<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14124

Description Mediator of RNA polymerase 2 transcription subunit 12 protein
SequenceMRGVGVSAGCSCGSPAVRLANEPLLSLVLTCLRNQDDQKESLLSSIHAQLSHYLTHARDHDRSACGLSGDWHDEAAPDALQLRFSLAGGMFDAIRRSYQLTADWALLLTQLVAHQLIDAYNNSNLFTTLIDMLATLIHSTLAEGGDDNNRKHYQNLMKKLKKEIGDRHGPSIQAVRQLLPLSKNTIIEVIACEPLGCLMDQKGNKITGFDSDKKQGLRLTDKQRVSSWELVEGGRNPAPLSWAWFAATKIERKPLTYENAHSLVKPLSHYLEPLPLPPEDLDNNDNKQDNGSLDSSPTGSGKGRKMSCKMSNKISKKPKPTTPTNGGTPTGPGVPGAAGAQQPQFIQQQQWFPPPTQGYYNPPAGVNPRGVAPPSNTQSKQALSNMLRQRVPYQQMTQMQQQSGGYGGAPTPRPLPRQGMRQMQPGQMAQMQPNQMNPMAGMGSMGPMNQMGNVQMGPGQMSAAQMGGGQMGGNQMSGGQMGSGQMGGGQMGGMSGQMFGGQYGGMQQGYGYSQQMMPGSQQQMMNQGISQGGQMSQMSQQVNPMGQGVNSIGQSVGQINQGVGQSQQIPQGMGQMSQGMGQMGQAMGQIGQMGQGGGMGNMNSQAAPMGPQGGNSMGGFPGQQSFQQNMMGRQTSQEAYLAQQRQNARPQYMQQAPNVTMGGMGGPAPPYPRPMAPAQSAQYPQMQQRMRHQMLMQQGPLVQHLQQRQQYQQPY
Length715
PositionKinase
OrganismDanaus plexippus plexippus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Nymphalidae> Danainae> Danaini> Danaina> Danaus> Danaus.
Aromaticity0.05
Grand average of hydropathy-0.712
Instability index55.04
Isoelectric point9.46
Molecular weight77139.68
Publications
PubMed=22118469

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14124
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     196.66|      32|      32|     450|     481|       1
---------------------------------------------------------------------------
  402-  445 (36.98/ 6.43)	QSGGyggaptprplprqgmRQMQPGQM..AQMQP.NQ..M..NPMA.GmGSM
  450-  481 (70.24/19.69)	QMGN...............VQMGPGQMSAAQMGG.GQ..MGGNQMS.G.GQM
  502-  535 (44.64/ 9.48)	QYGG...............MQQGYG.YSQQMMPG.SQqqMMNQGISqG.GQM
  572-  599 (44.80/ 9.55)	GMGQ...............MSQGMGQMGQA.MGQiGQ..MG....Q.G.GGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     324.38|      52|      63|     600|     652|       2
---------------------------------------------------------------------------
  311-  359 (68.58/18.77)	SNkISKKPKPTTPtNGGTPTGpG....VP....GA..AG.....AQQPQF...IQQQQWFPPPTQG....Y
  360-  398 (55.89/13.71)	Y.......NP..P.AGVNPRG.V....AP....PS..NT.....QSKQALSNMLRQRVPYQQMTQ......
  536-  571 (45.04/ 9.52)	SQ.MSQQVNPMG..QGVNSIG.Q....SV....GQinQG.....VGQ...SQQIPQ...............
  600-  652 (93.60/30.72)	GN.MNSQAAPMGP.QGGNSMG.G....FP....GQ..QS.....FQQNMMGRQTSQEAYLAQQRQNaRPQY
  654-  711 (61.27/15.94)	......QQAPNVT.MGG..MG.GpappYPrpmaPA..QSaqypqMQQRMRHQMLMQQGPLVQHLQQ.RQQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.35|      10|      19|     250|     259|       3
---------------------------------------------------------------------------
  250-  259 (18.05/ 8.90)	IERKPLTYEN
  271-  280 (19.30/ 9.97)	LEPLPLPPED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.99|      24|      24|     106|     129|       4
---------------------------------------------------------------------------
   80-  103 (36.47/19.72)	LQLRFSLAGGMFDAIRRSYQLTAD
  106-  129 (38.05/20.84)	LLLTQLVAHQLIDAYNNSNLFTTL
  132-  149 (20.47/ 8.37)	MLAT.LIHSTLAEGGDDNN.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.31|      23|      24|      25|      47|       5
---------------------------------------------------------------------------
   25-   47 (38.63/26.52)	LSLVLTCLRNQDDQKESLLSSIH
   50-   72 (44.68/31.76)	LSHYLTHARDHDRSACGLSGDWH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.91|      16|     182|     295|     310|       6
---------------------------------------------------------------------------
  295-  310 (30.84/12.49)	SSPTGSGKGRKMSCKM
  483-  498 (32.07/13.31)	SGQMGGGQMGGMSGQM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14124 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQMMPGSQQQMMNQGISQGGQMSQMSQQVNPMGQGVNSIGQSVGQINQGVGQSQQIPQGMGQMSQGMGQMGQAMGQIGQMGQGGGMGNMNSQAAPMGPQGGNSMGGFPGQQSFQQNMMGRQTSQEAYLAQQRQNARPQYMQQAPNVTMGGMGGPAPPYPRPMAPAQSAQYPQMQQRMRHQMLMQQGPLVQHLQQRQQYQQPY
2) SHYLEPLPLPPEDLDNNDNKQDNGSLDSSPTGSGKGRKMSCKMSNKISKKPKPTTPTNGGTPTGPGVPGAAGAQQPQFIQQQQWFPPPTQGYYNPPAGVNPRGVAPPSNTQSKQALSNMLRQRVPYQQMTQMQQQSGGYGGAPTPRPLPRQGMRQMQPGQMAQMQPNQMNPMAGMGSMGPMNQMGNVQMGPGQMSAAQMGGGQMGGNQMSGGQMGSGQMGGGQMGGMSGQM
514
268
715
498










Molecular Recognition Features






MoRF SequenceStartStop




NANANA