<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14207

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDHGSRNGSHTNHDRDQRPNGTNGVSRASEKTQDKGKARAEPLQSMTPTSPTIPDGLNGNTTGPLRHENGANGILRDEQVQMNQLPPEIAHIADGYMPLSALLIRLAQKSHAGLLSAMSDLVQMPTPAAVVNGSASHHSSMEDASYENVQKKLRLLNFATTTHESWTKALVITGWSRKSEEVSKLVDLRIHLEAQKLLYTEAIDSMANNKRAIHNFRLPNPDFKTALEVLTTGSASWMPDLNYIQPRPLTAKEVLRSLEKLNTLLSIRLNLDDYDTIPPQFRDFTIQSGRATFRVPGEFEIDLTIADEEPGSQYWFIDFRFLFRPSSSNMSSGIRWHLENKVNEVLLKDGLTGCYKYLHELILTYKIAEFRRQGNELARSIWIDTLKVEILNRPICIQYWMDRYSGRLLDGRPANVKPSKSWIILGVHSGRRNDGRPDSKATSRLFIRWFRESKEVTDEDIWFDDVNISTESLLKTVIAKHISHILTSMYEKLSAKPLYAKRELELSLKLSSDDPADLEIKIQLTNEHHLSIKIDPISGRFVFGPISRIFSHYEGLLNTVCQDPATDGHTAIERLRSALVTDAIQIHASSMSWSRVNNPGLSQDSLNQFVPKDSLATIWFRRPGWVKDWYLAVTQSMSGEKWHLIKTAIIPTPVKSSAVGLGCFLELPIKGASPSPTYSFLSTLNNFAAGMISHYTNTRMLHSRRVHHMLGKGKIARSIKLPAIYAKLSELIPSKNRLPRTGRNWAKDIIKIYFHGVEVIAQRSKDPAELGPSQSTLVSQVSASSLPTSSVLDSQKTFELDERSVLVVEARMVMPIPQALSNINEQHDKHIVFDAKTGSLAFRLQSQVGESVVPELIERIVGVERLVEFVQVIQLHDGTLRCETVSLGKLVFTYPNTQLVAKPDSMDIDNASLTYKATIDFSAVDNIMKLVLESGNPHLRIADNLTKILNGPEGLGGIATLLPLTLPVLRGLDAVESAWYMDDMFEKGEVIVNVRATDVYRLRYSLHQISSHTSNPLTIIRKVGFEIKLRSRKAEAWWYVQRVDNFRQKGLDALDEALKSVWDISGPDWRGMRICAVAKNNGIELLLLKLDEVVRNFVLSGKSLDSPVAAPQASAPAPPKQAPNPRMQQQQRQQQRHQQPSANHNQSQGRNNNHNNQSREIVEID
Length1165
PositionTail
OrganismMarssonina coronariae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Dermateaceae> Marssonina.
Aromaticity0.07
Grand average of hydropathy-0.364
Instability index42.87
Isoelectric point8.89
Molecular weight130872.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14207
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     169.37|      52|     226|     204|     261|       1
---------------------------------------------------------------------------
  204-  233 (33.33/18.01)	.................................................DSMANNKRAIHNFRLPNpDFKTALEVL..TTG
  234-  311 (58.00/43.10)	SASWmPDLNyiqpRPLTAKEVLRSLEKLntllsirlnlddydtippqfrDFTIQSGRA..TFRVPG.EFEIDLTIAdeEPG
  438-  458 (23.25/ 6.91)	.................................................DSKATSRLFIRWFRESK.......EV....TD
  590-  624 (54.79/28.40)	SMSW.SRVN....NPGLSQDSLNQFVPK.....................DSLAT....I.WFRRPG...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.27|      11|      15|     382|     392|       2
---------------------------------------------------------------------------
  382-  392 (19.01/10.57)	WIDTLKVEILN
  400-  410 (21.26/12.64)	WMDRYSGRLLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.57|      15|      15|     941|     955|       3
---------------------------------------------------------------------------
  941-  955 (25.69/16.06)	IADNLTKILNGPEGL
  958-  972 (24.89/15.32)	IATLLPLTLPVLRGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     256.22|      81|     225|     486|     583|       4
---------------------------------------------------------------------------
  487-  580 (117.19/93.22)	TSMYEKLSAKPLYAKRELELSLKLssddPAdleIKIQLTNEHHLSIKIdPISGRFVFGPISRIFSHYEGLLNTVCQDPATDGHTaierlRSALV
  698-  778 (139.03/70.40)	TRMLHSRRVHHMLGKGKIARSIKL....PA...IYAKLSELIPSKNRL.PRTGRNWAKDIIKIYFHGVEVIAQRSKDPAELGPS.....QSTLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.79|      36|     307|     315|     355|       5
---------------------------------------------------------------------------
  315-  354 (54.35/51.32)	WFIDFrFLfrPSSSNMSSGIRWHL.ENKVNEVLLKD...GLtGC
  625-  663 (55.82/34.72)	WVKDW.YL..AVTQSM.SGEKWHLiKTAIIPTPVKSsavGL.GC
  679-  697 (20.62/11.12)	SFL.......STLNNFAAGMISHY.TN.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.46|      13|      50|      20|      33|       7
---------------------------------------------------------------------------
   20-   33 (19.50/14.93)	NGTNGVSRaSEKTQ
   69-   81 (23.96/13.72)	NGANGILR.DEQVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14207 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSPVAAPQASAPAPPKQAPNPRMQQQQRQQQRHQQPSANHNQSQGRNNNHNNQSREIVEID
2) MDHGSRNGSHTNHDRDQRPNGTNGVSRASEKTQDKGKARAEPLQSMTPTSPTIPDGLNGNTTGPLRHENGANGILRDEQVQMNQLPPEIAH
1105
1
1165
91










Molecular Recognition Features






MoRF SequenceStartStop




NANANA