<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14171

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAAPGSAEEAEKLNKMSSLLERLHAKYSQNRPWTETIKLVRQVMEKRVVLNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQSGLGSHLSANGTECYITSDMFYVEVQLDPAGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLQKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVVLHENSVPRSLGMNVSVTVEGTMAMHKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQSCTGIPLFDTAPTFVPLYELITQFELSKEADPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSSHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPATYPQALPHAQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPTSTEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNSSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYGPQALTNLGVQVLGADGGENKFKGSAPSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSAMAGAGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSKSEGSSGSKMSSSLYSSQGGSGSGQSKGSAQSVGKPGSSPITKHGLSTGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPIGSGSGGSHMSGAGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKNSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSAEKHKKHKKEKKKVKDKDRDRERERDKDRDKKKSHGVKPESWSKSPISADQSLSMASNAILSAERPSRASPEFLIGEEDDDLMDVALIGN
Length1582
PositionMiddle
OrganismLonchura striata domestica (Bengalese finch)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Lonchura.
Aromaticity0.04
Grand average of hydropathy-0.626
Instability index54.85
Isoelectric point8.88
Molecular weight167569.55
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14171
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1147.43|     184|     184|    1101|    1284|       1
---------------------------------------------------------------------------
  577-  728 (178.27/40.48)	FNMS.....IS...MKERHDSVGHGEDFS...KVSQNPILTSllQITGNVGST..IGS.S.PT.PPHHTPPP.VSSPASNTKN.HPM...LMNL..LKENPP.......QDFSTL.YGSS....PLerqnSSSGS................................................PRMEMGPGGN.K....Q.....KKKKSRMPADKPKH...Q....T.EDD...FQRELFS..MDVDS.Q..npifDVNM
  729-  927 (204.50/47.53)	TADT.....LDTPHITPA...PSQCSTPP...ATYPQALPHA..QPSIQRMVR..LSS.SdSI.GPDVTDIL.SDIAEEASK..LPT...S.....TEDCPPigtpvrdSSSSGH.SQSA....LF....DPDVFQTNSSENpytdPADLIADAAVSPNS.........DSSNHfFPDGVDFNPDLLNSQSQSGF....GeeyfdESSQSGDTDDFKGY...GPqaLT.NLGvqvLGADGGE..NKFKG.SA.....PSDT
  928- 1075 (172.59/38.95)	VDFS..........IIAAASKALGSSDIMehhSGGQSPLLNT..GDLGKEKSQkrVKE.G.NGsGSAMAGAGiDGKPGKRSRT.PSS...DGKS..KEKLPK.......RKKQETdGKSP....SH....SSSNRPFT..............PPASTG...........GSKSP.GSSG........RSQTPPG...................VATP......P..IP.KIT...IQIPKGT..VTV....GK....P...
 1076- 1180 (135.78/29.05)	...............................................................................SSHGqYTS...SGSV..T....................S............SSSKSHHSHS.S....SSSSSSSSSTSGKI.........KSKSE.GSSGSKMSSSLYSSQGGSGS....G.....QSKGSAQSVGKPGS...SP..IT.KHG...LSTGSGS..TKMKP.QGK....PSSL
 1181- 1363 (275.16/66.53)	MNPS.....MSKPNISPSHSRPSGGSDKL...ASPMKPVPGT..PPSSKAKSP..IGS.G.SG.GSHMSGAG.SSSSMKSSSG.MGS...SGSM..SQKPPP.......SSNSST.ASSS....SF....SSSGSSMSSSQN....QHGSSKGKSPS.RN.........KKPSL.TAVIDKLKHGVVTS.GPGGDdpmdG.....QMGPSSNSSSHTMS...S......KHN...MSGGEFQ..GKREK.SDK....EKSK
 1364- 1566 (181.12/41.24)	VSVSggsvdSSKKN.SDSKNVGSTGVAKI...I..ISKHDGG..SPSIKAKVT..LQKpG.EG.G....GDG.LRPQMASSKS.YGSpliSGSTpkHERCSP.......SHSKSP.AYTPqnidSE....SESGSSI....A...eKSYQNSPSSDDG.IrplpeysaeKHKKH.KKEKKKVKDKDRDRERERDK....D.....RDKKKSHGV.KPESwskSP..ISaDQS...LSMASNAilSAERPsRAS....PEFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.41|      20|      72|     303|     322|       2
---------------------------------------------------------------------------
  303-  322 (37.18/24.64)	CFFLKFPRPIPVSRA....FIQKL
  374-  397 (29.23/17.49)	CYFLNKDAPLPDGRSlqgtLISKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.49|      65|      72|       5|      71|       3
---------------------------------------------------------------------------
    5-   71 (99.81/73.56)	PGSAEEAEKLNKMSSLLERLHAK....YSQNRPWTETIKLVRQVMEKRVVLNSGGHQHlVSCLEtLQKALK
   76-  144 (106.68/69.81)	PAMTDRLESIARQSGLGSHLSANgtecYITSDMFYVEVQLDPAGLLCDVKVAHHGENP.VSCPE.LVQHLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.90|      14|      30|     239|     253|       5
---------------------------------------------------------------------------
  239-  253 (20.85/14.23)	APVVLHENSVPrSLG
  272-  285 (26.05/13.13)	APLIMGSHPVD.SKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.12|      20|      22|     534|     553|       6
---------------------------------------------------------------------------
  534-  553 (35.75/18.77)	EDMVKKNLPPASSPGYGMTT
  556-  575 (36.37/19.25)	NPMSGTTTPTNTFPGGPITT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14171 with Med1 domain of Kingdom Metazoa
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