<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14252

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAPEYRVGVMSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVVCIAEKDEKKNAFMFWNCGFAFVFLKKMDYIEHSAKPNVIPSLLVLVEDFAVLIFYSCCAAQRLKLMHLTLILLCVLSLSELSRIGATSEKQSLMCNRSEYILLFPPFTFREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVILHENNVPRSLGMNVSVTVEGTMAMYKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQGCTGIPLFDTAPTFVPLYELITQFELSKEADPVPLNHNMRFYAVTRKVAWHHLSLESALAVCYCLVIALNTSWNKAQIVCQALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSAIGSSPTPPHHTPPPLSSPAGNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGSKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPGIQRMVRLSSSDSIGADVTDILSDIAEEASKLPATNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFAEEYFDESSQSGDTDDFKGYASQALSTLGVQVLGGDGGENKFKGSNQSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSNMAGSGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSSSGPSKSSAQSVGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSEKEKSKVSVSGGSVDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSIKPESWSKSPISADQSLSMASSAILSAERPSRASPEFLIGEEDDDLMDVALIGN
Length1660
PositionMiddle
OrganismCallipepla squamata (Scaled quail)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Odontophoridae> Callipepla.
Aromaticity0.05
Grand average of hydropathy-0.532
Instability index53.56
Isoelectric point8.75
Molecular weight176742.50
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14252
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            13|     871.87|      84|      84|    1232|    1315|       1
---------------------------------------------------------------------------
  618-  680 (46.01/ 8.32)	..........................L....PPAS...SPG...................Y........GMttgsNP....MS...G...TT...........TPTN...T.FPG.G........PITTLFN.MSI......SM.K..ERhDS..V...GHG.ED......FS.KVS.QN.......................P
  698-  761 (61.78/13.77)	SSPTPP..HhtppPL.SSP.A.GNTKN....HPM...................................LM....N.....LL..KE...NP...........PQDF...S.TLY.GS.................................SP..LerqNSS.SG......SP.RMEmGP.......................G
  762-  858 (65.67/15.11)	GSKQKK..K.......KSR.M.PADKP....KHQT...EDDfqrelfsmdvdsqnpifdvN........MT....ADT...LD..TP...HI...........TPA.......PS.QCSTP.PTTYPQPIPH.SQP......GI.Q..RM.VR..L...SSSdSI......GA.DVT.D.........................
  860-  934 (44.04/ 7.65)	..............L.SDI.A.EEASK....LPAT...NED...................C...............PP...IG..TPvrdSS...........SSGH...S.QSAlFDPDV.FQTNNSENPY.TDP......ADlI..AD.AA..V...SPN.SD......SSnHF............................
  936- 1005 (39.94/ 6.23)	................................PDGvdfNP....................D........LL....N.S...QS..QS...GF...........AEEYfdeS.SQS.GDTDD.F....KG.YA.SQA......LS.T..LG.VQ..V...LGG.DGgenkfkGS.NQS.DT.......................V
 1007- 1062 (59.08/12.84)	FSIIAA..A....SK.ALG.S........................................................S............DI...........MEHH......S..GGQ.....SPL...LN.TGD......LG.K..EK.SQkrV...KEG.NG.....sGS.NMA.GS.......................G
 1063- 1131 (45.93/ 8.30)	........................IDG....KP.G...KRS...................R..............TPSsdgKS..KE...KLpkrkkqetdgkSPSH...S.............SSNRPF...TPP......AS.TggSK.SP..G...SSG.RS......QT.P.P.GV.......................A
 1132- 1231 (69.65/16.48)	TPPIPK..I....TI.QIP.K.GTVTV.......G...KPS...................ShgqytssgSV....TSS...SS..KS...HH...........SHSS...S.SSS.SSS.....S......S.T........SG.K..IK.SS..K...SEG.SS......GS.KMS.SSlyssqggsssgpskssaqsvgkpG
 1232- 1315 (153.97/45.58)	SSPITK..H....GL.SSG.S.GSTKM....KPQG...KPS...................S........LM....NPS...MS..KP...NI...........SPSH...S.RPS.GGSDK.LASPMKPVPG.TPP......SS.K..AK.SP..I...SSG.SG......GS.HMS.GT.......................G
 1316- 1382 (73.19/17.71)	SSSSMKssS....GMgSSG.S.MSQKP....PPSS...NSS...................T........AS....SSS...FS..SS...GS...........SMSS...S.QNQ.HG......S..................S.K..GK.SP..........SR......NK.KPS.LT.......................A
 1383- 1450 (67.94/15.89)	VIDKLK..H....GVvTSGpG.GDDPM....DGQM...GPS...................S................N...SS..SH...TM...........SSKH...N.M.S.GG.E......FQ...GkREK......SE.K..EK.SK..V...SV..SG......GS......V.......................D
 1451- 1545 (71.36/17.07)	SSKKTS..D....SK.NVG.StGVAKIiiskHDGG...SPS...................I........KA....KVT...LQ..KP...GE...........GGGD...SlRPQ.MASSKsYGSPL..ISG.STPkhercsPS.H..SK.SP..A...YTP.QN......ID.SES.ES.......................G
 1546- 1625 (73.32/17.75)	SSIAEK..S....YQ.NSP.S.SDDGI....RPLP...EYS...................S........EK....HKK...HKkeKK...KV...........KDKD...R.DRD.RDRDK..DRDKKKSHS.IKP......ES.W..SK.SP..I...SAD.QS......LS..M............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.11|      44|     104|     332|     379|       2
---------------------------------------------------------------------------
  332-  379 (77.97/56.26)	TSANSVD.....LPA...CFFLKFPRPIPVSRAfiqkLQGCTGIPLFDTAPTFVPL
  433-  484 (73.14/43.65)	TSWNKAQivcqaLPGqqhCYFLNKDAPLPDGRS....LQGTLISKIAFQHPGRVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.21|      26|     104|     179|     204|       3
---------------------------------------------------------------------------
  179-  204 (47.50/30.72)	PFTFREKNFD.....EFSKHLRGLVNLYKLP
  279-  309 (40.71/25.30)	PVILHENNVPrslgmNVSVTVEGTMAMYKLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14252 with Med1 domain of Kingdom Metazoa
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