Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLQHQIAQSPARLGLTNPNSPSLQSPPPPQPPPKFSSATQQNQLQQHPNLATTPATSSALLSLLPPLQRAQSLLLQMASLASRLFEVSPNRSLWLTSFRGTLPTFLPSQSQSAVAQAPSDQSPSSPKEVLSLFTSLQTQLFEAVAELQEILDLQDVKQKVAREIRSKDAALLAFAHKLKEAERVLDVLVDDYSDYRRPKMSKLKDSEEDESSCTTVASQLNLSDIISYAHRISYTTFAPPEFGAGQAPLRGALPPAPQEEQLRASQLYNFADLDIGLPKTVETKEKTVEPIIEPALVPDANNPLANLAAIQGLLPPNITVPSGWKPGMPVELPTDLPVPPPGWKPGDPVPLPPLDSLAVPRAEETQLRPVAPPGPRREPEVIQVRHVDLELPDNFDDSSDYSSDEGSSEEDD |
Length | 412 |
Position | Middle |
Organism | Punica granatum (Pomegranate) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Myrtales> Lythraceae> Punica. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.427 |
Instability index | 82.32 |
Isoelectric point | 4.72 |
Molecular weight | 44829.97 |
Publications | PubMed=28654223 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP14199 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.32| 17| 17| 317| 333| 1 --------------------------------------------------------------------------- 317- 333 (37.32/18.72) NITV.PSGWKPGMPVELP 335- 352 (34.99/17.11) DLPVpPPGWKPGDPVPLP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 64.27| 13| 15| 38| 50| 2 --------------------------------------------------------------------------- 17- 29 (22.01/ 9.61) NPNSPSLQSPPPP 38- 50 (23.49/10.81) ATQQNQLQQHPNL 55- 67 (18.77/ 7.00) ATSSALLSLLPPL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ETQLRPVA 2) GPRREPEVIQVRHVDLELPD | 364 374 | 371 393 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab