Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNAQLSSALDGLESKLNFLLTSLTTPAAVGAPAAAIALLEADDVVSSALDTLRTHQANYAKILHLRSEAQILEDRIKTIVRDISGAGKEIAEATGENEDEDYDNSTDDESGTDTESENDEAIAQKLNKGGRKKEVDYKLLLEFARRISKYNKQAAADATLGVLETTGSTKQLQEKQTEDTKMTDADGLDTRQEGDTAEVTVGAVTKEATSWLDESADADRQFFMIPYPNEDRIRMGLMGQLQLAALDGNIDPEKEAERMVQEAEGTGVAGAIPNAQVPGISQSLADEAGKAAIHAGSQAMDKALASAAKVAVPASQPKSMLDLDLYDPEDDD |
Length | 332 |
Position | Middle |
Organism | Talaromyces atroroseus |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Trachyspermi. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.505 |
Instability index | 34.76 |
Isoelectric point | 4.34 |
Molecular weight | 35459.69 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP14218 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 70.70| 23| 39| 156| 194| 1 --------------------------------------------------------------------------- 156- 179 (32.97/45.89) ADATLGVLeTTGSTKQLQEKQTED 197- 219 (37.73/14.59) AEVTVGAV.TKEATSWLDESADAD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 80.15| 28| 33| 253| 284| 2 --------------------------------------------------------------------------- 253- 282 (39.42/35.14) E..KEAERMVQEAEGTGVAGAIPNAqVPGiSQ 287- 316 (40.73/20.69) EagKAAIHAGSQAMDKALASAAKVA.VPA.SQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ALASAAKVAVP 2) PKSMLDLDLYDPEDDD 3) RKKEVDYKLLLEFARRISKY 4) RQFFMIPYP | 303 317 131 220 | 313 332 150 228 |
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