<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14157

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMATVKGQLDKSKELQKEILMEKLRSKTSQYKNLSETSKAVRMALLDKRWAVDNADRMILQKCLDSLQHCIKVSSLQSLIERLECLSRQLGLKFVVGTSGVNLFISSDMFYLEILVESSGSVKDVKIHHEGKIEQQSCEELVQCISRGDFADFTAQLEGLTAVYQLNAEKKVKCKAFSALQSLEEDLCTLRQLQSFIKDPWAQVHKSPIGFLQRRRGGHALRLTYFVSPYELLDKEKGLQPLTVDLLTSGKPSSSSGLASLVSPSHTPIGHSATVLLEGSAANKLQLSPIIAGGQRPGKGNGPVYAQLVPQNSAMLPACFTLKLSQPTPMCAGLAKLIHATTDVEVAGDWANAKPMLGLVAQQAYNKLAPGKTVELNLSKGLFVSLPEQWQCYFLCETRGLDGCMVTSVPFTHPSHVPPLLSVLRQQALFNALLASCVRLQTKQVMELESVLMFEVSALSWQHISISLEHPVDESMATVELDLADPAAPRASLYTLNSPPRDHIDDYITKVLQKSHSIPVTLRSLIKIWERERATKQINGSYSALESNFSCGLGGIDPGGDVKHEPGSMHGRAMYPANVSHPHQGGTYLSEQQHHLSMMCQDNPSDLKPAGSEERKSKKRKVEPGLWPSGQKKGKPGMNDMMDSDSESDNSDGYGNEDDTMNSNSTNDDIEGPSSVSQNEFASDLELYGMDTPDALGGQENRTSSDMDNSNDGDVEDIIRNSFHKSEHKRQKLKSKDSESRRSTSSLLLDLTEGKSYMPSSVSITPIGSTSSNPPSSGSGSNISSMLCLDRRPGIEIIPITAAPPAALPSSITITPITSSQIKSLDDRMRSDKKSSRSGEERSKEKKKKRRRDDSMGPPEKIPPKQDPLTKPVSVSIKPTDGSPMRPTSPNSILRKFSPSPTQGRSVSISKSPSPSSVKGMGKPSGTSSHHSSPRHSPVQNSPKHLTGYSSPKNHSISSPKHSSSGSGKPSMSTLKSATSGSPSGKSSATGYDLSKKLSKESYGSSSATSRDKEKKHSSLSFSSSDRSSPKLKNPMKLKQLEITPVSCDSPVTEPLISPSNIEVNKSNAPSQARNRKGSLSAVIDKLKSAQHCGAESEITIKSSSSSSSKFSDPKSSSSNVKINESKNQEYMVKPSLDGMKITINKTRSKESSSSSSKLNYSSSSSSKQSSPQLTPPSQGSPKTHTGLKPGVISGPASKKTQVMQSSKSASIASGSTPTKANLSPSEQSGSNSNNTQKVPYTKSSSSSTGINLSSKSVSKSSGSPKSTSSDLAKIMKEREKARTKFLSNSEKSIFTSKSERHSSPSSSRDDVDGDRFKNSKDANFLVEGLMKPLDTSKFQIPKLKNQNTPDKNSPVSQYDSRSMVNDFSRSVDQSKYPFPHYDNSNRNIDTMQKSVYPLNVPKPLLNMGGISPKTIVAGKSDQSEYSKAMSDSIAKGESPQRIKDEVKEGYSGAYPLMPLDFKTDMAKGFPAPKGSSEDRKGADSCMKPPASGTVARSGATTPQEAAEMLLDFSSSSGSKVSGVVSVRPVYPASPALLQLAKSPASSPLVAPSPHSNSPCITDDELMDEALVGPGK
Length1575
PositionMiddle
OrganismDanaus plexippus plexippus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Nymphalidae> Danainae> Danaini> Danaina> Danaus> Danaus.
