<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14176

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCFVPNGASLEDCHSNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRELWIFWWGDDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEISQHQPVYLLSEEHLTLAQQSNNPFQVILSPFGLNGTLTGQSFKLSDSSTKKLIGEWKQFYPVTSNLKEGSEEKQEEMDWEDDSLAAVEVLVAGVRMVYPACFVLVPQTDIPAPSSVGAPHCSTACLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQKWVKFSSVSDGFISDSTSHHGGKIPRKLANQVVDRVWQECNMNRAQNKRKYSATSNGLCEEETADKVASWDFVEATQRTNCNCSRHKNLKPRNSGQQGQAPPVGPQQPAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLVMAAPDSQVRFANIRTADGAKPPQLHGAELANSPQPPPLSPHPCDGADEGVPKAPSTPQSQHFYQMPTPDPLVPTKAMEDRLDGLSQPFPATFPEVIEPTVYVGTAVNLEEDEADTTWKYYKVPKKKDVEFLPPQLPNDKLRDDPVIPAGQENVTSVTELMVQCRKPLKVSDELVQQYQSKNQYLTAVATEADQEPEIDPYAFVDGDVEFLFPDSKKDRQNIEREVGKKHKAEDGTSSVTVLSHEGEDAMSLFSPSVKQDAQRLAAHARTASTSLFHETDLVVSYTDLDNLFNSDEDELTPGSKRTVNGTDDKSNCKEAKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTLGGTVLEGNSSTVGAQFRIEVDEGFCSPKPAEIKDYSYVYKPENCQALVGCSMFAPLKTLPSQCLPPIKLPEECIYRQSWTVGKLDLLPPGPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNSSGLFLEDELDILGRNTECGKEAEKRFEALRATSIEHGSAGLKEPEKLPDDLILLLQDQCTNLFSPFGAADQDSIAKVGAVSNLVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKTTCLHHWSKRNVVDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDVAYVVVCPENEALLNGAKSFFRDLTAIYESCRLGQHRPICKLLPDGIMRVGPTASKKLSEKLVTEWFSQTANANNDAFSKLKLYAQVCRYELGPYLASQPLDNSLLSQTNLVPPSSQAASALPPVTAPAANPNTPSSAPAAPASSTIAVTSSSSAMSSAATTANSTLTTTAPSSSSASLGSGIPTSKPSSFPPFSNINNTTPASLPTQAAPVPNGQTGGQQQQPTLQTAGMSGDTAAAPAQPHPEVSESTMDRDKVGVPTDGDSHAITYPPAIVVYIIDPFTYEKKDENSSSSSLWTLGLLRCFLEMVQVLPPHIKNIISVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDLYGEQLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASSTYTTENLDLAFNTNNDGADGMGIFDLLDTGDDLDPDIINILPASPGGSPVHSPGSHYPHGGDMGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length2180
PositionMiddle
OrganismLonchura striata domestica (Bengalese finch)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Lonchura.
Aromaticity0.07
Grand average of hydropathy-0.392
Instability index52.39
Isoelectric point5.41
Molecular weight239208.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14176
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.34|      18|      27|    1581|    1606|       1
---------------------------------------------------------------------------
 1581- 1606 (25.92/29.68)	AAPvpngqtggQQQQPTLQTAGMSGD
 1609- 1626 (33.42/17.28)	AAP........AQPHPEVSESTMDRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.39|      23|      27|    1501|    1523|       2
---------------------------------------------------------------------------
 1511- 1540 (27.23/12.45)	PAAPASSTIAVTS.......sssamssAATTANSTLT
 1541- 1577 (28.16/13.17)	TTAPSSSSASLGSgiptskpssfppfsNINNTTPASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.24|      21|      27|     428|     448|       3
---------------------------------------------------------------------------
  428-  448 (36.27/14.72)	RHKNLKPRNSGQQGQAPPVGP
  455-  475 (35.98/14.54)	KHKTNEKQDKGDKPQKRPLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.98|      26|      27|     907|     933|       4
---------------------------------------------------------------------------
  907-  933 (45.21/28.57)	PENC...QA.LVGcSMFAPLKTL.PSQCLPPI
  936-  962 (26.51/ 9.98)	PEECiyrQSwTVG.....KLDLLpPGPAMPFI
  972-  995 (40.27/19.71)	QEYG...PA.YTP.QTHTPF.GM.PPSSAPP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.36|      14|      27|    1839|    1852|       5
