<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14295

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLESNQLVPAGGGPASAPAPPAPGAVTAAASPGYRLSTLIDFLLHRTYAELTVLADLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGVDQATLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANHGSHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYYFLSVSYAEGDDNPATALLLQQFKPNIEELVLDTKSGKQMKSGVKRKLSGDPCSIEPKKPKRTGEMCAFNKVLAHIVAMCDTNMPFIGLRLELSNMDIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPTHLNIFSEVRIYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVLLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTLDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPIPDVSHSPRAGTSSQAMPTSMPPPRKLPQRSWAASIPTILTHSALNVLLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVSQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPGECTIFAAVRDLMLNLTLPPGGRP
Length1410
PositionTail
OrganismColinus virginianus (Northern bobwhite) (Tetrao virginianus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Odontophoridae> Colinus.
Aromaticity0.06
Grand average of hydropathy-0.177
Instability index52.81
Isoelectric point8.84
Molecular weight155858.33
Publications
PubMed=24621616

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP14295
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     198.53|      30|      32|     990|    1019|       1
---------------------------------------------------------------------------
  955-  982 (41.61/20.75)	.PQQP.....PQQ.PQQPFAKQAGASG.....AYPL..TSP.P
  990- 1019 (58.46/33.01)	TPSPS.....MMH.TQSPGNLHAASSP.....SGAL..RAPSP
 1025- 1053 (36.48/17.02)	TPSPSslgitM.......GQTANFASP.....HGTL..DPSSP
 1056- 1077 (25.53/ 9.05)	..........MMSpSQRAGNWPGSPQV.....SG......PSP
 1085- 1118 (36.45/16.99)	SPANP.....SLH.SPIPDVSH...SPragtsSQAMptSMPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.68|      60|     473|     817|     911|       2
---------------------------------------------------------------------------
  724-  796 (85.53/69.83)	NSIARL...............YECvleFArSLPDIPTHLNIfsevriyNYRKLiLC...YGTTKG.SSISIQWNSILQKFHISLGTVgPNSG
  833-  911 (94.15/98.45)	NAINKLptvpmlgltqrtntaYQC...FS.ILPQSPTHIRL.......AFRNM.YCidiYCRSRGvVAIRDGAYSLFDNSKIVEGFY.PAPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     248.26|      64|     147|     218|     296|       3
---------------------------------------------------------------------------
  218-  281 (108.26/65.58)	EFEATLTV..MGDDPD..IPWRLLKLEILVEDKETGDSFCLALQLEVLHSQ..TLMLIRERWGDLVQVER
  368-  433 (93.14/54.24)	ELKAILKSynVNDNSF..IETALPTLVIPILE.PCGRSECLHVFVD.LHSGmfQLMLYGVDQATLDDIEK
  435-  475 (46.86/22.52)	..........VNDDMKriIPW.LQQLKFWLGQQRCKQSI...KHLPTVSSE..TLQL.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     279.61|      66|     477|     138|     208|       4
---------------------------------------------------------------------------
  143-  208 (112.18/74.32)	IPY.AIDVLTTGSYPRLPTCIRDKIIPPDPIT...KSEKQT.TLHQLNQILRH..RLVTTDLPPQLANLTVAN
  552-  616 (73.24/40.24)	.......VLDTKSGKQMKSGVKRK.LSGDPCSiepKKPKRTgEMCAFNKVLAHivAMCDTNMPFIGLRLELSN
  619-  681 (94.20/51.67)	IPHqGVQVEGDG.FSH...AIRLLKIPPCKGV...NEETQK.ALDRSLLDCTF..RLQGRNNRTWVAELVFAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.49|      97|    1282|      23|     139|       8
---------------------------------------------------------------------------
   23-  139 (137.61/161.39)	APPAPGAVTAAASPGYRLStlidfLLHRTYAELTVLADLLPRKTDMerkieivqfASRTRQlfvrlLALVKWANNAgKVEKCAMISSFLDQQAILFVDTADRLASLA..RDALVHARLP
 1307- 1405 (160.88/129.63)	APPGTPAVVLKSKMLFFLQ.....LTQKTTVSQEAVSIIVPIIYDM.........ASGTTQ.....QADIPRQQNS.SVAAPMMVSNILKRFAELNSPRPGECTIFAavRDLMLNLTLP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14295 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTLDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPIPDVSHSPRAGTSSQAMPTSMPPPRKLPQRSWA
923
1127










Molecular Recognition Features






MoRF SequenceStartStop




NANANA