<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14156

Description Mediator of RNA polymerase 2 transcription subunit 14
SequenceMQPGKRKLSGSNGRSVRVRQPAYFLPELAHVVAAADERVPFVNLAQELAARGVTHGGVQAEWSGSALGMRIVSLPRPEGASSEAAAALRTRLLAATVRLTTKNQARVWTAEIVFHGSPVPTPNPKEQGERRCVYLQYELGTDAGRTADAFLADWASIVHLHTLLHDFMLRPLQERESVWQGVCIRSYTYRSLVLGFGPAHRATAVLQWSATNQRYTVATPAHQPAANAHHLLHHHLDHYLNWHKDLMSLGVVLRETYMPLLALGRLPTLPQLGLHHIRALMPTPTFTLLAHSWRKIRIIYAGAYSIEVGIRGGNTVTIRDGSYSKFDRCSVVDEFAPAQGLKTFLSRYVDDNISARLLAEDDNPPSPMSPMPPGGLRFPAPLTPPQPHTPHSAPVTPHPASPAQHQMGGGSFNLTSPPGGAGGSGGGSAGGAGVSASPASPMAPSPLAPVASPHPPPTSPFTAWPASPSLPRPSPGHHPSPRHHIEHKAGPQASSSTAVRSGWRSGLSPGTPLAVGKLEALCTPSEPPPGAPPGPPLAPLQRFLACQYMKRTLQRFVHQEEFLTLVSVDALSLTFRCEGAGLAARVALHPQHMQSLHLQLTPLPDHKDNWSADDLQVMEKFFDVRVAIAPYRATALQGWGRAWGAPGAALPSLVALMRAELVPVAPALWTLQWALRIPPAGPQIVPAGQPAVLLAKHKILFFICLTRGDTQLVLPLVYDMQSNVIQIAERRDAQQPHLIAVNLHLKRFAEFNQSHGECILWPAVRDLLINFTLPQDAPAPTAAPPT
Length786
PositionTail
OrganismDanaus plexippus plexippus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Nymphalidae> Danainae> Danaini> Danaina> Danaus> Danaus.
Aromaticity0.07
Grand average of hydropathy-0.143
Instability index58.80
Isoelectric point9.52
Molecular weight84863.39
Publications
PubMed=22118469

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14156
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.83|      16|      16|     396|     411|       1
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  378-  393 (27.06/ 6.33)	FPAPLTPPQPHTPHSA
  396-  411 (30.77/ 8.19)	TPHPASPAQHQMGGGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.72|      34|      70|     419|     471|       2
---------------------------------------------------------------------------
  433-  471 (55.71/38.15)	GVsaSPASPMAPSPLAPVASPHPPPtsPfTAWPASPSLP
  506-  539 (62.02/15.32)	GL..SPGTPLAVGKLEALCTPSEPP..P.GAPPGPPLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.02|      41|      54|     114|     154|       3
---------------------------------------------------------------------------
   72-  108 (40.11/18.95)	.....VSLPRPEGASSEAAA....ALRTRLLAATVRlTTKNQARVW
  114-  154 (73.57/40.78)	FHGSPVPTPNPKEQGERRCV....YLQYELGTDAGR.TADAFLADW
  167-  208 (58.34/30.84)	FMLRPLQERESVWQG..VCIrsytYRSLVLGFGPAH.RATAVL.QW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.96|      25|     148|     582|     633|       5
---------------------------------------------------------------------------
  221-  245 (51.29/16.51)	AHQPAANAHHL..LHHHL....DHYLNWHKD
  583-  613 (37.66/48.74)	AARVALHPQHMqsLHLQLtplpDHKDNWSAD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14156 with Med14 domain of Kingdom Metazoa
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