<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14226

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMGGSIREEVEVALHEHRFLVTKLLEALNTASLPPSTITTTRLRTVNETFNKVLEKDRDLLTAVKKLARHQVAQKELLRIEAEVENKKQRVVQYAAQLRRSQEDIANVLRKHRVVLQNAKQKSKVALDPRDIVAYAHRIAGTTSAPREWQPGFPMFGFMPPAPQEHMMRAGVLSRGIVAEIVTQGPEKYTSTAARVKQDDGESIEKLNIPIGLGASDAQIRKQMPPGWKPGDPVDLPLDALLHYMGRSFFTEHGITLPESWKTGDPLPADAMEILRKKFKLPEKRAALYDDEVVDDVESLRKKRKLEEGDKTEEGTVESDSSSDSSDSDEEAPNTISLSLSSSEDESDDDSD
Length351
PositionMiddle
OrganismPhytophthora megakarya
KingdomOomycetes
LineageEukaryota> Sar> Stramenopiles> Oomycota> Peronosporales> Peronosporaceae> Phytophthora.
Aromaticity0.05
Grand average of hydropathy-0.638
Instability index55.34
Isoelectric point5.47
Molecular weight39183.75
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP14226
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.22|      22|      22|     256|     277|       1
---------------------------------------------------------------------------
  223-  247 (34.11/19.66)	MPPGWKP.GDPvdLPLDAlLHYMGRS
  256-  277 (42.28/26.03)	LPESWKT.GDP..LPADA.MEILRKK
  280-  302 (29.84/16.33)	LPEKRAAlYDD..EVVDD.VESLRKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.13|      17|      22|      71|      92|       2
---------------------------------------------------------------------------
   75-   91 (26.94/24.89)	ELLRIEAEVEN..KKQRVV
   96-  114 (24.19/ 6.07)	QLRRSQEDIANvlRKHRVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.46|      11|      22|     320|     330|       3
---------------------------------------------------------------------------
  320-  330 (19.41/10.80)	SSSDSSDSDEE
  341-  351 (20.05/11.37)	SSEDESDDDSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14226 with Med4 domain of Kingdom Oomycetes


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ESLRKKRKLEEGDKTEEGTVESDSSSDSSDSDEEAPNTISLSLSSSEDESDDDSD
297
351










Molecular Recognition Features






MoRF SequenceStartStop




1) LRKKRKLE
2) MEILRKKFKL
3) SDSDEEAPNTISLSLSSSEDESDDDSD
299
271
325
306
280
351