<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14154

Description Mediator of RNA polymerase 2 transcription subunit 26
SequenceMSNNAHELSNRLLNALDSNYNVVDMQTVNEIISILEKFNITKELLETTRLGKHVNELRRKTSEPTLARRAKVLVKRWRDLVIPSTHSPAHTGSNRSSAERQVRRLGGTPLTSPALSRNLVSPAVPSPRPPSRPAWGGYESDSQDVILVDDDPPPPVTPSLAPLPPHKPATPPVKRALSPEPLYDEKKAKRDKKPKKRRGHGRAGSGTETTAEPQSQHNWVSRNGTGPERRRNGWKRDPPDPYAALVNRLPPAGAKKVKTTKELLEQIQSRGSSRPSRPASPRSPHSPASPASPDVMLIEPDVCPIKVESPLRNGGGDSAKTKMDPEPEEREEVPPLEEPRAWAECTCGEEEASADCPAAGRPALRPLHVRALHNVLLPGMNGTRAPLFPHRFAVRPPARDDDPTLFSSVVPLYNYSDYADDHCVKNMSRVPICERLPWTEFAPSPPPPSPPPSPPPLRPYPSPLREEVFPDLPEPDDDSADSSTTPNVIEATSEDEPREKPVIEPAMVGLAYMEPGERLKAPLLDDDDDYQLGEPRREVTVEKSFVSEPQEHRTVERTKEDIDGRTLYGLCEAALASVPYRYSQAAAAPVLTLPQLIERENEPPDHVAEDEAAKLLEGALETAAADPALDELGRPQRPLSFAEWHECARLGDLVALPYVVID
Length662
PositionUnknown
OrganismDanaus plexippus plexippus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Nymphalidae> Danainae> Danaini> Danaina> Danaus> Danaus.
Aromaticity0.04
Grand average of hydropathy-0.753
Instability index77.61
Isoelectric point5.58
Molecular weight72941.14
Publications
PubMed=22118469

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14154
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     456.28|      81|      83|     151|     233|       1
---------------------------------------------------------------------------
  151-  231 (145.68/42.59)	DP.......PPPVTPSLAPLPPHKPATPPVKRALS...PE......PLYDEKKAKRD....KKPKK....RRGHGRAGSGTETT..AEPQSQHNWV..S...RNGTGPERRR
  237-  321 (97.08/23.78)	DP.......PDPYAALVNRLPP....AGA.KKVKT...TK......ELLEQIQSRGS....SRPSRpaspRSPHSPASPASPDVmlIEPDVCPIKV..EsplRNGGGDSAKT
  324-  383 (71.36/16.68)	DP.......EPEEREEVPPL..EEP......RAWA....E......CTCGEEEASADcpaaGRPAL....RPLHVRA...L...........HNVLlpG...MNGT......
  385-  431 (46.37/ 8.50)	.................APLFPHRFAVRPPARDDD...PTlfssvvPLYN.................................Y..SDYADDHC.V..K...NMSRVP....
  437-  518 (95.79/24.67)	.PwtefapsPPPPSPPPSP.PPLRPYPSPLREEVFpdlPE......P..DDDSADSS....TTPNV........IEATSEDEPR..EKPVIEPAMV..G...LAYMEPGER.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.50|      36|      42|      56|      97|       2
---------------------------------------------------------------------------
   56-   97 (51.18/36.50)	ELRRKTSEPtLARRAkvLvkrWRDLVIPSTHSP......AHTGSNRSS
  101-  142 (60.32/27.95)	QVRRLGGTP.LTSPA..L...SRNLVSPAVPSPrppsrpAWGGYESDS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14154 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPGERLKAPLLDDDDDYQLGEPRREVTVEKSFVSEPQEHRTVERTKED
2) LPWTEFAPSPPPPSPPPSPPPLRPYPSPLREEVFPDLPEPDDDSADSSTTPNVIEATSEDEPREKPVIEPAMVGLA
3) PSTHSPAHTGSNRSSAERQVRRLGGTPLTSPALSRNLVSPAVPSPRPPSRPAWGGYESDSQDVILVDDDPPPPVTPSLAPLPPHKPATPPVKRALSPEPLYDEKKAKRDKKPKKRRGHGRAGSGTETTAEPQSQHNWVSRNGTGPERRRNGWKRDPPDPYAALVNRLPPAGAKKVKTTKELLEQIQSRGSSRPSRPASPRSPHSPASPASPDVMLIEPDVCPIKVESPLRNGGGDSAKTKMDPEPEEREEVPPLEEPRAWAE
514
436
83
561
511
344










Molecular Recognition Features






MoRF SequenceStartStop




1) AALVNRL
2) EPLYDEKKAKRDKKPKK
3) KTTKELL
4) KVLVKRWRDLVI
243
180
258
71
249
196
264
82