<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14213

Description Mediator of RNA polymerase II transcription subunit 21
SequenceMSRPGKSIKAFPDVQRPSNKSTSQLATQFYATLCYLSTYHDHVPATIPPPAAGIVDAMPPLAKIPRNQPSAAPMPAGAAAKQNAEQQQQQGQGSPSQGPAGSAAAETSTLPPSAAGAVSLTPGQGDPNQPPQPDSPQLFLFRQKELARDLIIKEQQIEYLIGRLPGIGASEAEQEARIRELESELRQVELAREKKARELKKLGKRLESVLGAVERGIYSRQERNGLN
Length227
PositionMiddle
OrganismTalaromyces atroroseus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Trachyspermi.
Aromaticity0.04
Grand average of hydropathy-0.636
Instability index59.38
Isoelectric point9.21
Molecular weight24403.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU366036

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14213
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.74|      38|      41|     132|     171|       1
---------------------------------------------------------------------------
  125-  167 (56.80/40.33)	GDPNqppQPDSPQL.FLFRQKELARDliIKEQQIEYLIGRLPGI
  168-  209 (48.94/28.90)	GASEaeqEARIRELeSELRQVELARE..KKARELKKLGKRLESV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.59|      14|      60|      46|      59|       2
---------------------------------------------------------------------------
   46-   59 (28.69/13.54)	TIPPPAAGIVDAMP
  109-  122 (25.90/11.63)	TLPPSAAGAVSLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.13|      15|      22|      66|      80|       3
---------------------------------------------------------------------------
   66-   80 (28.48/13.65)	RNQPSAAPMPAGAAA
   90-  104 (28.66/13.78)	QGQGSPSQGPAGSAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14213 with Med21 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATIPPPAAGIVDAMPPLAKIPRNQPSAAPMPAGAAAKQNAEQQQQQGQGSPSQGPAGSAAAETSTLPPSAAGAVSLTPGQGDPNQPPQPDSPQLFL
45
140










Molecular Recognition Features






MoRF SequenceStartStop




1) KSIKAF
6
11