<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14307

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDNATFAGPRHAPDDHTSSNGDNLRNGSLHINGAAKGAKDHDRDKETYTGKPGTDGHKVLPELAHITQGFFPFSTLVNRSVQQCWNELSDLITELAAIPVSPHSSMPLLPVNGKFPGNQSPENLQKKLRILDFAHAKRAEFIKLLVLSQWSRQARDVSKLIDLQNFIRARHQAFVDALQRVGDMKRDLVQAQVANPDLQTALEILSKGRLESLADLGYKSSKPLTARGALKRLHKINRIISTRLALHDSIPGPFRTYRVHDGRVTFVVRGEFELDLSVGAESELSQFFFVDIRFLYSPSSNIPKGRMSNELDAKVNDKLRDSGLTGCFNFLHGLVLTNKIHILFKQAVELARGLWSEALRVELLHRTLVIQYWALKPGPKSWVEIGIKSGYGNADNQGFGVPCLGLRWMRDGLEVDSRDIQFDTEDLSVECLLRSVIALHISYLLSSAYGILSEYSLFSTGTLSSQAILNVTEPGECQLSVQLTDSRHLRVSIEPMSGAIILSASPCLSERSESDAGLDRSTIDDLVARVSRLRCIAAIEELESNVRILGFETVSPKGLKNDIRKVFPADVLRFSLFWHPSWERNWVVAATSSITGDNWWVVQLRRPSKVATDFSGPGTSVPLCSGHSMSDTFLATNHQTKSPSFPDLGYCLSGMVAVYANVSYLADLQTVEFHPPLRALKVESDLQIPDIFIRYEVSTLPRASQLVLPAGLKRKNVLKNTVRLAFHGIDRRKNIAIFVAYGKLVAPLTDLCTLVRKSDSSLVFKRGGSDFALRLLAPAGRPVIVELFKSLQTLECALSILDFLLQKRLTPQSLSLTHISFAYGPRRDLSATIGIGLSEVISSAELDPVRILARTDPLLFLTLGIRFNHPNPHRRVQGSLAAILNHPSNEAGLDFVTEILSFTLPLMRALEQITSNASRQESFRLQVIVRNAFTFLLHYTYQGFRFQLTTSQHSGQLTWVLRELSSSEARPGHDQLKARLRGTLYHSKGNGWKGLGNGVVADAEGVSNVIWALDGCFTGAQHNTWLPRETKSDDQDHSTQPVSENQNEPVALSQPGMAGDTTMTANFINDKSLQRHTVASNAADVITID
Length1094
PositionTail
OrganismAspergillus turcosus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.149
Instability index42.59
Isoelectric point8.70
Molecular weight121133.81
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14307
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     290.01|      94|     127|     497|     596|       4
---------------------------------------------------------------------------
  497-  596 (142.45/114.28)	SIEPMSGAIILSASPCLSErSESDAGLDRSTIDDLVARVSRLRCIAAIeELESNVRILGFEtvSpkGLK.NDIRKVFPADVL.RFS.LFWHPSWERNWVVAAT
  630-  726 (147.56/97.06)	SGHSMSDTFLATNHQTKSP.SFPDLGYCLSGMVAVYANVSYLADLQTV.EFHPPLRALKVE..S..DLQiPDIFIRYEVSTLpRASqLVLPAGLKRKNVLKNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     267.67|      87|     688|     237|     333|       5
---------------------------------------------------------------------------
  237-  333 (125.27/118.25)	RLHKINRIISTRLaLHDSIPGpFR...TYRVHDGRVTFVVRgefELDlSVGAESELSQfFFVDIR.FLYSPSSNIPKGrMSNEL..DAK.VNDKLRdsGLTGCF
  929- 1022 (142.41/93.55)	RLQVIVRNAFTFL.LHYTYQG.FRfqlTTSQHSGQLTWVLR...ELS.SSEARPGHDQ.LKARLRgTLYHSKGNGWKG.LGNGVvaDAEgVSNVIW..ALDGCF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.19|      10|      95|      95|     104|       8
---------------------------------------------------------------------------
   95-  104 (17.02/10.87)	DLITELAAIP
  192-  201 (17.18/11.04)	DLVQAQVANP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14307 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TWLPRETKSDDQDHSTQPVSENQNEPVALSQPGMAGDTTMTANFINDKSL
2) VIMDNATFAGPRHAPDDHTSSNGDNLRNGSLHINGAAKGAKDHDRDKETYTGKPGTDGHKV
1029
4
1078
64










Molecular Recognition Features






MoRF SequenceStartStop




NANANA