<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14266

Description Mediator of RNA polymerase II transcription subunit 8 (Fragment)
SequenceREEKQLELTLEALISQVADLKNSLVSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLLRNQVIIPLVLSPDRDEEIMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLITDAARISPDGAQKQIQSLNKMCSNLLEKISKEERESESGGLRQNKQTFNPTDTNALVAAVAFGKGLSNRRPPGSGGSVQSGQPGAGAIIAGASGMQQVPMSSAPAQQQPMLAGVQMAQAGQPGKYIAYLIVIIKQEAR
Length261
PositionHead
OrganismCallipepla squamata (Scaled quail)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Odontophoridae> Callipepla.
Aromaticity0.04
Grand average of hydropathy-0.426
Instability index49.40
Isoelectric point6.04
Molecular weight28601.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364144

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14266
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.42|      26|      28|     120|     147|       1
---------------------------------------------------------------------------
  120-  147 (40.27/29.89)	KqlITDAARISPDGAQKQ.IQSLNKMCSN
  151-  177 (40.16/23.78)	K..ISKEERESESGGLRQnKQTFNPTDTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.75|      12|      29|      75|      86|       2
---------------------------------------------------------------------------
   75-   86 (22.01/15.37)	IP..LVLSPDRD.EE
  103-  117 (13.74/ 6.88)	VPdhLRTKPDPEvEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.27|      25|      36|     183|     207|       3
---------------------------------------------------------------------------
  183-  207 (46.03/26.14)	VAFGKGLSNRRPPGSGGSV.QSGQPG
  221-  246 (42.24/23.45)	VPMSSAPAQQQPMLAGVQMaQAGQPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14266 with Med8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVAFGKGLSNRRPPGSGGSVQSGQPGAGAIIAGASGMQQVPMSSAPAQQQPMLAGV
2) FSHEVVPDHLRTKPDPEVEEQEKQLITDAARISPDGAQKQ
182
98
237
137










Molecular Recognition Features






MoRF SequenceStartStop




1) IVIIK
253
257