<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14304

Description Uncharacterized protein
SequenceMDQQPPVQPQQRPPPSLTNPRFTLELEFVSSLANPYYLSHLAVTYPNLLGISKSGDDGDTGTEASDRDAQAFAAYLAYLYSYWKTPEYAQFLTHPGATLRALRLLQEEAFRRDVIRPQVIEALAGTGLEDGQGGSNPEAENTGHNEGDQGTQKGVLDVKPNSSELSYLLYYVSTRRSKLTKVGAFLEKRAARDVWRNKLGNVQVTLQILTALIEKVPRDLPIYARSVMTVLETVLRSGDVSMVEESISTFETFCRHQDMAALSAEQDFASQYREVVRTYADFADQAESVAQLKTAPSGPMVTRWRTAGLRAIKGVVGSEAGFAADGGDSLRILLPVILERLYNGDNSLLVSLELRLHESEKNDPALRPRRRVSTATVQTVDAVDGDPALASQSAADVDRQAEMDMRLLALRCLERIVVTGSSRGQIRVTTKAVLEFILNKGLLTYDGNRPVDTDSMGGWATSLVELMAKWCPVQVRFIILIAAMEMLLEVQPTEETLQRSYALIYVIDWLLKSPVNMIGLSVIDILLGLMQFMSTLLSHPAGAKSAEEGLDEKLNDHDVVLSAKEVGLLALLQRTIGDLTTHIYYGDQVSDMVRTILTRMKPSIDNKLSPATALPNPPDNTESNSNSAGFPGEMNAAAFSLPIAKVTALKAIKDILSVAKSNRHTAAGVENRNPVGIHAWEGTQWLLREPDRDTRHAYIDAFLTWLRFETTQDDTRARCGPVKGTGSLPRLEFPEVTEKADKRPLNVSQREKVIIAAQLNFLRLFHLTIYDIALDCPTDESEILLLHLLLTSLVERLGVNAVRFGLPMVLKLQEDLEAAQSLRFPAAKVNVGSLVHGYLWAICEKFELESYRVGNEIKIEIDRRKQNGVWLDRVRMPAIRIDGIIESSEKSPGNGGVTAQSQLIPFKAGIEELVNRIEEAYNSSMTSPAHSPSASPGRNYALPVLGHGAATASSLKCNLPSSIKEQMLSPWSREACLAAAEKEKAEAMSINGSRHGTLGLRNYATLNGAGNSSHSIATSAHQSAIGAAAGLQHLRRMSAESPGTPVNGSGRESPVRVTELRRVLSVNVEGNARRLSPLRGRLDASSGSVVSSSSESMVSGFSLSEYDADGNSIRPQSIRDGRLSANGDGMETPKASSMAVNGGGSRQSSLSYNLRSDGIPPVPPIPPSISIPGGFSNDSRRSLSNPERPSTAPGPHQVFPSGKQGAFSADNERTLSRHKSRSSTNLAGAADSNKPSYLTDGGPPDAALRRDVQNLINGFLSPMDADLRHGGPNAPGRRARNSHAGRRSATGGIGRPPY
Length1298
PositionMiddle
OrganismAspergillus turcosus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.306
Instability index52.48
Isoelectric point6.60
Molecular weight140986.75
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
protein localization to plasma membrane	GO:0072659	IEA:InterPro
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14304
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.70|      13|      33|     880|     892|       1
---------------------------------------------------------------------------
  880-  892 (22.87/12.06)	RIDGIIESSEKSP
  916-  928 (23.82/12.83)	RIEEAYNSSMTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.62|      21|      46|     973|     997|       2
---------------------------------------------------------------------------
  973-  993 (31.92/11.93)	REACLAAAEKEKAEAMSINGS
 1022- 1042 (31.70/12.42)	QSAIGAAAGLQHLRRMSAESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     216.63|      70|     246|     832|     969|       3
---------------------------------------------------------------------------
  832-  915 (114.03/63.51)	GSLVHGYLWAICEKFELESYRV.GNEIK...IEIDRRKQNGVWLDRVRMPAIridgiiessekspgNGGVTAQSQL........IPFKAGIEELVN
 1087- 1170 (102.60/22.22)	GSVVSSSSESMVSGFSLSEYDAdGNSIRpqsIRDGRLSANGDGMETPKASSM............avNGGGSRQSSLsynlrsdgIPPVPPIPPSIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.46|      28|     247|     932|     969|       4
---------------------------------------------------------------------------
  932-  969 (42.76/39.30)	PSASPGRNYALPVLGHGAATASslkcnlpssiKEQMLS
 1189- 1216 (52.70/27.93)	PSTAPGPHQVFPSGKQGAFSAD..........NERTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.62|      20|     246|     520|     539|       7
---------------------------------------------------------------------------
  520-  539 (34.13/24.54)	LSVIDI.LLGLMQ.FMSTLLSH
  561-  582 (23.49/14.49)	LSAKEVgLLALLQrTIGDLTTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.64|      47|      88|      55|     103|       9
---------------------------------------------------------------------------
   55-  103 (81.66/66.43)	G.DDGDTGTEASDRDAQAFAAYLAYLYSYWKTPEYAqfLTHPGATL..RALR
  143-  192 (72.97/51.79)	GhNEGDQGTQKGVLDVKPNSSELSYLLYYVSTRRSK..LTKVGAFLekRAAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.30|      25|      27|    1225|    1250|      10
---------------------------------------------------------------------------
 1225- 1250 (40.29/29.69)	NLAGAADSNKPSYLTDGGPpDAALRR
 1254- 1278 (48.01/30.26)	NLINGFLSPMDADLRHGGP.NAPGRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14304 with Med31 domain of Kingdom Fungi
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