<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14142

Description Cyclin dependent kinase 8
SequenceMDYEFKIKTQNERSKVEDLFDYEGCKVGRGTYGHVYKARRKDGSDTKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKANKKSVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIRKMPEHATLVKDFKRSNYQNCSLSKYMDRHKIKPDSKAFSLLQRLLLMDPNRRITSEQAMQDPYFSEDPLPTQDVFAGCPIPYPKREFLTDDDQEDKSDSKARQNQQQQQTNTQQNQVQANSHDHGANNAKRMRMSGPNQGNNATGNQQQEFHQQQQMMFGQQGGGQQQQNFQQRF
Length446
PositionKinase
OrganismDanaus plexippus plexippus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Nymphalidae> Danainae> Danaini> Danaina> Danaus> Danaus.
Aromaticity0.09
Grand average of hydropathy-0.772
Instability index42.72
Isoelectric point8.78
Molecular weight51854.25
Publications
PubMed=22118469

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats
>MDP14142
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.05|      31|      40|     215|     254|       1
---------------------------------------------------------------------------
  215-  254 (42.56/54.41)	IDiWaigcifaELLTSEPIFHCRQEDIKTSNpYHHDQLDR
  265-  295 (56.49/38.36)	KD.W.......EDIRKMPEHATLVKDFKRSN.YQNCSLSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.01|      14|      40|     372|     385|       2
---------------------------------------------------------------------------
  372-  385 (26.70/13.21)	ARQNQQ...QQQTNTQQ
  414-  427 (25.82/12.57)	ATGNQQ...QEFHQQQQ
  428-  444 (22.48/10.12)	MMFGQQgggQQQQNFQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.54|      31|      35|     135|     165|       3
---------------------------------------------------------------------------
  102-  127 (24.68/12.48)	.........HDLWhiiKFH..RAAKANKKSVMVPKGM
  135-  165 (57.28/37.86)	ILD.GIHYLHSNW...VLH..RDLKPANILVMGEGPE
  171-  203 (40.58/24.86)	IADmGFARLF.NA...PLKplADLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14142 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PNRRITSEQAMQDPYFSEDPLPTQDVFAGCPIPYPKREFLTDDDQEDKSDSKARQNQQQQQTNTQQNQVQANSHDHGANNAKRMRMSGPNQGNNATGNQQQEFHQQQQMMFGQQGGGQQQQNFQQRF
320
446










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRMRMS
2) QQNFQQRF
3) QQQEFHQQQQM
400
439
418
406
446
428