<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14155
Description |
Mediator of RNA polymerase 2 transcription subunit 14 isoform 1 |
Sequence | MVPVAIEGCNQGTEGGGPRGGSISLGLLIDFIVQRTYDELTVLAELLPRKTDMERKIEIYKFSARTRQLFVRLLALVKWASSATKVDRSAHIMAFLDKQALLFVETADVLARVARETLVHARLPTFHMAAAVEVLTLGTYSRLPAVIRERLVPPPPLTPAERRSTLRALAHVVRQRLTTASLPSDVRNLKVENGRATFTVGQEFSVSLTVMGDAPNVPWRLLDIAILIQDNETGEGKPLVHTSQLNWLRGVAQARLAAAGLSGALTALRFFCRSLSLELLYTQTLRLCRDRLARHLQVDRYIPGQKLQVSYWRELGCELGYRLIVGAEGESLCVWHVPALAGGERVAAALTPHAPSMERLLAHTVHVRSRQRLNDLKVLLNDLGVECSVGGWPCSLACSVVAPCLRAEQLLVSVGAHGGRLRARVPAYPATPRMPELAAALAATDRTLVRQLLTQLRFWLVARRCEKSLQHLPASVCEHLPFLHGPDHPLNKLSPDRLYVTLHRHTDHILVVEMKEVAAGGTATTSCSSNTGSACSVALAFHLAGVRRCTPDECEDESSGTTSNTPATARAYLKLHSLVELDTFTLTHGPFTPLDTPGK |
Length | 599 |
Position | Tail |
Organism | Danaus plexippus plexippus |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea>
Nymphalidae> Danainae> Danaini> Danaina> Danaus> Danaus.
|
Aromaticity | 0.05 |
Grand average of hydropathy | 0.030 |
Instability index | 38.02 |
Isoelectric point | 9.15 |
Molecular weight | 65606.25 |
Publications | PubMed=22118469
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP14155
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
5| 372.90| 77| 78| 304| 380| 1
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142- 190 (26.94/ 7.98) ..................................RLPAV.....IR.E...RLVppP.....PLTP....aERRSTLRA...LAHVV..R..QRLttaslpSDVRNLK
212- 300 (81.75/37.88) GDAPNVP.WRLLDIAI...LIQDN.EtGEGKPLVHTSQLnwlrgVAQA...RLA..AaglsgALTAlrffcRSLSLELL...YTQTLRL.CRDRL.....aRHLQVDR
304- 380 (138.51/68.86) GQKLQVSYWRELGCELGYRLIVGA.E.GESLCVWHVPAL.....AGGE...RVA..A.....ALTP.....HAPSMERL...LAHTVHVRSRQRL......NDLKVLL
384- 460 (100.61/48.18) GVECSVGGW...PCSLACSVVAPClR.AEQLLV.SVGA......HGGRlraRVP..A.......YP.....ATPRMPELaaaLAATDRTLVRQLL......TQLRFWL
475- 503 (25.08/ 6.96) .............................SVC.EHLPFL.....HGPD...HPL..N.....KLSP..........DRL...YV.TLH....................
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 70.77| 21| 31| 51| 71| 3
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51- 71 (35.87/29.76) TDMERKIEIYKFSARTRQLFV
84- 104 (34.90/28.75) TKVDRSAHIMAFLDKQALLFV
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