<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14250

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYVCEWEKRPKSDHCPSIPLVCAWSCRNLIAFTTDLRNEEERDLTHMVHIIDTEHPWDVYSVNSGHGCVFAGSRLLSADADGHIKCWSMTDHLANSWENTVGSMVEGDPVVALSWLHNGVKLALHVEKSGASNFGEKFSRVKFSPSLTLFGGKPMEGWIAVTISGLVTVSLLKPNGQVLTSTESLCRLRCRVALADVAFTGGGNIVVATSDGSSASPVQFYKVCVSVVNEKCKIDTEILPSLFMRCTTDPARKDKYPAITHLKFLARDMSEQVLLCASNQNNSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLGLALAFHDGSVHIVHRLSLQMMAVFHGSSSQRPVDEQTIKRQRTTGPLVHFKAMQLSWTSLALAGVDSHGKLSMLRISPSMGHVLDMNTSLRHLLFLLEYCMVTGYDWWDILLHVQPNMVQNLVEKLHEEYTRQSAALQQVLATRIVAMKASLCKLSSSTIARVCDYHAKLFLIAISCTLKSLLRPHFLNTPDKSPGDRLTEICSKITDIDIDKVMINLKTEEFVLEMNTLQSLQQLIQWVGDFVLYLLASLPNQGSPVRPGHSFLRDGASLGMFRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWLCCREESHITEPDDTLIDECCLLPSQLLIPNIDWLPINDGIISKLQNKQLVRLQFGKAPGLIGHTVSSQFDAFVRAPGQPKIDHLRRLHLGAYPTEECKSCTRCGCVTMLKSPNKVTAVKQWEQRWVKNCLCGGLWRRMPLSYS
Length823
PositionTail
OrganismCallipepla squamata (Scaled quail)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Odontophoridae> Callipepla.
Aromaticity0.07
Grand average of hydropathy0.003
Instability index45.23
Isoelectric point8.24
Molecular weight91888.80
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14250
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.63|      15|      96|     315|     331|       3
---------------------------------------------------------------------------
  315-  329 (27.19/20.21)	QPMILKWRILSATND
  341-  355 (24.44/10.41)	LPISLTNTDLKVAND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.70|      47|     139|     446|     500|       4
---------------------------------------------------------------------------
  446-  500 (63.84/77.55)	VLDMNTsLRHLLFLLEYcmvTGyDWWDILLHVQPNmvQ.NLVEKLHeEYTRQSAAL
  587-  634 (80.87/58.74)	VLEMNT.LQSLQQLIQW...VG.DFVLYLLASLPN..QgSPVRPGH.SFLRDGASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.89|      33|     200|      78|     111|       5
---------------------------------------------------------------------------
   78-  111 (57.62/33.92)	LL..SADADGHIKCWSM.TDHL.ANSWENTVGSMVeGD
  277-  313 (45.26/22.41)	LLcaSNQNNSIVECWSLrKEGLpVNNIFQQISPVV.GD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.98|      14|      17|     728|     743|       6
---------------------------------------------------------------------------
  728-  743 (22.14/22.07)	QLVrlQFGKAPGL..IGH
  748-  763 (22.85/14.77)	QFD..AFVRAPGQpkIDH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14250 with Med16 domain of Kingdom Metazoa
Unable to open file!