<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14178
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MVLEGLNELLPEPSLLQAEQPELSQPLESCGSSQVIGSIDVMLTDVTNMNDGVVTAISTNALMEQLHLKYQQRPWTETLKLVYFCMDNPHRKPVSNAPDGLLLSCMEKIERTLNAKSMFSVMDILELLARQKGLTVHVSPSGTACYITSMMFYLEIQLEKDGDVMDVKLAHFEEAPVVCDDLVQLLSKMKAKGYLALQALEKDLYSMSLLDRGGLQIDGKQFPKPFGTPMNIEFYISPYQVLEAELNHGSQVCGTKTVVTVEGTDTLHKLPLSPLIIEPQAGEDSYTVYNLWLLRFSQMDFKRIRISGLKLAPLYELIVQSTLKEKCSEDLSINKSCFFVSLPDCSKHCYFINKGSEKSGLAGALVSKIPFSHPKCVPGVIEILRHQVAYNTLISSCVSEKHINEVFLFLDDSELLYFEVVPYKNTSFSVFFLHPVKKNLACGMCRIITTVLFTELTGDLVLSRLLHYASQLQMVIDVTTSREVQCHLHLNPQDPTLNSTDDFIARAVKRCMSIPVVMRAVFRNAAKVKADHETHDTDTEKQPGLQSEQTTDSNSLKESLSGADQQDWVVTDKPNNTDSTEEILFTAKLETLGNNMGKK |
Length | 599 |
Position | Middle |
Organism | Lonchura striata domestica (Bengalese finch) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda>
Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae>
Estrildinae> Lonchura.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.099 |
Instability index | 47.21 |
Isoelectric point | 5.35 |
Molecular weight | 66983.50 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP14178
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 67.59| 22| 528| 12| 34| 4
---------------------------------------------------------------------------
12- 34 (36.83/27.65) EPSlLQAEQPELSQPL.ES.CGSSQ
542- 565 (30.76/17.88) QPG.LQSEQTTDSNSLkESlSGADQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 165.37| 51| 68| 297| 351| 5
---------------------------------------------------------------------------
297- 351 (81.17/69.26) SQMDFKRIR.ISGLkLAPLYELIVQSTLKEKCSEDLSINKSCFFVslpDCSKHCYF
367- 418 (84.19/58.32) SKIPFSHPKcVPGV.IEILRHQVAYNTLISSCVSEKHINEVFLFL...DDSELLYF
---------------------------------------------------------------------------
|