<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14290

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRELWIFWWGDDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKRKQVDYEQKLEDKLLVLGRDICLHLKVCFFSLPSEHLSCSFTFFLHGDSNVCTSVEISQHQPVYLLSEEHLTLAQQSNSPFQVILSPFGLNGTLTGQSFKLSDSSTKKLIGEWKQFYPVTSNLKEGSEEKQEDMDWEDDSLAAVEVLVAGVRMVYPACFVLVPQTDIPAPSTVGTSHCSATCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQKWVKFSSVSDGFISDSTSHHGGKIPRKLANQVVDRVWQECNMNRTQNKRKYSATSNSLCDEETADKVASWDFVEATQRTNCNCSRHKNLKPRNSGQQGQAPPVGQQQQAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLVMTAPDSQVRFSNIRTNDVAKTPQMHNAEMHNAEMANSPQPPPLSPHPCDVVDEGVTKAPSTPQSQHFYQMPTPDPLVPTKTMEDRLDGLSQPFPAQFPEVIEPTMYIGTAVNLEEDEADTTWKYYKVPKKKDVEFLPPQLPNDKLRDDPVIPAGQENITSVTELMVQCRKPLKVSDELVQQYQSKNQYLAAVVSEADQEPEIDPYAFVDGDVEFLFPDSKKDRQNIERETGKKHKAEDGTSGVTVLSHEGEDAMSLFSPSVKQDAQRIAAHARTASTSLIHETDLVVSYTDLDNLFNSDEDELAPGSKRTVNGADDKSNCKEAKAGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTLGGTVLEGNSSSMGAQFRIEVDEGFCSPKPAEIKDYSYVYKPENCQALVGCSMFAPLKTLPSQCLPPIKLPEECIYRQSWTVGKLDLLPPGPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPGSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNSSGLFLEDELDILGRNTECGKEAEKRFEALRATSVEHGSGGLKEPEKLPDELILLLQDQCTNLFSPFGAADQDPIPKVGAVSNLVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKTTCLHHWSKRNVVDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDVAYVVVCPENEALLNGAKSFFRDLTAIYESCRLGQHRPICKLLPDGIMRVGPTASKKLSEKLVTEWFSQTANANNEAFSKLKLYAQVCRYELGPYLASQPLDNSLLAQTNLVPPSSQPASALPPVTASTGNPNTPSAPVASTSSTMTATSNSAMSSAATTANSTLTTTATSSSSANIGSGIPTNKPSSFPPFSSMNNTTSASLPSQAATVQNGQTGGQQQQPVLQTAGMSGDAATAPAQPHPEVSESTMDRDKVGVPTDGDSHAITYPPAIVVYIIDPFTYEKKDESSSSSSLWTLGLLRCFLEMVQVLPPNVKNIISVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPSSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDLYGEQLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASSTYTTENLDLAFNTNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDMGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length2194
PositionMiddle
OrganismColinus virginianus (Northern bobwhite) (Tetrao virginianus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Odontophoridae> Colinus.
Aromaticity0.07
Grand average of hydropathy-0.409
Instability index51.20
Isoelectric point5.45
Molecular weight241673.27
Publications
PubMed=24621616

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14290
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     268.66|      53|      67|     465|     517|       1
---------------------------------------------------------------------------
  465-  517 (91.65/50.01)	PKHKTNEKQDK..GDK.PQKRPLT.P..FHHRVSIS....DDVAMEADSA..SQRLV.MTAPDSQV
  531-  586 (75.62/39.81)	PQMHNAEMHNAemANS.PQPPPLS.P....HPCDVV....DEGVTKAPSTpqSQHFYqMPTPDPLV
  588-  627 (29.29/10.36)	....TKTMEDR..LDGlSQPFPAQfPevIEPTMYIG....TAVNLEEDEA................
 1610- 1660 (72.10/37.58)	PVLQTAGM..S..GDA.ATA.PAQ.P...HPEVSEStmdrDKVGVPTDGD..SH..A.ITYPPAIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     243.21|      62|      71|     942|    1010|       2
---------------------------------------------------------------------------
  909-  949 (48.16/15.95)	.....................PKPAE..IKD..........YSYVYKPencQALVGC.SMfAPLKTLPSQCLPPI
  950- 1018 (115.40/61.82)	KLPEECIYRQSWTvgkldllPPGPAMPFIKDGDGSTMDQE.YGPAYTP...QTHTPF.GM.PPGSAPPSNGGAGI
 1026- 1081 (79.65/33.67)	RFPTPRTPRTPRT.......PRGAGGPASAQGSVKYENSDlYSPASTP...STCRPLnSV.EPATVP........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.60|       9|      71|    1137|    1153|       3
---------------------------------------------------------------------------
 1114- 1122 (20.52/ 8.17)	CVCN....MNIK.G
 1140- 1153 (11.08/15.86)	CTCGfsavMNRKfG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.47|      18|      20|    1486|    1503|       4
---------------------------------------------------------------------------
 1486- 1503 (32.43/18.23)	SQPLDN..SLLAQT.NLVPPS
 1504- 1524 (24.03/11.31)	SQPASAlpPVTASTgNPNTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.62|      13|      78|     641|     653|       6
---------------------------------------------------------------------------
  641-  653 (25.87/13.90)	DVEFLPPQLPNDK
  720-  732 (24.76/12.96)	DVEFLFPDSKKDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.78|      15|      20|    1333|    1352|       7
---------------------------------------------------------------------------
 1333- 1352 (21.23/23.57)	FhkMAGrgsYGTD...ESPEPLP
 1356- 1373 (23.55/ 9.99)	F..LLG...YDYDflvLSPFALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.18|      16|     116|    1577|    1594|      10
---------------------------------------------------------------------------
 1555- 1570 (23.32/ 7.13)	TTATSSSSANIGSGIP
 1577- 1592 (28.86/18.81)	FPPFSSMNNTTSASLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14290 with Med13 domain of Kingdom Metazoa
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