<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14161

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMTAAPAPSPQQIRDRLLQAIDPQSNIHNMVAVLEVISSLEKYPITKEALEETRLGRLINEVRKKTSNEELAKRAKKLLRNWQKLIEPVTQNEPVPRGLPNPPGSANGGAHNCKPDSQLPAVPGAKPISELKSRNDIQKLNSPKAEKLGNRKRKGDHRDGHQGPPPAKVSKASHEVLQNSSPPPTNGIGGSPENFPSPVDINLHAGPESSRTDLSENDKHNKIPVNAVKPHTSSPGLVKPSSTSSLLKTAVLQQHDKSEEATGPHQPKSPRCSSFSPRNVRHDTFARQHTTYSPKDSMPSPSQRSQFADAAPVPSPPPSLMQPSSPPVPAKRLEFPPQAAPEAAQHWQEQQGAPEGQHRHTAGTLQQHTAPGCKAHPGESHVGFPQDTSRMDSDDAASGSDSKKKKRYRPRDYTVNLDGHVIEGGVKPVRLKERKLTFDPMTGQIKPLTPKDPLQVEIPALTEQHRTETEKQEQKPNLQSPFEQTNWKELSRNEIIQSYLNRQSSLLSSSGVQTPGAHYFMSEYLKQEESTRKEARKTHVLAPNSKPTDLPGVTREVTGDDLDRIRDHNWPGVNGCYDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length609
PositionUnknown
OrganismLonchura striata domestica (Bengalese finch)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Lonchura.
Aromaticity0.04
Grand average of hydropathy-0.991
Instability index64.40
Isoelectric point8.93
Molecular weight67237.29
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14161
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.59|      14|      23|     264|     285|       1
---------------------------------------------------------------------------
  264-  277 (28.16/ 7.02)	HQPKSPRCSSFSPR
  288-  301 (26.44/17.55)	HTTYSPKDSMPSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.10|      12|      15|     163|     174|       4
---------------------------------------------------------------------------
  163-  174 (22.10/ 9.23)	PPPAKVSKASHE
  181-  192 (23.00/ 9.89)	PPPTNGIGGSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.29|      18|      22|     423|     443|       5
---------------------------------------------------------------------------
  426-  443 (31.45/25.98)	KPVRLKER.KLTFDPMTGQ
  445-  463 (26.83/11.37)	KPLTPKDPlQVEIPALTEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.03|      12|      82|     229|     241|       6
---------------------------------------------------------------------------
  229-  241 (18.63/10.29)	PhTSSPGLVKPSS
  313-  324 (25.40/10.22)	P.SPPPSLMQPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.67|      14|     137|     335|     348|       7
---------------------------------------------------------------------------
  335-  348 (27.17/13.27)	PPQAAPEAAQHWQE
  365-  378 (27.50/13.52)	QQHTAPGCKAHPGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.83|      36|      76|      37|      76|       8
---------------------------------------------------------------------------
   37-   76 (45.13/42.26)	SSLEKYPITKeALEETRlGRliNEVRKKTS..NEELAKRAKK
  116-  153 (55.70/35.16)	SQLPAVPGAK.PISELK.SR..NDIQKLNSpkAEKLGNRKRK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14161 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NWQKLIEPVTQNEPVPRGLPNPPGSANGGAHNCKPDSQLPAVPGAKPISELKSRNDIQKLNSPKAEKLGNRKRKGDHRDGHQGPPPAKVSKASHEVLQNSSPPPTNGIGGSPENFPSPVDINLHAGPESSRTDLSENDKHNKIPVNAVKPHTSSPGLVKPSSTSSLLKTAVLQQHDKSEEATGPHQPKSPRCSSFSPRNVRHDTFARQHTTYSPKDSMPSPSQRSQFADAAPVPSPPPSLMQPSSPPVPAKRLEFPPQAAPEAAQHWQEQQGAPEGQHRHTAGTLQQHTAPGCKAHPGESHVGFPQDTSRMDSDDAASGSDSKKKKRYRPRDYTVNLDGHVIEGGVKPVRLKERKLTFDPMTGQIKPLTPKDPLQVEIPALTEQHRTETEKQEQKPNLQSPFEQTNW
2) TRKEARKTHVLAPNSKPTDLPGVTREVTGDDLDRI
80
530
486
564










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRLEFP
2) IRDRLL
3) KKKKRYRPRDY
329
12
402
335
17
412