<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14153

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLVALTFACVSCRATNTGTCTSTGELRHGVLRLPRTLGAPRDRDGASHGGAETAPAAYCFQKETPVIGREGDQGSWESGLSYECRSLLFKALHNLIERCLLSRDFVRLGKWFVQPYDGDEEDVGKSSPWHLSFSFAFFLHGESTVCASVDVRQHPPVRTLTAKRLARLHTPAADRRGDNRVILAPFGLEGRVTGREWGENDPGTARLLDAWRQLYPLEQGCGAVEVECGGVRMPYPAPYALLTEMETCRDAAPPAAELAARALAALATPHPHQTAEVCYSETSGDANDDFLDPTRKTPCTCANVFHRGWARSVTPGLAGRSGCAATPSVTDLSPPCRASGCGAGCAGGGGACSPGSCGASPAAATSPAALTHAPHGQLTALTTHQQVSVPTTLHTPAPTPDPLAPPTPAPPSAPPHKLYAQGESPAGAGGPCAGQPPQEALRRPTLPPPEKRLDPLEDEHSLHMLYDYTTVHAWLEHPVKRFKSGGEAPRESSPAGDLYAGHDHTRLAATPAHVTLKIEKQDQEDVKEYKNLFTSDGLCPTLKDLDQIFDNSDDAASGDETLQVQTPPDSNKSSEEARGVSGRCVRAEELSKMFPTPPSMEAHAQPSPGFSPPDDHTHLHPHALRPHGSPPPDPVIEDWSYVFKPPTICKYVGSSKYAPLTALPSQLLPPVALPSTAVYRPRWQRGEERDDHAQTHRSESVSATSGSSTNTTTTTTSGVKRSSSNTERVTTSSSSGAAESRPSPRRLPGAPACPPPVSPRAPAPACPLLLNVLLADTVLNVFRDHNFDSCTLCVCNAGARTVGNIRGADAATYLPGGDWGGGPDDEPSRCSCGFSAIVNRRLAHRAGLFYEDEMEITGIAEEPGGGSGGGLADVAGVVVAACAAPAGGAASALARAARGAAAPPLADHLRLNLLEYSDGGAAAARALRAAAGGSGSSLPTPNIATGANSAVHRWPFIGARAPRSSRDVVRLMRRLRPLLQDAIQKRCCGARMWDGVSGPLTWRQFHRLAGRGNEDLCEPQPVPPLLVGHDRDWISLSPYALRHWERLSLEPYSYARDVAYVVLAADGEALSEPLKTFFREVSASYEACRLGRHQPITRIARDGIVRTAPAEGDRDANYEEWTGELPPGRLGEYMRSYAETLRSNLVPQLAALNVDRTLFERTAAWEEDEAGPPALVIYVVEPPAAHAHRPRALAALLRLASQVANHLHHHNPLVKIISLDGVCEWWGARGGWAAEARALAFSVFGGARRLMQHSPAGKSLTGFGTAATANLFINNKDEKNRAPYKLFSPAWVLSPPRALKEVAETWGTACGDQSSVLFLAYCLSHDQRWLLAAATDGRGELLDTAAINIHVPARSRRKRGGPARRLGLTKLMDFTLGVMSQSAQPWRLVVGRVGRIGHGELKGWSWLLSRPNLNRASNMLREMCGSCSLLYPTGAPCILSACLVSTEPDSCLRLMADRFTPDERFSQASIQSHLHTPRDVTATHILVFPTSATTQSNQMPFEPPNANGEENDMLLGLEMVDEDMGEDNMTDLLIGDMFMWPAGSPRASPRRHDDEASREGSPARNAHMNNTGAYTRDDDHHPEQVGTVLQQPLALGYLVSTAPLGAMPGWWWASCWHLRDACPAFLKNALHLQCAVTAHDDYTSLTQRRDHNAHPLDSTTTTDVLRYVLEGYNALSWLALDGSTHDRLSCLPLHVQVLMRLYHTAAALG
Length1709
PositionMiddle
OrganismDanaus plexippus plexippus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Nymphalidae> Danainae> Danaini> Danaina> Danaus> Danaus.
