Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAAPGSAEEAEKLNKMSSLLERLHAKYSQNRPWTETIKLVRQVMEKRVVLNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQSGLGSHLSANGTECYITSDMFYVEVQLDPAGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLQKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVVLHENSVPRSLGMNVSVTVEGTMAMHKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQSCTGIPLFDTAPTFVPLYELITQFELSKEADPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSSHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPATYPQALPHAQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPTSTEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNSSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYGPQALTNLGVQVLGADGGENKFKGSAPSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSAMAGAGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSKSEGSSGSKMSSSLYSSQGGSGSGQSKGSAQSVGKPGSSPITKHGLSTGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPIGSGSGGSHMSGAGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKNSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSAEKHKKHKKEKKKVKDKDRDRERERDKDRDKKKSHGVKPESWSKSPISADQSLSMASNAILSAERPSRASPEFLIGEEDDDLMDVALIGN |
Length | 1582 |
Position | Middle |
Organism | Lonchura striata domestica (Bengalese finch) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Lonchura. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.626 |
Instability index | 54.85 |
Isoelectric point | 8.88 |
Molecular weight | 167569.55 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl nucleolus GO:0005730 IEA:Ensembl nucleoplasm GO:0005654 IEA:Ensembl |
GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl estrogen receptor binding GO:0030331 IEA:Ensembl LBD domain binding GO:0050693 IEA:Ensembl nuclear receptor coactivator activity GO:0030374 IEA:Ensembl peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl promoter-specific chromatin binding GO:1990841 IEA:Ensembl protein-containing complex binding GO:0044877 IEA:Ensembl retinoic acid receptor binding GO:0042974 IEA:Ensembl thyroid hormone receptor binding GO:0046966 IEA:Ensembl transcription corepressor activity GO:0003714 IEA:Ensembl vitamin D receptor binding GO:0042809 IEA:Ensembl |
GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl angiogenesis GO:0001525 IEA:Ensembl animal organ regeneration GO:0031100 IEA:Ensembl brain development GO:0007420 IEA:Ensembl cell morphogenesis GO:0000902 IEA:Ensembl cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl embryonic heart tube development GO:0035050 IEA:Ensembl embryonic hemopoiesis GO:0035162 IEA:Ensembl embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl enucleate erythrocyte development GO:0048822 IEA:Ensembl fat cell differentiation GO:0045444 IEA:Ensembl intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl keratinocyte differentiation GO:0030216 IEA:Ensembl lens development in camera-type eye GO:0002088 IEA:Ensembl liver development GO:0001889 IEA:Ensembl megakaryocyte development GO:0035855 IEA:Ensembl monocyte differentiation GO:0030224 IEA:Ensembl mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl negative regulation of apoptotic process GO:0043066 IEA:Ensembl negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl negative regulation of neuron differentiation GO:0045665 IEA:Ensembl negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl positive regulation of gene expression GO:0010628 IEA:Ensembl positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl protein import into nucleus GO:0006606 IEA:Ensembl regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl retinal pigment epithelium development GO:0003406 IEA:Ensembl thyroid hormone generation GO:0006590 IEA:Ensembl thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP14171 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 6| 1147.43| 184| 184| 1101| 1284| 1 --------------------------------------------------------------------------- 577- 728 (178.27/40.48) FNMS.....IS...MKERHDSVGHGEDFS...KVSQNPILTSllQITGNVGST..IGS.S.PT.PPHHTPPP.VSSPASNTKN.HPM...LMNL..LKENPP.......QDFSTL.YGSS....PLerqnSSSGS................................................PRMEMGPGGN.K....Q.....KKKKSRMPADKPKH...Q....T.EDD...FQRELFS..MDVDS.Q..npifDVNM 729- 927 (204.50/47.53) TADT.....LDTPHITPA...PSQCSTPP...ATYPQALPHA..QPSIQRMVR..LSS.SdSI.GPDVTDIL.SDIAEEASK..LPT...S.....TEDCPPigtpvrdSSSSGH.SQSA....LF....DPDVFQTNSSENpytdPADLIADAAVSPNS.........DSSNHfFPDGVDFNPDLLNSQSQSGF....GeeyfdESSQSGDTDDFKGY...GPqaLT.NLGvqvLGADGGE..NKFKG.SA.....PSDT 928- 1075 (172.59/38.95) VDFS..........IIAAASKALGSSDIMehhSGGQSPLLNT..GDLGKEKSQkrVKE.G.NGsGSAMAGAGiDGKPGKRSRT.PSS...DGKS..KEKLPK.......RKKQETdGKSP....SH....SSSNRPFT..............PPASTG...........GSKSP.GSSG........RSQTPPG...................VATP......P..IP.KIT...IQIPKGT..VTV....GK....P... 1076- 1180 (135.78/29.05) ...............................................................................SSHGqYTS...SGSV..T....................S............SSSKSHHSHS.S....SSSSSSSSSTSGKI.........KSKSE.GSSGSKMSSSLYSSQGGSGS....G.....QSKGSAQSVGKPGS...SP..IT.KHG...LSTGSGS..TKMKP.QGK....PSSL 1181- 1363 (275.16/66.53) MNPS.....MSKPNISPSHSRPSGGSDKL...ASPMKPVPGT..PPSSKAKSP..IGS.G.SG.GSHMSGAG.SSSSMKSSSG.MGS...SGSM..SQKPPP.......SSNSST.ASSS....SF....SSSGSSMSSSQN....QHGSSKGKSPS.RN.........KKPSL.TAVIDKLKHGVVTS.GPGGDdpmdG.....QMGPSSNSSSHTMS...S......KHN...MSGGEFQ..GKREK.SDK....EKSK 1364- 1566 (181.12/41.24) VSVSggsvdSSKKN.SDSKNVGSTGVAKI...I..ISKHDGG..SPSIKAKVT..LQKpG.EG.G....GDG.LRPQMASSKS.YGSpliSGSTpkHERCSP.......SHSKSP.AYTPqnidSE....SESGSSI....A...eKSYQNSPSSDDG.IrplpeysaeKHKKH.KKEKKKVKDKDRDRERERDK....D.....RDKKKSHGV.KPESwskSP..ISaDQS...LSMASNAilSAERPsRAS....PEFL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 66.41| 20| 72| 303| 322| 2 --------------------------------------------------------------------------- 303- 322 (37.18/24.64) CFFLKFPRPIPVSRA....FIQKL 374- 397 (29.23/17.49) CYFLNKDAPLPDGRSlqgtLISKI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 206.49| 65| 72| 5| 71| 3 --------------------------------------------------------------------------- 5- 71 (99.81/73.56) PGSAEEAEKLNKMSSLLERLHAK....YSQNRPWTETIKLVRQVMEKRVVLNSGGHQHlVSCLEtLQKALK 76- 144 (106.68/69.81) PAMTDRLESIARQSGLGSHLSANgtecYITSDMFYVEVQLDPAGLLCDVKVAHHGENP.VSCPE.LVQHLR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 46.90| 14| 30| 239| 253| 5 --------------------------------------------------------------------------- 239- 253 (20.85/14.23) APVVLHENSVPrSLG 272- 285 (26.05/13.13) APLIMGSHPVD.SKG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.12| 20| 22| 534| 553| 6 --------------------------------------------------------------------------- 534- 553 (35.75/18.77) EDMVKKNLPPASSPGYGMTT 556- 575 (36.37/19.25) NPMSGTTTPTNTFPGGPITT --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYFD 2) IPKITIQIPKGT 3) IRPLPEYSAEKHKKHKKEKKKVKDKDRDRE 4) MSSSL 5) NKKPSLTAVIDKLKHGVV 6) SIKAKVTLQK 7) SPEFLIGEEDDDLMDVALIGN 8) VAKIIISKH 9) YGSPLI | 877 1058 1485 1126 1297 1402 1562 1388 1430 | 883 1069 1514 1130 1314 1411 1582 1396 1435 |
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