Description | Mediator of RNA polymerase II transcription subunit 20 |
Sequence | MPHTGVYFIPSSPSAPHILGPLTERLRSVYGDQAIPIGRWGLEHKLMRDTPSCLPASAHAPNPAPSKARYVQFLSMTNYPKLGFIYASEDDNDGNDPVAQQQTASGMIMSTVPIPSAAEIFRHFVRNCEPIWCHRHTVTVTGTVYDVGDFRVRLGELRQMQPQARVRGTIMEIEWRGPSVITAALSSTFLNSHKAKNDPDNDLAPIADTMDIDAKIEEAAEETPYIPTEAEINTEYTQIAQLIRDFWAHLAITQHIIADTKQQAAIRESILVADVGREVKIKLSQRRSPAEGGVKWQEREIRRRQKRREAIALDRSWGGGSGMSQQQLQEDEEEELEGGVDLARQYMELFRFSR |
Length | 354 |
Position | Head |
Organism | Talaromyces atroroseus |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Trachyspermi. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.505 |
Instability index | 62.15 |
Isoelectric point | 5.75 |
Molecular weight | 39830.50 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364152 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP14211 No repeats found |
MoRF Sequence | Start | Stop |
1) ALDRSWGG 2) LQEDEEE 3) QYMELFRF | 312 328 345 | 319 334 352 |
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