<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14185

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMAIPMVPMETQLQSIFEEVVKTEVIEEAFPGMFMDTPEDERTKLISCLGAFRQFWSSLSQESHEQCVQWIVRFIHSQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVVAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAMCNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAHSDNSKLQIPIPHSLKLHHEFLQQSLRNKNLQMNDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGNMRTPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPAPLQVFFKQNNVPQESRFNLKKNVEEEYRKWKSMTSENEIITHFSAQGSSPLFLCLLWKMLLDTDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMSYHKKYPEKLYFEGLAEQVNPPVQIQPQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEGHLRERTNLKRKLVHAIIGSLKDNRPLGWCLSDTYLKCAMNPREENPWVPDDAYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDCIVNVINSPSLTSETEWVGYPFQLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEALIPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYEMLLNADRYSSHLNYMDPICDFLYHMKYMFTGDSVKDQVEKIICNLRPALKLRLRFITHISKMEPAAVSQQPLSSGSPAQQPSQVPVNVALPVTQ
Length1377
PositionTail
OrganismLonchura striata domestica (Bengalese finch)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Lonchura.
Aromaticity0.10
Grand average of hydropathy-0.020
Instability index45.23
Isoelectric point7.09
Molecular weight157537.33
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14185
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.92|      31|     674|     404|     435|       5
---------------------------------------------------------------------------
  404-  435 (53.64/44.75)	KLFDLLyPEKEYIPVPDI....NK.PQ.STHAFAMTCI
 1081- 1117 (45.28/31.13)	RLVDTM.AGKSPGPFPNCdwrfNEfPNpAAHALHVTCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.94|      34|     619|     214|     255|       7
---------------------------------------------------------------------------
  214-  255 (45.93/57.87)	DF.VDTFRPTARINSIcGRCslLPVVNNsgaMCnsWKLDPTTL
  835-  869 (58.01/39.49)	DFlVYEFSTSAGGQQL.NKC..IEILND...MV..WKYNIVTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.49|      16|     674|      45|      62|      11
---------------------------------------------------------------------------
   45-   62 (23.66/18.87)	ISCLGA.....FRQfwSSLSQES
  739-  759 (23.83/10.69)	LSCFPAplqvfFKQ..NNVPQES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      32|     346|     355|      16
---------------------------------------------------------------------------
  346-  355 (18.69/13.38)	IFFVLFQFAS
  379-  388 (19.45/14.32)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.51|      16|      19|    1002|    1017|      18
---------------------------------------------------------------------------
 1002- 1017 (32.07/21.07)	YKFHDRPVTYLYNTL.H
 1019- 1035 (23.44/13.35)	YEGHLRERTNLKRKLvH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.90|      55|     861|     271|     325|      21
---------------------------------------------------------------------------
  271-  325 (98.39/65.58)	EPQTALLRYVLE.QP.YSRDMVC...NMLGL..NKQHKQRCPVLEDQLVDLVVYAMERSETE
 1128- 1189 (77.51/50.04)	EVGNALLNVVLKsQPlVPRENITawmNAIGLiiTALPEPYWIVLHDCIVNVINSPSLTSETE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.30|      19|     783|      89|     109|      23
---------------------------------------------------------------------------
   89-  109 (31.47/25.06)	CLAMAVETGllPPRMVCESLI
  875-  893 (36.83/23.01)	CLAMRSHEG..NEAQVCYFII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14185 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA