<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14181

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMFPFCLLSCSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLITEEHIQMAQSSPSPFQVLVSPYGLNGTLTGQSYKMSDPATRKLMEEWQYFYPMVLKKKEGMKEEKELGYDNDFPVAVEVIVGGVRMVYPSAFVLISQSDIPVSQSAASAAGHINVGQQGLGSVKDPVSTCGMPLTPPTSPEQAVMGESGCSQSSISHPAVQEGTVSVHSPKKSSKITPKFHNRIVHRVWKECILNRAQSKRNQITTANLEEEVPNNSVSWDFVDPVQRVSCSCSRHKVFKQRCTGASGRPPTLPQPGFTVGTAAASALPPPASSKHKTTERQDKGEKLQKRPLMPFHHRPSVTEELCMEQDAAGQKLGLAGMESTLEVPSSRKYEKPLSLPARNASKQINMNPMDSPHSPTSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGSGLELQPLPSLDDRTVLVGQRLPLMAEVSETALYCGITQSNEAVDVWRTYSVPSSDDPEFRPPELPCERYDGRMEINPDSTALKRLLAQPNKRFKILEEQKPVQTLNYLDPLPLLQPPGEGWGDTSDPYTFEDGDIKYSFTVNKKCKLGAEKDLLKKNKSEDGIGSKEIPPTGHSTSVPDGKDAMSIFSSAPKTDPRQDSAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKLPAAGSEERPLGKDSRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMSYKDGISSETVTALGMMESPMVNMVPTQLAEFKMEVEDGLGSPKPEEIKHDHIVVTKVTWMLQDFSYVHKVPSFQPFVGSSLFAPLKILPSQCLLPLKIPDACIFRPSWAVPPKIEQLPLPPAATFIRDGYNNVPSVGSLADQDYLQMSTPQMSTPVMLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPGTVQPIPEAHSLYVTLILSDSVLNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFIEDELDIFGKTSDIGQAAERRLMICQSNLISQMGEGARRSQEPPMSLLLLLQNQHTQPFTSLSCLDYMASNNRQTLPCVNLSYDRLQADSNDSWVECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGTYTGLGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVMCRLGQHKPICKVLRDGIMRVGKSVAQKLTDELVSEWFSQPWGSEDCDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLLPPNTSERERIGVPTEPDAADSNAYPPAVVIYMVDPFTYTADEESASTNFWLLSLMRCYTEMLDNLPENMRNSFILQIVPCQYMLQTMKDEQVFYIQHLKSLAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIDLPSRSRRSKLSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKEVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPTNDDMFDLPFPDDMDNDIRILITGNLHSSPNSSPVPSPGSPSGTGVGSHYHHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNIL
Length1932
PositionMiddle
OrganismLonchura striata domestica (Bengalese finch)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Lonchura.
Aromaticity0.07
Grand average of hydropathy-0.336
Instability index61.82
Isoelectric point5.74
Molecular weight212818.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14181
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     624.26|     176|     202|     291|     492|       1
---------------------------------------------------------------------------
  143-  313 (120.98/52.69)	.................................................................PVSQSAASAAGHINVGQqgLGSVKDPVStcgmPLTPP.....TSPE.................QAVM.....GESGCSQSSIshPAVQE....GTVSVHS..PKKSS...KITPKFHNRIVHR.....VWKecILNRAQSKRnqittanleeevpnnsvswdfvdpvqrvscscsrhkvfkqrctgasgRPPTLPQPGFTVGTAAASALPPP
  314-  507 (254.26/172.34)	ASSKHKTTERQDKGEKLQKRPLMPfHHRPSvteelcmEQDAAGQKlglagmestlevpssrkyEKPLSLPARNASKQINMNP..MDSPHSPTS....PLPPT.....LSPQPRGQEAENLDPPSVP.VNPAL.....YGSGLELQPL..PSLDD....RTVLVGQRLPLMAE...VSETALYCGITQSNEAVDVWR..TYSVPSSDD............................................pefRPPELPCERYD.G..........
  508-  648 (142.40/64.63)	............................................................................RMEINP...DSTALKRL....LAQPNkrfkiLEEQKPVQTLNYLDP..LPlLQPPG.....EGWGDTSDPY...TFEDgdikYSFTVNKKCKLGAEkdlLKKNKSEDGI.GSKEIPPTGH..STSVPDGKD........................................amsifssAPKTDPRQDSAAGRAGSGSLTQV
  652-  743 (106.62/50.49)	APSLHDLDNIFDNSDEDELGAVSP.ALRSS.......KLPAAGSE..................ERPLGKDSRTA..................V....PYPPT.....VADLQRMFPT....PPSLE.QHPAFspvmsYKDGISSETV..TAL.............................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     257.51|      92|     498|    1251|    1389|       2
---------------------------------------------------------------------------
 1251- 1389 (117.04/192.51)	LPIPTllvGYDKDF.......LTISPFSLP...fwerllldpygghrdvayivmcrLGQHKPicKVLRDGIMRVGKSVAQKLTDELvSEWFsqpwgsedcDNHSRLKLYAQVCRHHlapYLATLQLDSslLLPPNTSERerigVPTEPD
 1751- 1880 (140.47/97.86)	LPFPD...DMDNDIrilitgnLHSSPNSSPvpspgspsgtgvgshyhhsrsqgerlLSREAP..EELKQQPLALGYFVSTAKAENL.PQWF....wsscpQAQNQCPLFLKASLHH...HISVAQTDE..LLPARNSQR....VPHPLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.87|      46|     496|    1119|    1191|       5
---------------------------------------------------------------------------
  938-  983 (77.72/39.62)	YDSTDQGSPASTPSTTRPLNS..VEPGTVQPIPEAHSLYVTLILSDSV
 1141- 1188 (74.14/ 6.07)	FNALEQGRQYVDNPTGGKVDEalVRSATVHSWPHSNVLDISMLSSQDV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14181 with Med13 domain of Kingdom Metazoa
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