<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14286

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNSVFYSLVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFIRPYDKDEKPVNKSRICLKYVSERLLKNANLAYLSSQLPKGDDVDPFHFLFIYLLAKPSVHYWTDEPTVPRYLGMHGEQLHSRDPLFDQSECHRDSGFSIYVFLNCEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPSPFQVLVSPYGLNGTLTGQSYKMSDPATRKLMEEWQYFYPMVLKKKEGMKEEEELGYDNDFPVAVEVIVGGVRMVYPSAFVLISQSDIPMSQNVASTGGHINVGQQGLGSVKDPSSTCGMPLTPPTSPEQAVMGESGCSQSSISHSAVQEGTVSVHSPKKSSKITPKFHNHMVHRVWKECILNRSQSKHKVFKQRCAAGSSRPPTINQPGFSVGASSSSALPPPASSKHKATERQDKGEKLQKRPMMPFHHRPSVTEELCVEQDTSGQKLGLAGMEPSLEVPNSRKYEKPLSIPARNPSKQMNMNPMDSPHSPSSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGSGLELQPLPSLDERTVLVGQRLPLMAEVSETALYCGIIQNNESLDMWRTYSVPSSDDLEFRPPDLPCERYDAKMEGNSDSTALKRLLAQPNKRFKILEEQKPVQTLSYLDPLPLIQQPGEGLGDASDPYTFEDGDIKYSFTGNKKCKLVAEKDLLKKNKLEDGIGTKEIPATGHSTPVPDGKDAMSIFSSAPKTDTRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPNSISPEKWEEKDENFLCGTNQSDNELRLSTVADLQRMFPTPPSLEQHPAFSPVMSYKDGISSETVTTLGMMESPMVSMVPTQLAEFKMEVEDGLGSPKPEEIKCVTPAHMHQWGKQAPKPIADHFENMPSWAVPPKIEQLPLPPATFIRDGYNNVPSVGSLADQDYLQMNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQPIPEAHSLYVTLILSDSVLNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFIEDELDIFGKTSDIGQAAERRLMICQSNLISQMGEGARRTQEPPMSLLLLLQNQHTQPFTSLSCLDYMSSNNRQTLPCVNWSYDRLQADSNDSWIECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLDGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWGTEECDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLLPPKYQTPAPASQTQTIPGNTGPVSSNSTCLSTSGAPPTGSSFNSTPNSGTTSLPAGSSSSSGSSVPQLSASSATPSVNQISAAPTPGFSGNIGSGQNTSTGGNTADRSQGSTGPGGDTEAGQNLAQQQQEGQEGVTERERIGIPTEPESADSNAYPPAVVIYMVDPFTYTADEESASTNFWLLSLMRCYTEMLDNLPENMRNSFILQIVPCQYMLQTMKDEQVFYIQHLKSLAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIDLPNRSRRTKLSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKEVCRMCGISSADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPTNDDMFDLPFPDDMDNDIRILITGNLHSSPNSSPVPSPGSPSGIGVGSHYQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISIAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNIL
Length2188
PositionMiddle
OrganismColinus virginianus (Northern bobwhite) (Tetrao virginianus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Odontophoridae> Colinus.
Aromaticity0.07
Grand average of hydropathy-0.415
Instability index58.68
Isoelectric point5.57
Molecular weight240926.65
Publications
PubMed=24621616

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP14286
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     320.24|      66|     100|     755|     820|       1
---------------------------------------------------------------------------
  462-  523 (37.58/13.85)	.............................................EQDTSGqklglaGM.EPSL........EVPN..SRKYEKPlsiparnpskqmnmnpmdSPHSP..SSPLPP..T.LSP
  755-  820 (108.99/55.19)	SLTQVTDL................APSLHDLDNIFDN.......SDEDELG......AV.SPALRS.....SKMPA..VGSEERP..................VGKDGRTAVPYPP..NSISP
  842-  922 (80.68/38.80)	RLSTVADLqrmfptppsleqhpafSPVMSYKDGI.SS.......ETVTTLG......MMeSPMV.......SMVPT..QLAEFKM..................EVEDG.LGSPKPEeiKCVTP
  951- 1028 (92.99/45.93)	KIEQL.PL................PPATFIRDG.YNNvpsvgslADQDYLQ......MN.TPQMNTpvtlnSTAPAsnSGAGVLP..................SPATPRFSVPTPR..TPRTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.85|      16|      16|    1523|    1538|       2
---------------------------------------------------------------------------
 1523- 1538 (30.74/15.96)	NSTCLSTSGAPPTGSS
 1540- 1555 (29.10/14.59)	NSTPNSGTTSLPAGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.73|      17|      17|    1590|    1606|       3
---------------------------------------------------------------------------
 1590- 1606 (30.94/18.63)	GSGQNTSTGGNTADRSQ
 1610- 1626 (31.78/19.36)	GPGGDTEAGQNLAQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     461.02|     173|     632|    1287|    1512|       4
---------------------------------------------------------------------------
  136-  261 (197.41/117.57)	LFDQSECHRDSGFSIYVFLNCEHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHI.HMAQSSPSPF.QVLVS.....PYGLNG.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tLTGQSYkMSDPATRK...............LmeEWQYFYPMVLKKKEGMKEEEE........lGYDNDF
  362-  435 (48.09/ 9.03)	..................................................................SKITPKFHNHMVHRVW..KECilnRSQSKHKVFKQRCAagSSRPPTINqpgfSVGASSSSALPPPASSKHKATERQ.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1300- 1365 ( 6.30/70.98)	..............................................................................................................................................dkgeklqkrpmmpfhhrpsvteelcveqdtsgqklglagmepslevpnsrkyekplsiparnpskqmnmnpmdsphspssplpptlspqprgqeaenldppsvpvnpalygsglelqplpsldertvlvgqrlplmaevsetalycgiiqnnesldmwrtysvpssddlefrppdlpcerydakmegnsdstalkrllaqpnkrfkileeqkpvqtlsyldplpliqqpgeglgdasdpytfedgdikysftgnkkcklvaekdllkknkledgigtkeipatghstpvpdgkdamsifssapktdtrqdnaagragsgsltqvtdlapslhdldnifdnsdedelgavspalrsskmpavgseerpvgkdgrtavpyppnsispekweekdenflcgtnqsdnelrlstvadlqrmfptppsleqhpafspvmsykdgissetvttlgmmespmvsmvptqlaefkmevedglgspkpeeikcvtpahmhqwgkqapkpiadhfenmpswavppkieqlplppatfirdgynnvpsvgsladqdylqmntpqmntpvtlnstapasnsgagvlpspatprfsvptprtprtprtprgggtasgqgsvkydstdqgspastpsttrplnsvepatvqpipeahslyvtlilsdsvlnifkdrnfdsccicacnmnikgadvglyipdssnedqyrctcgfsaimnrklgynsglfiedeldifgktsdigqaaerrlmicqsnlisqmgegarrtqeppmslllllqnqhtqpftslscldymssnnrqtlpcvnwsydrlqadsndswiecfnaleqgrqyvdnptggkvdealvrsatvhswphsnvldismlssqdvvrmlLSLQPF.LQDAIQKKrtgrtweniqhvqgpL..TWQQFHKMAGRGTYGSEESPEplpiptllvGYDKDF
 1380- 1511 (209.22/128.14)	LLDPYGGHRDVAYIVVCPENEALLDGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGImRVGKTVAQKLTDELVSEWFNQPWGTEEC...DNHSRLKLYAQVCR..HHLAPYLA....TLQLDSSLLLPPKYQTPAPASQTQ.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.32|      51|     426|    1691|    1751|       5
---------------------------------------------------------------------------
 1693- 1751 (77.93/86.91)	LPenMRNSfilQIVPCQYMLQTMKDEQVFYIQHLKSLAFsVYC....QCRRP.LPtqIHIKSLT
 2123- 2178 (82.40/55.44)	LP..ARNS...QRVPHPLDSKTTSDVLRFVLEQYNALSW.LTCnpatQDRSScLP..VHFVVLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     368.53|     131|     517|     525|     674|       6
---------------------------------------------------------------------------
  316-  355 (19.83/ 6.51)	STCGMPLTPPTSPEQAVMGESGCSQSSIshSAVQEGTVSV...........................................................................................................................
  527-  666 (205.31/123.04)	GQEAENLDPPSVPVNPALYGSGLELQPL..PSLDERTVLVgQRLPlmaEVSetALYCGIIQNNESLDMWRTYSVPS....SDDLEFRPPDLPCERYDAKMEGNSD.....STALKRLLAQPNKRFkiLEE............QKPVQTLsYLDPLPLIQQPGE
 1061- 1185 (143.40/67.58)	.........................RPL..NSVEPATV...QPIP...EAH..SLYVTLILSDSVLNIFKDRNFDSccicACNMNIKGADVGLYIPDSSNEDQYRctcgfSAIMNRKLGYNSGLF..IEDeldifgktsdigQAAERRL.MICQSNLISQMGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.68|      56|    1122|     668|     728|       7
---------------------------------------------------------------------------
  668-  728 (87.03/68.13)	LGDASDPYT..FedgdIKYSFTGNKKCKLVAEKDlLKKNKLEDGIGTKEIPATGHSTPVPDGK
 1795- 1852 (94.65/59.73)	FGEASQKYNvlF....VGYCLSHDQRWLLASCTD.LHGELLETCIVNIDLPNRSRRTKLSARK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14286 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FKMEVEDGLGSPKPEEIKCVTPAHMHQWGKQAPKPIADHFENMPS
2) KDPSSTCGMPLTPPTSPEQAVMGESGCSQSSISHSAVQEGTVSVHSPKKSSKITPKF
3) KLEDGIGTKEIPATGHSTPVPDGKDAMSIFSSAPKTDTRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPNSISPEKWEEKDENFLCGTNQSDN
4) LRLSTVADLQRMFPTPPSLEQHPAFSPVMSY
5) NLHSSPNSSPVPSPGSPSGIGVGSHYQHSRSQGERLLSREAPE
6) PPKYQTPAPASQTQTIPGNTGPVSSNSTCLSTSGAPPTGSSFNSTPNSGTTSLPAGSSSSSGSSVPQLSASSATPSVNQISAAPTPGFSGNIGSGQNTSTGGNTADRSQGSTGPGGDTEAGQNLAQQQQEGQEGVTERERIGIPTEPESA
7) VFKQRCAAGSSRPPTINQPGFSVGASSSSALPPPASSKHKATERQDKGEKLQKRPMMPFHHRPSVTEELCVEQDTSGQKLGLAGMEPSLEVPNSRKYEKPLSIPARNPSKQMNMNPMDSPHSPSSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGSGLELQ
8) VGSLADQDYLQMNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQ
901
312
705
841
2024
1498
391
973
945
368
839
871
2066
1647
552
1072










Molecular Recognition Features






MoRF SequenceStartStop




NANANA