<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14151

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceMGSDDNWRTQNFRQNVVTKIEEVIQKSGMQVARNSSEMENHVFMKAKTREEYLNMVAKLILHVREMSQPKQNQGQNMQGPNQNQGGPANQAQTQQGQPQQGSSNQAGMATDPINALQNMTSQGSRNQMMNMGPGQMQQGVLGPNPGMGGMQTQMGQQGPIVSQGPQAQTATNLLQTLNQRPQLNMQLQNKLSGPIGMAPNQGQMGNNMVGGMGMGNMGSQLQNHLAAPGMQGQMMPNMSMSNTMQVPMSGASTIVGQMQCNQVVGGIGGQMTQNTMQGQMPNQMVGNMGNNQLVNINMLQMHRSQGKEVVMGAGYTQRAPPHNQFLRQSPSPSASSPNMPGPSPVSMGGGVLSGALSSPMGLGGLGACSGGSPNPSGNHHMTHHPPQQR
Length389
PositionTail
OrganismDanaus plexippus plexippus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Nymphalidae> Danainae> Danaini> Danaina> Danaus> Danaus.
Aromaticity0.02
Grand average of hydropathy-0.712
Instability index49.42
Isoelectric point10.01
Molecular weight41323.44
Publications
PubMed=22118469

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP14151
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     451.96|      82|      82|     126|     207|       1
---------------------------------------------------------------------------
   27-   99 (78.76/15.50)	.......SG.MQ..VARN..SSEMENH......vfmkaktrEEYL.NM.....VAKLILHV...RE..MSQPKQNQGQnmQGPNQNQGGPANQA....QTQQGQPQ...
  100-  185 (111.99/25.75)	...........Q..GSSN..QAGMATDpinalqnmtsqgsrNQMM.NMGP.GQMQQGVLGP...NP.GMGGMQTQMGQ..QGPIVSQGPQAQTATNLLQTLNQRPQLNM
  186-  248 (99.32/21.84)	QLQ.NKLSGPIG..MAPN..QGQMGNN..................................mvgGM.GMGNMGSQL....QNHLAAPGMQGQMMPNM..SMSNTMQVPM
  257-  334 (104.75/23.52)	QMQcNQVVGGIGgqMTQNtmQGQMPN................QMVgNMGN.NQ.....L.V...NI.NMLQMHRSQGK..E..VVMGAGYTQRAPPHNQFLRQSPSPSA
  335-  388 (57.14/ 8.84)	SSP.N.MPGPSP..VSMG..GGVLSGA.............lSSPM.GLGGlGACSGG..SP...NPsGNHHMTHHPPQ..Q............................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14151 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GIGGQMTQNTMQGQMPNQMVGNMGNNQLVNINMLQMHR
2) MGSDDNWRTQNFRQNVVTKIEEVIQKSGMQVARNSSEMENHVFMKAKT
3) NMVAKLILHVREMSQPKQNQGQNMQGPNQNQGGPANQAQTQQGQPQQGSSNQAGMATDPINALQNMTSQGSRNQMMNMGPGQMQQGVLGPNPGMGGMQTQMGQQGPIVSQGPQAQTATNLLQTLNQRPQLNMQLQNKLSGPIGMAPNQGQMGNNMVGGMGMGNMGSQLQNHLAAPGMQGQMMPNMSMSNTMQVPMSGAS
4) QGKEVVMGAGYTQRAPPHNQFLRQSPSPSASSPNMPGPSPVSMGGGVLSGAL
5) SPMGLGGLGACSGGSPNPSGNHHMTHHPPQQR
266
1
54
305
358
303
48
252
356
389










Molecular Recognition Features






MoRF SequenceStartStop




NANANA