDRDETWLVCRISTPQHGTVANTSFQAASSSDLLDVMWPASLCILDGTRSQPSRSPESTPPRPKSVDLEDPSSLDPFVPPISEAGLCSPDVLTRRQMASALHRGSAAGAPNAYKTASSRTYHDPIRSRVEQVGTLMVELHAQREQRLRLEREAEAVRASTTAVATTAPPASPAVTEPGKGVSTAGAPINMRTPISLVGSSAEAPSPGDAFSAAERSLMTALGGPSFTTTETATMQVLNASALTTTKNAEMDHLYPSPFEAPNALPIVGEGAGGGSEMKTVGLGSSHDATFPNFDWGEDFSAGQNTGLRHNQDFDDGMMMDLNDDDFSFFDDPAPLPASLPLSTLNGLESAGPSPKFLDHFSHLGSGATPFASVASPASPSFRVASPNVHSSPAVLNFNFESSHNALGLGGTTPRALQLAEQSPFKTPRTPHTPYIEVVDEENDTEIFHGRALATTTVSVAGTPAPNALALKKLTQFEAVPFGSSHATADDRYDPRKGKFGLPSPAWDRDELPKTPNASSSGVPWLTAICNPRANAARQLKRKRTPSLTKKPPRTDGTSNPPARIQLRDRKWIRSTEVDSDHPGEEDSEDDDMNKSDEAPHHAGNNLAATETNPSHRASEHVFGSALLILRDHLNRMLSTAGPKVDSMVPLAVATKAAEIALETTVGLMADQTLHNPDFRSRSTPLKVRSKSSGANASSCATRIVYDRLARVAPNSAPQPLLTLHAPTLLLRAQQTIMQLSTPALDFWNPMGFEPLSGPKDVTAFAVFEEINSDTREAVANWLNDVSEGYQSSRLGRHDLGYIAASGTFSGVENGLAALPSGALSRLRDDYKGMANHLVDAARTRKHVVIYLLDPSEASPTSTAPSIIAALSHILKLRASTMSLVVYPLPLSTVSRWRSIAPADSIAARLRRLAFAVYDTLLVSISSLPAPVPETFPSSQIGRHPVLGPLTRLYQSPAVTASPVRQTSIEFALVWPPSSLEVLHRHRLFHIAYGCFRAPAEGAHGPTHEWIVISGIDEKGETWKSVPQIVRYPPQMQLEEARARQVWKAAKSLHDTADIEWRVVVTKLGNMSKSEILAWDKISREIIVGLRRPLHLTISCSEIGPALSMLPVLHENTEQATSPLSEEGELGVGNGVGTTSSPALGGGDAGRTRNHRKPIHLDSETCLFVHTPNHPITFDASASLVAPASSFLIHVPRLPTFANVPFRPFMPASPAISVLALHVLLSSCTKTSTLRIDLSQHVADIMQSFADLAALGHARWGASGRVPWHLEAVASVLDVLAGLT
Length1921
PositionKinase
OrganismMicrobotryum intermedium
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.05
Grand average of hydropathy-0.269
Instability index54.58
Isoelectric point6.86
Molecular weight204549.22
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14317
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.98|      13|      14|    1354|    1366|       1
---------------------------------------------------------------------------
 1354- 1366 (23.55/12.55)	APQPLLTLHAPTL
 1370- 1382 (22.43/11.55)	AQQTIMQLSTPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     974.89|     144|     147|     567|     710|       2
---------------------------------------------------------------------------
    2-  142 (159.27/47.58)	.............APHP...LPA...RPVqSVAAVSSWPSLA.....QPPLSTGAT.MIQHG....NLTPAA.RNQ..SGTggSSTT....LPSPPTAVP.........PmPRLPMPPP......PPYSGPPASAAQ.Q.SQGWAHS.QSQGQGPLpLPA..LGAARSSSFQGNA.......TSP.ngSNTP.......G........S.LPTSP..K...WGTPG
  203-  340 (146.47/43.17)	WK.......VHWRAWRG....PAlldTSV.TAPPTPPSSANVsnkslCSQLGTPLH.EHTPM....T.KYEP.LES..AAP..TPT.......TTTTALK.........R.ARSALGED......DG....TTSTP......IPSTS..SATGTSL.RDR..L..QSLQELDHAKdpielavKQV...QRVA.......A........AlTTPAP..GTA.....S
  341-  490 (113.57/31.82)	SMlpslfsyVKISAVRPiedFKG...KGK.EEATVAHESAV..........G........RMfwvfALSSDS.IEH..DPT..REAL.........SALEfadiiytgvG.KGHFAHRD......VFPAMYESTTPT.L.TDPKTVPSQPTS.......V..ALP....LAESAS.......AYPsvlSLSS.......QfhadlpcpA.NAPQP..QT.RICSPC