Aromaticity0.04
Grand average of hydropathy-0.634
Instability index61.56
Isoelectric point9.22
Molecular weight169722.24
Publications
PubMed=22118469

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14157
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1173.36|     226|     226|     849|    1074|       1
---------------------------------------------------------------------------
  555-  727 (239.67/78.37)	ID.PGGDVKHEPGSM........H.GRA...MYPANVSHPH......Q.GGTYLS.EQ.........QHHLSMMC.....Q...DNPSDLK....PAGSEERKSKKRKV.EPGLWP...SGQ........K................KGK.PGMNDM...MDSDSESDN..........SD..GYG.....NEDDTMNSNSTNDD.....IEG.....................P.SSVSQNefASD.........LELYGMD.TP.........DAL.GGQENRTS...SDMDnSND...GDVE......DI..IRN....sfHK...............SEH
  728-  860 (150.39/46.17)	....KRQKL...........KSKD.SES...RRSTS..SLLldltegK.SYMPS...............SVSITPigstsS...NPPSS....GSGSNISSMLCLDRRP.GIEIIP..IT..................AAP.....PAAL.PSSITIT.PITS................SQIKSLDDRMRSDKKSSRSGEERSKE.....KKK.....................K...........................................................................................rrRDDSM......GPPEK
  861- 1097 (372.48/126.26)	IP.PKQDPLTKPVSV...SIKPTD.GSP...MRPTSPNSIL......R.KFSPSP.TQ.........GRSVSISK.....S...PSPSSVKGMGKPSGTSSHHSSPRHS.PVQNSPKHLTGY........SSPKNHSISSPKHSSSGSGK.PSMSTLK.SATSGSPSGK..........SSATGYDLSKKLSKESYGSSSATSRD.....KEK.....................KHSSLSFS..SSDRSSPKLKNPMKLKQLEITPVS......CDSP.VTEPLISP...SNIE.VNK...SNAP......SQ..ARN.rkgslSA..VIDKLksaqhcGAESE
 1098- 1375 (208.34/67.07)	IT.IKSSS.....SS...SSKFSD.........PKSSSSNV........KINESK.NQeymvkpsldGMKITINK.....TrskESSSSSSKLNYSSSSSSKQSSPQLTpPSQGSPKTHTGLkpgvisgpASKKTQVMQSSKSASIASGStPTKANLSpSEQSGSNSNNtqkvpytkssSSSTGINLSSKSVSKSSGSPKSTSSDlakimKERekartkflsnseksiftskseRHSSPSSS..RDDVDGDRFKN............S......KDANfLVEGLMKPldtSKFQ.IPKlknQNTPdknspvSQydSRSmvndfsRS..VDQS...........K
 1376- 1558 (202.48/64.96)	YPfPHYDNSNRNIDTmqkSVYPLNvPKPllnMGGISPKTIV......AgKSDQSEySK.........AMSDSIAK.....G...ESPQRIKDEVK.EGYSGAY..PLM..PLDFKTDMAKGF........PAPKGSS.EDRKGADSCMKP.PASGTVA.RSGATTP............................................QEA.....................AEMLLDFS..SS..SGSKVSGVVSVR..PVYPASpallqlAKSP.ASSPLVAP...S.....PH...SNSP.......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.77|      31|     227|       8|      38|       2
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    8-   38 (50.01/28.59)	LDKSKELQK...EILMEKLRSKTSQYKNLSETSK
  232-  265 (46.76/26.15)	LDKEKGLQPltvDLLTSGKPSSSSGLASLVSPSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.72|      47|      70|     366|     413|       4
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  366-  413 (81.03/55.98)	KLAPGKTVELNlSKGLFVSLPEQWQCYFLCETRGLDGCMVT.SVPFTHP
  438-  485 (73.69/46.29)	RLQTKQVMELE.SVLMFEVSALSWQHISISLEHPVDESMATvELDLADP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14157 with Med1 domain of Kingdom Metazoa
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