---------------------------------------------------------------------------
 1839- 1852 (27.15/19.10)	GSARRLGLQKLWEW
 1869- 1882 (27.21/19.17)	GRLGRIGHGELKDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.31|      28|      28|    1100|    1127|       6
---------------------------------------------------------------------------
 1100- 1127 (51.80/31.79)	CNMNIK.GADVGVYIPDPTQE.....AQYRCTCG
 1130- 1158 (40.79/23.29)	AVMNRKfGNSSGLFLEDELDI.....LGRNTECG
 1169- 1199 (30.73/15.52)	RATSIE.HGSAGLKEPEKLPDdlillLQDQCT..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.41|      20|      27|     553|     572|       7
---------------------------------------------------------------------------
  518-  539 (26.95/11.07)	KPPQlhGAELANSPQPPPLSPH
  553-  572 (37.82/18.92)	STPQ..SQHFYQMPTPDPLVPT
  583-  602 (27.64/11.57)	SQPF..PATFPEVIEPTVYVGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.42|      20|      26|    1224|    1246|       8
---------------------------------------------------------------------------
 1224- 1246 (34.61/30.78)	RVEERDCCNDCylaLEH..GRQFMD
 1252- 1273 (29.82/17.48)	KVDEALVKTTC...LHHwsKRNVVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.74|      22|      27|    1681|    1702|       9
---------------------------------------------------------------------------
 1681- 1702 (38.47/26.02)	QVLPPHIKNIISVQIVPCQYLL
 1711- 1732 (38.28/25.84)	QIYTQHLKSLAFSAFTQCRRPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.18|      21|      27|    1333|    1353|      10
---------------------------------------------------------------------------
 1311- 1333 (24.54/10.18)	PLTWQQFhkMA..GrgsY....GTDE...SPE
 1334- 1354 (40.13/21.39)	PLPIPTF..LL..G...Y....DYDFLVLSPF
 1355- 1380 (22.51/ 8.72)	ALPYWER..LMleP...YgsqrDVAYVVVCP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.27|      12|      40|    1003|    1014|      11
---------------------------------------------------------------------------
 1003- 1014 (26.93/11.80)	LPSP.STPRFPTP
 1043- 1055 (22.34/ 8.39)	LYSPaSTPSTCRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.03|      25|      40|    1413|    1437|      12
---------------------------------------------------------------------------
 1413- 1437 (42.59/29.71)	KL.LPDGIMR..VGP.TASKKLSEKLVTE
 1452- 1480 (30.44/18.56)	KLkLYAQVCRyeLGPyLASQPLDNSLLSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     243.07|      75|     259|      46|     133|      15
---------------------------------------------------------------------------
   46-  133 (111.86/108.86)	PVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRelWIfwwgddpNFADLIHHDLSeeeDGVWENGLSYEcRTLLFKAVHNLLERCLMN
  312-  386 (131.21/85.89)	PASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQK..WV.......KFSSVSDGFIS...DSTSHHGGKIP.RKLANQVVDRVWQECNMN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14176 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
2) GSPVHSPGSHYPHGGDMGKGQGTDRLLSTESH
3) NCNCSRHKNLKPRNSGQQGQAPPVGPQQPAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLVMAAPDSQVRFANIRTADGAKPPQLHGAELANSPQPPPLSPHPCDGADEGVPKAPSTPQSQHFYQMPTPDPLVPTKAMEDRLDGLSQPFP
4) VPPSSQAASALPPVTAPAANPNTPSSAPAAPASSTIAVTSSSSAMSSAATTANSTLTTTAPSSSSASLGSGIPTSKPSSFPPFSNINNTTPASLPTQAAPVPNGQTGGQQQQPTLQTAGMSGDTAAAPAQPHPEVSESTMDRDKVGVPTDGD
956
2027
423
1484
1041
2058
587
1635










Molecular Recognition Features






MoRF SequenceStartStop




NANANA