<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14168

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGVLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINNWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFIVLTANLFSPEWTQIITKYLSEQLQKIAEFYRQLPGQGCGSTSGPMPQEVEQALKQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRSGEDEFLKMLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLAMQLDGAGGHPPHILSAQTGNALPSTPTPQPAAGNPPPSPFSDLLLCPQHRPVVYGLSCILQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGLGPTKDSHEISPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSISSGSLSAASAPVFQDVLMQFLDTQAPMLTDPGKENEKVEFFNLVLLFCELIRHDVFSHNIYMCTLISRGDLAMDSHGPRPPSPFDDAAEEHDRKETEGSSGIKLEDTGLSEPMDIDHNPSMLFDDMEKTDFSMFSPPMHCESKASPSPEKPDPEKEAKTLLKDKSVEGMLASLYDQPRHIQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHTIKKITKDILKVLNRKSTAETGGEEGQKRKKSKPEAFPTAEDIFAKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPEFMIDTIENPSAHNFTYTNLGKSLNENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHPGGVDDLMDDELGTRKAGGRVVTVETASLDIYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTASNEMNSLLENIAKATIEVFQQSAETSSASCTGNGVNNISSSTSATPASNKSKPILSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRKVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVALEPEKKTAEPAKADKTSSNPAASTEERKKKQSKTKKRNQSASKTEDFVLGPSRGVSYGVGMPTDLLHHQSGSTMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSGVLPPGMGSMMGIDPSYKPAVYRQQPPVSQGQILRQQLQAKLQGQGIMGQQPVRQMAPTPSYGALQPSQGYTPYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLTNTQRFPHQSIQQTPMMSGMNHLGPQGVPSGIRPSQILPDQQQQQYLRQQQQQQMLREGCHSVGGCLCSSSNSSSSNNSNSSNSSSSPSHRSPSPSSSPRCPQCLSPRRRASPQGWGCRLFPPSSPFSSARAFSRHSSSSKQLLWFDSFSSSFPIHRHSRTTTHLDATDLWHFSLIQEGETSLWMDTASSA
Length2152
PositionKinase
OrganismLonchura striata domestica (Bengalese finch)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Lonchura.
Aromaticity0.07
Grand average of hydropathy-0.442
Instability index54.64
Isoelectric point6.92
Molecular weight239670.46
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14168
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     524.71|     166|     553|     416|     637|       1
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  416-  591 (262.10/167.90)	LHTLEVLDSHSFERSDFSNSL.DSLYNRI.F...GLGPTKDSHEiSPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQaeiEAERCGDSEVVDEKGSIS.SGSLSAASAPVF..QDVLMQFLDTQA..PMLTDPGKENEKVEffNLVLLFCELIRHDVFSHNIYMCtlisRGDLAMDSHGPR
  966- 1141 (262.61/144.57)	IDTIENPSAHNFTYTNLGKSLnENPANRYsFvcnALMHVCVGHH.DPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSS...NNGTCGFNDLLCNVSDLSfHDSLATFVAILIarQCLLLEDLIRCAaiPSLLNAACSEQDSE..PGARLTCRILLHLFKTPQLNPC....QQDGNKPTVGIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.81|      19|      19|    1891|    1909|       2
---------------------------------------------------------------------------
 1891- 1909 (37.82/19.91)	PSQGY......TP.....YVSHI.GLQQHPS
 1923- 1947 (24.89/10.51)	PYQNS......HPssnpaLVDPVrQMQQRPS
 1953- 1976 (22.10/ 8.48)	QAPGYghtltnTQ.....RFPHQ.SIQQTP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.94|      14|      18|    1606|    1623|       3
---------------------------------------------------------------------------
 1606- 1623 (13.23/23.56)	TKgNKIAGFDsIFkkEGL
 1627- 1640 (28.71/18.70)	TK.QKISPWD.LF..EGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.45|      25|     210|    1772|    1796|       5
---------------------------------------------------------------------------
 1770- 1794 (44.42/23.65)	HQSGSTMSRLAYG..QSPVGLYAQNQP
 1795- 1821 (37.03/18.40)	LPAGGPRLDTSYRpvRMPLGKLVQSRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.30|      19|     553|     615|     637|       6
---------------------------------------------------------------------------
  615-  637 (29.96/25.52)	KLEDTGLSEPMDIDHnpsmLFDD
 1175- 1193 (36.34/19.72)	ELKGSGFSHPGGVDD....LMDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.90|      30|     553|    1455|    1488|       7
---------------------------------------------------------------------------
 1455- 1488 (48.60/39.81)	QIVTNWREDQYQDDCKAKQLMHEAlklrLNLVGG
 1997- 2026 (55.30/35.55)	QILPDQQQQQYLRQQQQQQMLREG....CHSVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.39|      13|      61|    2031|    2043|      11
---------------------------------------------------------------------------
 2031- 2043 (21.52/10.12)	SSNSSSSNNSNSS
 2050- 2062 (23.34/11.72)	SHRSPSPSSSPRC
 2089- 2101 (20.52/ 9.24)	SSARAFSRHSSSS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14168 with Med12 domain of Kingdom Metazoa
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