<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14180

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVTGPETDWRSTNFRQKLVSQIEEAMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPAAGAPGMAMASRAQGAPMSGMTGLGPMAQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQTQLQLQQIAQQQQQQQQQFQQQQVALQQQQQFQAQQSAMQQQFQVQQQQAAAAAVAQQQQQQQQQLQAVQQQQQHMLKLQMQQQQNQQQMQQQQQQQQLQRIAQMQQLQAAQVMQAQQQQQQQQQQQQIPQQQIQQQPPQQVMQQQMQQMQQQQQQQQQQQQQQQQVAQAQQSQLPPQSQPQPQPMVSQPQAISGQIPSQVMPVTLTPQQLKAMQVRAQLVQQQQQQAAAAAAVQAAQAQAAQMGASGQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSGQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGQPITAPIVSPRKRKYEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIKNPRQYAANPFLQSVYRYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length766
PositionTail
OrganismLonchura striata domestica (Bengalese finch)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Lonchura.
Aromaticity0.03
Grand average of hydropathy-0.822
Instability index85.66
Isoelectric point9.68
Molecular weight85019.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14180
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     283.91|      36|      36|     209|     244|       1
---------------------------------------------------------------------------
  162-  184 (46.72/ 6.30)	QQQQQQQQFQ..QQQ.......VALQQ.QQ.....QFQ
  209-  244 (73.28/15.51)	QQQQQQQQLQAVQQQ.QQHMLKLQMQQ.QQNQQQMQQQ
  245-  274 (49.63/ 7.31)	Q...QQQQLQRIAQM.QQ....LQAAQvMQAQQQQQQQ
  275-  310 (62.35/11.72)	QQQQQIPQ.QQIQQQpPQQVMQQQMQQ.MQQQQQQQQQ
  311-  340 (51.93/ 8.11)	Q.QQQQQ..Q.VAQA.QQSQLPPQSQP.Q..PQPMVSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.40|      23|      27|     421|     443|       2
---------------------------------------------------------------------------
  341-  360 (31.85/ 6.18)	PQAISGQI...P.......SQVMPVTLTPQ
  410-  431 (40.21/10.01)	SSPSPVQQAQTP........QSMPPPPQPQ
  432-  461 (34.33/ 7.32)	PSPQPGQPTSQPnsnvssgPAPSPSSFLPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.43|      20|     176|     189|     208|       3
---------------------------------------------------------------------------
  119-  139 (25.33/ 7.12)	.MAQQMSLpgQQQPPGTSGMAP
  147-  161 (25.38/ 7.16)	TATQQTQL..QLQQ.....IAQ
  189-  208 (36.73/15.27)	AMQQQFQV..QQQQAAAAAVAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.26|      28|      28|     540|     567|       4
---------------------------------------------------------------------------
  511-  535 (21.27/ 7.56)	.LEKLKQL.......SKYIePLRRMinkiDKNE
  540-  567 (49.67/27.85)	DLSKMKSLLDILTDPSKRC.PLKTL....QKCE
  569-  588 (30.32/14.02)	ALEKLKNDMAVPTPPPPPV.P............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.63|      15|     212|     476|     490|       5
---------------------------------------------------------------------------
  476-  490 (30.02/13.04)	PQNFSVPSPGPLNTP
  698-  712 (28.62/12.02)	PLQLSVPADYPDQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.91|      16|      27|      74|      92|       6
---------------------------------------------------------------------------
   74-   92 (20.77/17.60)	SQASvSDPMNALQNLtgGP
  103-  118 (31.14/14.65)	SRAQ.GAPMSGMTGL..GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.09|      13|      14|     373|     385|       9
---------------------------------------------------------------------------
  373-  385 (20.94/ 8.96)	QQQQQQAAAAAAV
  389-  401 (22.15/10.09)	QAQAAQMGASGQV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14180 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQNLTGGPAAGAPGMAMASRAQGAPMSGMTGLGPMAQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQTQ
2) QVAQAQQSQLPPQSQPQPQPMVSQPQAISGQIPSQVMPVTLTPQQLKAMQVRAQLVQQQQQQAAAAAAVQAAQAQAAQMGASGQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSGQSEEQQYLEKLKQ
70
317
153
516










Molecular Recognition Features






MoRF SequenceStartStop




NANANA