<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14255

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCFVPNGASLEDCHSNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRELWIFWWGDDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSLNEDFWSLLIQDYGMVCFFSLPSEHLSCSFTFFLHGDSNVCTSVEISQHQPVYLLSEEHLTLAQQSNSPFQVILSPFGLNGTLTGQSFKLSDSSTKKLIGEWKQFYPVTSNLKEGSEEKQEDMDWEDDSLAAVEVLVAGVRMVYPACFVLVPQTDIPAPSTVGTSHCSTTCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQKWVKFSSVSDGFISDSTSHHGGKIPRKLANQVVDRVWQECNMNRTQNKRKYSATSNSLCDEETADKVASWDFVEATQRTNCNCSRHKNLKPRNSGQQGQAPPVGQQQQAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLVMTAPDSQVRFSNIRTNDVAKTPQMHNAEMHNAEMANSPQPPPLSPHPCDVVDEGVTKAPSTPQSQHFYQMPTPDPLVPTKTMEDRLDGLSQPFPAQFPEVIEPTMYIGTAVNLEEDEADTTWKYYKVPKKKDVEFLPPQLPNDKLRDDPVIPAGQENITSVTELMVQCRKPLKVSDELVQQYQSKNQYLAAVVSEADQEPEIDPYAFVDGDVEFLFPDSKKDRQNIERETGKKHKAEDGTSGVTVLSHEGEDAMSLFSPSVKQDAQRIAAHARTASTSLIHETDLVVSYTDLDNLFNSDEDELAPGSKRTVNGADDKSNCKEAKAGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTLGGTVLEGNSSSMGAQFRIEVDEGFCSPKPAEIKDYSYVYKPENCQALVGCSMFAPLKTLPSQCLPPIKLPEECIYRQSWTVGKLDLLPPGPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPGSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNSSGLFLEDELDILGRNTECGKEAEKRFEALRATSVEHGSGGLKEPEKLPDELILLLQDQCTNLFSPFGAADQDPIPKVGAVSNLVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKTTCLHHWSKRNVVDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDVAYVVVCPENEALLNGAKSFFRDLTAIYESCRLGQHRPICKLLPDGIMRVGPTASKKLSEKLVTEWFSQTANANNEAFSKLKLYAQVCRYELGPYLASQPLDNSLLAQTNLVPPSSQPASALPPVTASTGNPNTPSAPVASTSSTMTATSNSAMSSAATTANSTLTTTATSSSSANIGSGIPTNKPSSFPPFSSMNNTTSASLPSQAATVQNGQTGGQQQQPVLQTAGMSGDAATAPAQPHPEVSESTMDRDKVGVPTDGDSHAITYPPAIVVYIIDPFTYEKKDESSSSSSLWTLGLLRCFLEMVQVLPPNVKNIISVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPSSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDLYGEQLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKGNVCILDSKTSTVLIDKPISFVSSDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASSTYTTENLDLAFNTNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDMGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length2230
PositionMiddle
OrganismCallipepla squamata (Scaled quail)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Odontophoridae> Callipepla.
Aromaticity0.07
Grand average of hydropathy-0.387
Instability index51.29
Isoelectric point5.35
Molecular weight245343.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14255
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     268.66|      53|      67|     477|     529|       1
---------------------------------------------------------------------------
  477-  529 (91.65/50.17)	PKHKTNEKQDK..GDK.PQKRPLT.P..FHHRVSIS....DDVAMEADSA..SQRLV.MTAPDSQV
  543-  598 (75.62/39.96)	PQMHNAEMHNAemANS.PQPPPLS.P....HPCDVV....DEGVTKAPSTpqSQHFYqMPTPDPLV
  600-  639 (29.29/10.45)	....TKTMEDR..LDGlSQPFPAQfPevIEPTMYIG....TAVNLEEDEA................
 1622- 1672 (72.10/37.72)	PVLQTAGM..S..GDA.ATA.PAQ.P...HPEVSEStmdrDKVGVPTDGD..SH..A.ITYPPAIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     243.21|      62|      71|     954|    1022|       2
---------------------------------------------------------------------------
  921-  961 (48.16/17.83)	.....................PKPAE..IKD..........YSYVYKPencQALVGC.SMfAPLKTLPSQCLPPI
  962- 1030 (115.40/68.66)	KLPEECIYRQSWTvgkldllPPGPAMPFIKDGDGSTMDQE.YGPAYTP...QTHTPF.GM.PPGSAPPSNGGAGI
 1038- 1093 (79.65/37.47)	RFPTPRTPRTPRT.......PRGAGGPASAQGSVKYENSDlYSPASTP...STCRPLnSV.EPATVP........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.60|       9|      71|    1149|    1165|       3
---------------------------------------------------------------------------
 1126- 1134 (20.52/ 7.41)	CVCN....MNIK.G
 1152- 1165 (11.08/14.41)	CTCGfsavMNRKfG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.47|      18|      20|    1498|    1515|       4
---------------------------------------------------------------------------
 1498- 1515 (32.43/18.35)	SQPLDN..SLLAQT.NLVPPS
 1516- 1536 (24.03/11.41)	SQPASAlpPVTASTgNPNTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.62|      13|      78|     653|     665|       6
---------------------------------------------------------------------------
  653-  665 (25.87/14.53)	DVEFLPPQLPNDK
  732-  744 (24.76/13.54)	DVEFLFPDSKKDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.78|      15|      20|    1345|    1364|       7
---------------------------------------------------------------------------
 1345- 1364 (21.23/22.01)	FhkMAGrgsYGTD...ESPEPLP
 1368- 1385 (23.55/ 9.28)	F..LLG...YDYDflvLSPFALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.32|      27|    1062|     671|     697|       8
---------------------------------------------------------------------------
  671-  697 (46.26/23.61)	VIPAGQENITSVTELMVQCR...KPLKVSD
 1708- 1735 (37.37/17.74)	VLPPNVKNIISVQ..IVPCQyllQPVKHED
 1736- 1761 (36.69/17.29)	RQIYTQHLKSLAFSAFTQCR...RPLPSS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.57|      16|      20|    1537|    1552|      11
---------------------------------------------------------------------------
 1537- 1552 (27.85/15.50)	A..PVASTSSTMTATSNS
 1558- 1573 (24.86/13.00)	A..TTANSTLTTTATSSS
 1588- 1602 (17.86/ 7.14)	SfpPFSSMNNT...TSAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14255 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSKKDRQNIERETGKKHKAEDGTSGVTVLSHE
2) GPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPGSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
3) GSPVHSPGSHYPHGGDMGKGQGTDRLLSTESH
4) LAQTNLVPPSSQPASALPPVTASTGNPNTPSAPVASTSSTMTATSNSAMSSAATTANSTLTTTATSSSSANIGSGIPTNKPSSFPPFSSMNNTTSASLPSQAATVQNGQTGGQQQQPVLQTAGMSGDAATAPAQPHPEVSESTMDRDKVGVPTDGD
5) NCNCSRHKNLKPRNSGQQGQAPPVGQQQQAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLVMTAPDSQVRFSNIRTNDVAKTPQMHNAEMHNAEMANSPQPPPLSPHPCDVVDEGVTKAPSTPQSQHFYQMPTPDPLVPTKTMEDRLDGLSQPFPA
739
984
2077
1506
446
770
1069
2108
1661
616










Molecular Recognition Features






MoRF SequenceStartStop




NANANA