<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14264

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLESNQLVPAGGGPASAPAPPAPGAVTAAASPGYRLSTLIDFLLHRTYAELTVLADLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGVDQATLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANHGSHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYYFLSVSYAEGDDNPATALLLQQFKPNIEELVLDTKSGKQMKSGVKRKLSGDPCSIEPKKPKRTGEMCAFNKVLAHIVAMCDTNMPFIGLRLELSNMDIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPTHLNIFSEVRIYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVLLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTLDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPIPDVSHSPRAGTSSQAMPTSMPPPRKLPQRSWAASIPTILTHSALNVLLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFIERYIVVALGKESMNELQLTQKTTVSQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPGECTIFAAVRDLMLNLTLPPGGRP
Length1426
PositionTail
OrganismCallipepla squamata (Scaled quail)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Odontophoridae> Callipepla.
Aromaticity0.06
Grand average of hydropathy-0.175
Instability index52.60
Isoelectric point8.80
Molecular weight157691.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14264
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     222.27|      33|      33|     990|    1022|       1
---------------------------------------------------------------------------
  921-  951 (32.94/12.10)	DSNQ.....DARRRSVNEDDNPPSPIGGDMMDSLIS......
  955-  990 (41.33/17.20)	PQQP.....PQQPQQPFAKQAGASGAYPLTSP.PTSYhntvT
  991- 1025 (55.74/25.97)	PSPS.....MMHTQSPGNLHAASSPSGALRAPSPASF..gpT
 1026- 1053 (27.01/ 8.49)	PSPSslgitM......GQTANFASPHGTLDPSSP........
 1086- 1115 (31.16/11.01)	PANP.....SLHSPIPDVSH...SP....RAGTSSQAmptsM
 1116- 1144 (34.09/12.79)	PPPR.....KL....PQRSWAASIPTILTHSALNVLL....L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.68|      38|      47|     694|     740|       3
---------------------------------------------------------------------------
  694-  740 (53.81/66.98)	PTrHVYLTYE......NQLSEPVGGRKVVEMFLnDWNSIarlyecvLE.FARSL
  744-  788 (58.87/42.57)	PT.HLNIFSEvriynyRKLILCYGTTKGSSISI.QWNSI.......LQkFHISL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.53|      13|    1279|      18|      30|       8
---------------------------------------------------------------------------
   18-   30 (27.49/11.63)	PASAP..APPAPGAV
 1300- 1314 (24.04/ 9.22)	PPSAPpiAPPGTPAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.50|      47|    1053|     156|     207|      11
---------------------------------------------------------------------------
  156-  207 (71.33/58.24)	PRLPTCIRDKIIPPDpiTKSEKQTTLHQLNQILRHRLVTtdlPPQLANLTVA
 1212- 1258 (80.17/50.47)	PKTNQTLQLKVTPEN..TGQWKSEELQVLEKFFETRVAG...PPFKANTLIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.45|      62|     493|     844|     911|      13
---------------------------------------------------------------------------
  844-  911 (102.11/84.10)	LGLTQRTNTAYQCFSILpqSPTHIRLAFRNMYCIDIYCRSRGVVAirdgAYSLFDN..SKIVEGFYPAPG
 1340- 1403 (101.34/66.81)	LQLTQKTTVSQEAVSII..VPIIYDMASGTTQQADIPRQQNSSVA....APMMVSNilKRFAELNSPRPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14264 with Med14 domain of Kingdom Metazoa
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