  567-  710 (233.84/73.28)	SA.......VKDVAYRP...YPA...SSA.TVTPVPTGSPVL.....LSPLGTPAT.FVKRM....AISSHS.LRS..SQV..SATL....RQNWQNALD.........G.SDLELDRD......ETWLVCRISTPQ.H.GTVANTSFQAASSSDL.LDV..MWPASLCILDGTR.......SQP...SRSP.......E........S.TPPRP..KSVDLEDPS
  721-  863 (124.22/35.50)	EA....glcSPDVLTRR...QMA...SA......LHRGSAA..........GAPNA.YKTAS....SRTYHDpIRSrvEQV..GTLMvelhAQREQR................LRLEREaeavraSTTAVATTAPPA.S.PAVTEPGKGVSTAGAP.INM..RTPISL..VGSSA.......EAP...SPGD.......A.......fS.AAERS..LMTALGGPS
  885-  996 (126.68/36.34)	NA.......EMDHLY..................PSPFEAPNA.....LPIVGEGAG.GGSEM......KTVG.LGS..SHD..ATFP....NFDWGEDF..................................SAGQ.NtGLRHNQDFDDGMMMDL.ND......DDFSFFDDPA.......PLP...ASLPlstlnglE........S.AGPSP..KFLD.....
  999- 1082 (70.86/17.10)	................................................SHLGSGATpFASVA....SPASPS.FR.........................................................VASPNvH.SSPAVLNFNFESSHNA.LGLggTTPRALQL...AE.......QSP...FKTP.......R..........TPHTPyiEVVDEENDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.79|      34|     144|    1401|    1438|       3
---------------------------------------------------------------------------
 1401- 1438 (55.51/37.86)	AFAVFEEInsdtREAVANWLNDVSEGYQSSRLGRHD.LG
 1551- 1585 (57.28/30.48)	AFAVYDTL....LVSISSLPAPVPETFPSSQIGRHPvLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.75|      63|     306|    1477|    1540|       4
---------------------------------------------------------------------------
 1477- 1540 (101.01/52.04)	DAARTRKHVVIYLLDpSEASPTSTAPSIIAALSHILKLRASTMSLVVYPLPLSTVS..RWRSIAPA
 1785- 1849 (110.74/53.54)	DAGRTRNHRKPIHLD.SETCLFVHTPNHPITFDASASLVAPASSFLIHVPRLPTFAnvPFRPFMPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.72|      11|      16|    1229|    1239|       5
---------------------------------------------------------------------------
 1229- 1239 (21.34/13.86)	DMNKSDEAPHH
 1248- 1258 (20.38/12.80)	ETNPSHRASEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.91|      10|      17|    1119|    1128|       6
---------------------------------------------------------------------------
 1119- 1128 (19.05/ 9.16)	FG.SSHATADD
 1137- 1147 (17.86/ 8.03)	FGlPSPAWDRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.72|      19|      19|    1181|    1199|       7
---------------------------------------------------------------------------
 1181- 1199 (35.28/19.77)	RTPSLTKKPPR.TDGTSNPP
 1201- 1220 (30.45/15.93)	RIQLRDRKWIRsTEVDSDHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14317 with Med13 domain of Kingdom Fungi
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