Aromaticity0.06
Grand average of hydropathy-0.356
Instability index53.77
Isoelectric point6.35
Molecular weight183886.84
Publications
PubMed=22118469

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14153
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     432.31|      88|     112|     248|     335|       1
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  155-  252 (98.46/30.29)	PPVRTLTAKRLARLH.TP..A................A.DRRGD.NRVILAPF.......GLEGRVTGRE...WGEN.DPGTARlldawrqlyplEQGCGAVEvE......CGGVRMP...ypapyalltemetCRD...AA
  253-  359 (147.79/48.78)	PPAAELAARALAALA.TP..HP.......HQTAEVCYS.ETSGDANDDFLDPT...RKTPCTCANVFHRG...WARSVTPGLAG...........RSGCAATP.S......VTDLSPPcrasgcgagcaggggaCSPgscGA
  360-  449 (108.41/34.02)	SPAA...ATSPAALThAP..HGqltalttHQQVSVPTTlHTPAPTPDPLAPPT...PAPPSAPP...HKL...YAQGESPAGAG............GPCAGQP.PqealrrPT.LPPP........................
  597-  662 (77.65/22.49)	PPSMEAHAQPSPGFS.PPddHT.......HLHPHALRP.HGS.PPPDPVIEDWsyvFKPPTICKYV...GsskYA....PLTA...........................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     285.66|      93|     112|    1201|    1311|       2
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 1201- 1311 (140.63/114.02)	SQV...ANHLHHHNPLVKIISLDGVCEWWGarggwaaearALAFSVFGGAR.RLMQHSPAGKslTGFGTAATANLFINNKDEKnraPYKL...............FSpaWVLSPPrALKEVAETWGTACG
 1314- 1425 (145.03/79.93)	SSVlflAYCLSHDQRWLLAAATDGRGELLD..........TAAINIHVPARsRRKRGGPARR..LGLTKLMDFTLGVMSQSAQ...PWRLvvgrvgrighgelkgWS..WLLSRP.NLNRASNMLREMCG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.70|      26|      37|     811|     847|       3
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  814-  847 (44.43/31.38)	L.............PGGDWGGGPDDepsrcscgFSAIVNRRLAHRAG
  849-  887 (39.27/10.55)	FyedemeitgiaeePGGGSGGGLAD........VAGVVVAACAAPAG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.54|      27|      36|     895|     928|       4
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  902-  928 (45.72/24.72)	APPLADHLRLNLLEYSDGGAAAARALR
  940-  966 (47.82/18.84)	TPNIATGANSAVHRWPFIGARAPRSSR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     291.77|      96|     855|     683|     791|       5
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  683-  791 (148.00/99.66)	WQRGEER......DDHAQthrSESVSATSGSSTNTTTTTtsgvKRSSSNTERVTT....SSSSGAAESRPSPRRLPG..APACpppVSPRapaPACPLLL.NVLLAD.........TVLNVFRDHN...FDSCT
 1540- 1660 (143.77/70.85)	WPAGSPRasprrhDDEAS...REGSPARNAHMNNTGAYT....RDDDHHPEQVGTvlqqPLALGYLVSTAPLGAMPGwwWASC...WHLR...DACPAFLkNALHLQcavtahddyTSLTQRRDHNahpLDSTT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.35|      29|      34|     455|     487|       6
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  455-  486 (51.10/41.58)	PLEDEHSLHmlyDYTTVHAWLEH...........PVKRFK....SGG
  494-  537 (40.25/19.48)	PAGDLYAGH...DHTRLAATPAHvtlkiekqdqeDVKEYKnlftSDG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.56|      17|     120|    1022|    1079|       7
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  991- 1008 (31.31/22.15)	RMWDGVSgPLTWRQFHRL
 1031- 1047 (34.26/57.16)	RDWISLS.PYALRHWERL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14153 with Med13 domain of Kingdom Metazoa
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