<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14311

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLLYTVNRKTFGKSSFNQESTHDEHSLCSLSSRNIVAFTATTELNDTNSKTWGCHVYVCDLNMPWHPYKVLTNKGTITALKWDLSGEKLVIADSTGLVQLWTFKDYILNEWMLIGSQYFPGEHILAVAWFHNGKRTSLVPDKKDSTLYNEKFSHLPYAPSVKQFGGRAAQGVFIVSNTGMLGAVMITQDKQNPVCSATESIGNIRQRITAVDISYAKNGQFLVAVSSGSFTLPIRCFRVSIRKTDERCIIASQALPSFFLQDGAPKDDSTNATITHLKFAVSETADSLIVAANNDGNGFIEVWELSEKTHPVHKLFQSKPCGEPFKAVVWQHQALYRCLYSITAIATTKLSIVTPTSYILVTLADSSIHCLSHDGLKEIAISSLNTSWRQDEPLNKCSRPSATISCIDMSWLGCIFLLVDTRGSLYVYKLSPEGSAITLGYACTLLEYCLLTGLDWLDLLLCLRSSMIEALCERFDASFNRQPLPVQQYHYMQFLCIKISLYRMLVSGQSKAADLTSLFMVNSVATAFKSLLRPSDTFHDKVPAERLPSVITDNIITDVDKVLLHIEPKEFTVEPITLQSLQQLIQWVADLALNLLVRLPERRMQMKQPSGYELVQDHKALNMLRELLVIIRIWGLLRPSCLPVFLRSADNIDVLGLLFNLLSKLVQPNAETQQQVDDQLIDDCCLLPNQIMIPQVYQANSITAVATPILFYQSFPLQLEYGSEPDLAFVPELNPVEGCMHNGQIVDAVRHLYLGKQPLLVKQCTRCGAKSQVHNTTRTAAIRAWEQSMGKTKRQVNQVKRAGCRPRRQRIIRPLNLPPEIWQKYLSTKSHKENIQQTNTYTTEMNLPASTASENKLVMKDVKATSSKTSVGATCCNSVGNEPNILKQLSVKIDNSYAVQFNCLFLNENLCKALEIHKSIYDKVMNAKQAFIKFSVQTVIHNKEKGLSDHVILAESELDVSLNLLEKQELLLSNLQKTFREITAPLSVLTCYNIEQDNMLRLSASLSKKENEIDDLKQRNGSLEIKIRNNEQKLLKTKQTYQNIIKTKDKLLSDAKQKCCLMMKRIRLMKESNRRKNINNNMESLRIQKIIHKVVQHATMN
Length1102
PositionTail
OrganismTrichomalopsis sarcophagae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Parasitoida> Chalcidoidea> Pteromalidae> Pteromalinae> Trichomalopsis.
Aromaticity0.07
Grand average of hydropathy-0.164
Instability index47.72
Isoelectric point8.79
Molecular weight124379.47
Publications
PubMed=28648823

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14311
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.54|      18|      27|     581|     600|       1
---------------------------------------------------------------------------
  581-  600 (23.93/22.29)	SLQQLIQwvADLALNLLVRL
  611-  628 (31.61/20.21)	SGYELVQ..DHKALNMLREL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.80|      17|      24|     771|     788|       3
---------------------------------------------------------------------------
  771-  788 (25.32/25.35)	KSQVhNTTRTAAIRAWEQ
  794-  810 (31.47/24.59)	KRQV.NQVKRAGCRPRRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.89|      11|      24|     882|     893|       4
---------------------------------------------------------------------------
  882-  893 (13.75/12.86)	NEpNILKQLSVK
  908-  918 (20.14/12.25)	NE.NLCKALEIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.29|      11|      25|     732|     744|       5
---------------------------------------------------------------------------
  732-  744 (17.98/19.36)	PELnpVEGCMHNG
  759-  769 (22.31/14.29)	PLL..VKQCTRCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.27|      16|      18|     996|    1013|       8
---------------------------------------------------------------------------
  998- 1013 (26.03/18.13)	DNMLRLSASLSKK..ENE
 1015- 1032 (22.24/ 7.92)	DDLKQRNGSLEIKirNNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.86|      11|      25|     919|     929|       9
---------------------------------------------------------------------------
  919-  929 (18.80/13.52)	KSIYDKVMNAK
  946-  956 (18.06/12.68)	KGLSDHVILAE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14311 with Med16 domain of Kingdom Metazoa
Unable to open file!