Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MAAVDIRDNLLGISWVDSSWIPILNNGSVLDYFSERSNPFYDRTCNNEVVKMQRMTLDHLNQMVGVEYILLHAQEPILFIIRKQQRQSPTQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFEEAMSYCRYHPSKGYWWHFKDEEEREKTKPKAKKKEEPSSIFQRQRVDALLLDLRQKFPPRFVQQKPGEKPIPVDQIKKEPEPVPEAVKTEEKETVKNAQSAGAKGPPEKRMRLQ |
Length | 245 |
Position | Head |
Organism | Lonchura striata domestica (Bengalese finch) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Lonchura. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.607 |
Instability index | 49.34 |
Isoelectric point | 8.69 |
Molecular weight | 28290.12 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 PIRNR:PIRNR023869 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl nucleoplasm GO:0005654 IEA:Ensembl |
GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro stem cell population maintenance GO:0019827 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP14165 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 82.51| 24| 41| 148| 171| 1 --------------------------------------------------------------------------- 148- 171 (39.95/23.06) HFKDEEEREKTKPKAKKKEEPSSI 191- 214 (42.56/24.99) RFVQQKPGEKPIPVDQIKKEPEPV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AGAKGPPEKRMRLQ 2) EKPIPVDQIKKEPEPVPEAVKTEEKETVKNAQ 3) IFQRQRVDALLLDLRQKFPPRFVQQ | 232 199 171 | 245 230 195 |
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