<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14258

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNKQLRYLSGYLRGYLSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPSPFQVLVSPYGLNGTLTGQSYKMSDPATRKLMEEWQYFYPMVLKKKEGMKEEEELGYDNDFPVAVEVIVGGVRMVYPSAFVLISQSDIPMSQNVASTGGHINVGQQGLGSVKDPSSTCGMPLTPPTSPEQAVMGESGCSQSSISHSAVQEGTVSVHSPKKSSKITPKFHNHMVHRVWKECILNRSQSKHKVFKQRCAAGSSRPPTINQPGFSVGASSSSALPPPASSKHKATERQDKGEKLQKRPMMPFHHRPSVTEELCVEQDTSGQKLGLAGMEPSLEVPNSRKYEKPLSIPARNPSKQMNMNPMDSPHSPSSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGSGLELQPLPSLDERTLLVGQRLPLMAEVSETALYCGIIQNNESLDMWRTYSVPSSDDLEFRPPDLPCERYDAKMEGNSDSTALKRLLAQPNKRFKILEEQKPVQTLSYLDPLPLIQQPGEGLGDASDPYTFEDGDIKYSFTGNKKCKLVAEKDLLKKNKLEDGIGTKEIPATGHSTPVPDGKDAMSIFSSAPKTDTRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMSYKDGISSETVTTLGMMESPMVSMVPTQLAEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSVFAPLKILPSQCLLPLKIPDACVFRPSWAVPPKIEQLPLPPATFIRDGYNNVPSVGSLADQDYLQMNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQPIPEAHSLYVTLILSDSVLNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFIEDELDIFGKTSDIGQAAERRLMICQSNLISQMGEGARRTQEPPMSLLLLLQNQHTQPFTSLSCLDYMSSNNRQTLPCVNWSYDRLQADSNDSWIECFNALEQGRQYVDNPTGGKVDEALLEMMGTPLSFAVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLDGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWGTEECDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLLPPKYQTPAPASQTQTIPGNTGPVSSNSTCLSTSGAPPTGSSFNSTPNSGTTSLPAGSSSSSGSSVPQLSASSATPNVNQMSAAPTPGFSGNIGSGQNTSTGGNTADRSQGSTGPGGDTEVGQNLAQQQQEGQEGVTERERIGIPTEPESADSNAYPPAVVIYMVDPFTYTADEESASTNFWLLSLMRCYTEMLDNLPENMRNSFILQIVPCQYMLQTMKDEQVFYIQHLKSLAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIDLPNRSRRTKLSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKEVCRMCGISSADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPTNDDMFDLPFPDDMDNDIRILITGNLHSSPNSSPVPSPGSPSGIGVGSHYQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISIAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNIL
Length2036
PositionMiddle
OrganismCallipepla squamata (Scaled quail)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Odontophoridae> Callipepla.
Aromaticity0.07
Grand average of hydropathy-0.378
Instability index59.80
Isoelectric point5.56
Molecular weight222915.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14258
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.26|      16|      16|    1371|    1386|       1
---------------------------------------------------------------------------
  878-  892 (21.48/ 8.49)	PRTPRGGGTASGQGS.
 1371- 1386 (28.80/14.73)	NSTCLSTSGAPPTGSS
 1388- 1403 (29.99/15.75)	NSTPNSGTTSLPAGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.65|      17|      17|    1438|    1454|       2
---------------------------------------------------------------------------
 1438- 1454 (30.90/17.14)	GSGQNTSTGGNTADRSQ
 1458- 1474 (31.76/17.84)	GPGGDTEVGQNLAQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.12|      51|     198|     132|     190|       3
---------------------------------------------------------------------------
  132-  188 (81.35/49.50)	GVRMVYPSAFVLISQS.DIPMSQNVASTGGHINVGQqgLGSVKDPSStcgmPLTPPTS
  332-  383 (89.77/33.13)	GLAGMEPSLEVPNSRKyEKPLSIPARNPSKQMNMNP..MDSPHSPSS....PLPPTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.41|      89|    1229|     583|     695|       4
---------------------------------------------------------------------------
  479-  579 (131.59/72.90)	AKMEGNSD.....STALKRLLAQPNKrfkilEEQKPVQTLSYLDPLPLIQQPGEGLGDASDPytfEDGDIKYSFTGNKKCKLVAEKDLLKKnkleDGIGTKEIPAT
  583-  677 (139.82/95.85)	TPVPDGKDamsifSSAPKTDTRQDNA.....AGRAGSGSLTQVTDLAPSLHDLDNIFDNSDE..dELGAVSPALRSSKMPAVGSEERPVGK....DGRTAVPYPPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.12|      42|     426|    1088|    1212|       5
---------------------------------------------------------------------------
   78-  121 (72.43/20.58)	TGQSYKMSDPATRKLmeEWQYFYPMVLKKKEGMKEEEE........LGYDND
 1163- 1212 (74.69/178.87)	TGRTWENIQHVQGPL..TWQQFHKMAGRGTYGSEESPEplpiptllVGYDKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.41|      55|     426|    1484|    1599|       6
---------------------------------------------------------------------------
 1500- 1555 (91.25/56.08)	YPPAVVIYMV..DPfTYTADEESASTNFWLLSLMRCYTEMLDNLPENMRNSFILQIVP
 1601- 1657 (87.16/94.01)	FGPAASIEMTlkNP.ERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     223.42|      55|     424|     264|     328|       7
---------------------------------------------------------------------------
  264-  328 (89.32/59.00)	PPTINQ.PGFSvgassssaLP.PPASSKHKATERQDKGEKLQKRPMM.PFHhrPSVTEELCVE.QDTSG
  688-  742 (82.89/38.83)	PPSLEQhPAFS...........PVMSYKDGISSETVTTLGMMESPMV.SMV..PTQLAEFKMEvEDGLG
  799-  833 (51.22/21.07)	PPKIEQ.............LPlPPA.........TFIRDGYNNVPSVgSLA...........D.QDYLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.51|      27|     424|    1561|    1599|       9
---------------------------------------------------------------------------
  437-  475 (30.75/ 8.08)	ETALYcgiIQNNESLdmwrTYSVPSsddlEFRPPdLPCE
 1566- 1592 (52.76/36.25)	EQVFY...IQHLKSL....AFSVYC....QCRRP.LPTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.79|      14|      16|     384|     398|      11
---------------------------------------------------------------------------
  384-  398 (23.92/15.93)	PQPRGQEAEnLDP.PS
  403-  417 (22.87/10.02)	PALYGSGLE.LQPlPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.48|      26|    1229|      20|      46|      13
---------------------------------------------------------------------------
   20-   46 (45.43/36.65)	LSCAFTFFlHGESNVCTSVEIAQHQPI
 1251- 1276 (49.06/34.65)	LDGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14258 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPV
2) GSLADQDYLQMNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQ
3) KDPSSTCGMPLTPPTSPEQAVMGESGCSQSSISHSAVQEGTVSVHSPKKSSKITPKF
4) KLEDGIGTKEIPATGHSTPVPDGKDAMSIFSSAPKTDTRQDNAAGRAGSGSLTQVTD
5) NLHSSPNSSPVPSPGSPSGIGVGSHYQHSRSQGERLLSREAPE
6) PPKYQTPAPASQTQTIPGNTGPVSSNSTCLSTSGAPPTGSSFNSTPNSGTTSLPAGSSSSSGSSVPQLSASSATPNVNQMSAAPTPGFSGNIGSGQNTSTGGNTADRSQGSTGPGGDTEVGQNLAQQQQEGQEGVTERERIGIPTEPESA
7) VFKQRCAAGSSRPPTINQPGFSVGASSSSALPPPASSKHKATERQDKGEKLQKRPMMPFHHRPSVTEELCVEQDTSGQKLGLAGMEPSLEVPNSRKYEKPLSIPARNPSKQMNMNPMDSPHSPSSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGSGLELQ
624
824
173
566
1872
1346
252
700
922
229
622
1914
1495
413










Molecular Recognition Features






MoRF SequenceStartStop




NANANA